Social Processes in Adolescent Anorexia Nervosa

项目摘要 饮食失调是严重的精神疾病，几乎没有有效的循证治疗方法， 对神经心理损伤的机械理解是疾病和康复的基础。我们有 先前发现的青少年和成年人处理社会行为的神经回路的差异 正在从神经性厌食症中恢复的女性然而，更好地理解社会之间的关系， 认知和临床症状需要了解这种疾病的个人早期在他们的过程中， 疾病和检查这些过程随着时间的推移恢复的进展。这一试点探索项目将 研究青少年妇女寻求治疗神经性厌食症的横向和纵向。 将收集年龄匹配的健康对照的比较数据。为了最大化数据，计算机管理 评估自我概念和社会决策的特征明确的神经成像任务的行为版本将 使用，使整个研究几乎完成。两个网站将招募参与者： UTSW和费城儿童医院（CHOP）的医疗中心饮食失调项目。的 进行虚拟评估和任务的能力允许纳入120名青少年女性（60名患有厌食症 在短时间范围内，在三个时间点（基线、3个月和6个月）， 一个R21这个探索性试点项目的目标1评估自我概念的认知差异，而目标2 研究社会交往中的行为差异。在每个目标中，获得的社会指标将是 评价组间差异及其与当前临床症状的关系。探索性 每个目标内的假设将考虑临床状态的变化是否与社会度量相关。在 通过这个试点项目的结束，我们将更好地了解自我概念的哪些组成部分， 神经性厌食症青少年的社会决策不同，以及这些结构如何与 精神病理学

PROJECT SUMMARY Eating disorders are serious mental illnesses with few effective evidence-based treatments and there is little mechanistic understanding of the neuropsychological impairments underlie both illness and recovery. We have previously identified differences in the neural circuits that process social behaviors in both adolescent and adult women recovering from anorexia nervosa. However, a better understanding of the relationships between social perceptions and clinical symptoms requires understanding this illness in individuals early in their course of the disease and examination of these processes over time as recovery progresses. This pilot exploratory project will examine adolescent women seeking treatment for anorexia nervosa both cross-sectionally and longitudinally. Comparison data from age-matched healthy controls will be collected. To maximize data, computer administered behavioral versions of well-characterized neuroimaging tasks assessing self-concept and social decisions will be utilized, allowing the entire study to be completed virtually. Two sites will recruit participants: Children’s Medical Center Eating Disorder Program at UTSW and the Children’s Hospital of Philadelphia (CHOP). The ability to conduct virtual assessments and tasks allows inclusion of 120 adolescent women (60 with anorexia nervosa and 60 healthy controls) at three time points (baseline, 3 months, and 6 months), in the short time frame of an R21. Aim 1 of this exploratory pilot project evaluates cognitive differences in self-concept while Aim 2 examines behavioral differences in social interactions. Within each aim, the social metrics obtained will be evaluated with regard to group differences and their relation to current clinical symptoms. An exploratory hypothesis within each aim will consider whether changes in clinical state are related to social metrics. At the conclusion of this pilot project, we will have a better understanding of which components of self-concept and social decisions differ in adolescents with anorexia nervosa and how these constructs are related to psychopathology.