Social Processes in Adolescent Anorexia Nervosa

项目总结 进食障碍是一种严重的精神疾病，几乎没有有效的循证治疗，也几乎没有 对神经心理损伤的机械性理解既是疾病的基础，也是康复的基础。我们有 此前已发现青少年和成年人处理社会行为的神经回路的差异 正在从神经性厌食症中恢复的女性。然而，更好地理解社会之间的关系 认知和临床症状需要在患者病程的早期了解这种疾病 随着康复进程的进展，随着时间的推移对这些过程进行疾病和检查。这一试探性项目将 对寻求治疗神经性厌食症的青春期妇女进行横断面和纵向检查。 将收集年龄匹配的健康对照组的比较数据。为了最大限度地利用数据，计算机管理 评估自我概念和社会决策的特征良好的神经成像任务的行为版本将 可供利用，使整个研究可以虚拟完成。两个网站将招募参与者：儿童 UTSW和费城儿童医院(CHOP)的医疗中心饮食障碍计划。这个 能够进行虚拟评估和任务，可以将120名青春期妇女(60名厌食症患者)包括在内 在短时间内的三个时间点(基线、3个月和6个月)， 一辆R21。该探索性先导项目的目标1评估自我概念的认知差异，而目标2 考察社交互动中的行为差异。在每个目标中，获得的社交指标将是 根据组内差异及其与当前临床症状的关系进行评估。探索性的 每个目标中的假设都将考虑临床状态的变化是否与社会指标有关。在 总结这个试点项目，我们将更好地了解自我概念的哪些组成部分 患有神经性厌食症的青少年的社会决定不同，以及这些结构如何与 精神变态学。

PROJECT SUMMARY Eating disorders are serious mental illnesses with few effective evidence-based treatments and there is little mechanistic understanding of the neuropsychological impairments underlie both illness and recovery. We have previously identified differences in the neural circuits that process social behaviors in both adolescent and adult women recovering from anorexia nervosa. However, a better understanding of the relationships between social perceptions and clinical symptoms requires understanding this illness in individuals early in their course of the disease and examination of these processes over time as recovery progresses. This pilot exploratory project will examine adolescent women seeking treatment for anorexia nervosa both cross-sectionally and longitudinally. Comparison data from age-matched healthy controls will be collected. To maximize data, computer administered behavioral versions of well-characterized neuroimaging tasks assessing self-concept and social decisions will be utilized, allowing the entire study to be completed virtually. Two sites will recruit participants: Children’s Medical Center Eating Disorder Program at UTSW and the Children’s Hospital of Philadelphia (CHOP). The ability to conduct virtual assessments and tasks allows inclusion of 120 adolescent women (60 with anorexia nervosa and 60 healthy controls) at three time points (baseline, 3 months, and 6 months), in the short time frame of an R21. Aim 1 of this exploratory pilot project evaluates cognitive differences in self-concept while Aim 2 examines behavioral differences in social interactions. Within each aim, the social metrics obtained will be evaluated with regard to group differences and their relation to current clinical symptoms. An exploratory hypothesis within each aim will consider whether changes in clinical state are related to social metrics. At the conclusion of this pilot project, we will have a better understanding of which components of self-concept and social decisions differ in adolescents with anorexia nervosa and how these constructs are related to psychopathology.