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Mechanisms of Sleep Disturbance in Children with Generalized Anxiety Disorder

广泛性焦虑症儿童睡眠障碍的机制

基本信息

批准号：
8411148
负责人：
Candice A Alfano
金额：
$ 16.62万
依托单位：
UNIVERSITY OF HOUSTON
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-02-01 至 2015-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8411148
关键词：
Address Adolescent Adult Aftercare Anxiety Anxiety Disorders Area Arousal Attention Behavior Child Childhood Chronic Clinical Research Cognitive Data Development Diagnostic Dimensions Disease Environmental Risk Factor Evaluation Exhibits Failure Family Fostering Generalized Anxiety Disorder Goals Home environment Hydrocortisone Impairment Injury Intervention Investigation Knowledge Laboratories Matched Group Medicine Mentored Patient-Oriented Research Career Development Award Mentorship Methods Occupational Parenting behavior Patients Polysomnography Prevalence Prospective Studies Psychopathology Recovery Regulation Relapse Reporting Research Research Ethics Research Methodology Research Personnel Research Training Risk Risk-Taking Salivary Schools Severities Short-Term Memory Sleep Sleep Disorders Sleep disturbances Sleeplessness Symptoms Training Translational Research actigraphy base career development childhood anxiety clinical practice clinically relevant emotion regulation experience functional disability programs prospective skills social success teacher

项目摘要

DESCRIPTION (provided by applicant): This is the second resubmission of an application for a Mentored Patient-Oriented Research Career Development Award (K23) to support the academic career development of the applicant. The candidate's long term goal is to develop a program of clinically-relevant, translational research focused on examining the influence and modifiability of sleep disturbance in the course and treatment of childhood anxiety disorders. Previously, the applicant has conducted research focused on the development of anxiety disorders in children and adolescents, including the prevalence of sleep disturbance. This application proposes training that is necessary for the next step in this research program, including advanced training in pediatric sleep medicine, laboratory-based training in the use and interpretation of polysomnography, assessment of neurohormonal dimensions of arousal in anxious children, and further training in research ethics and methodology. The mentorship of a select group of senior investigators will foster the candidate's development in a promising new area of research integrating two distinct areas of investigation: sleep medicine and developmental psychopathology. Prior research indicates that more than 90% of children with Generalized Anxiety Disorder (GAD) experience problems initiating and/or maintaining sleep; rates that are similar or higher than those found among adults with the disorder. Because persistent sleep disturbance during childhood is independently associated with multiple impairments in functioning including academic failure, decreased emotion regulation, decrements in attention and reasoning skills, injury risk, and risk-taking behavior, sleep problems among children with GAD may compound existing impairments, exacerbate anxiety symptoms, and result in lower recovery and higher relapse rates. The proposed study will use rigorous methods of assessment to address two primary aims: 1) to evaluate the persistence, features and daytime sequelae of sleep disturbance in children with GAD compared to a group of matched controls based on a one-week prospective, at-home assessment; and 2) to identify specific factors associated with the presence of sleep problems among children with GAD related to neurophysiologic and cognitive dimensions of arousal, and parenting and environmental factors. The training and research outlined in this proposal will equip the candidate with a unique set of necessary skills to advance knowledge in this important and under-researched area. Over the long-term, data will inform the development of empirically-based interventions for children with both sleep and anxiety disorders.

描述（由申请人提供）：这是第二次重新提交指导性患者导向研究职业发展奖（K23）申请，以支持申请人的学术职业发展。候选人的长期目标是开发一个临床相关的转化研究计划，重点是检查睡眠障碍在儿童焦虑症的过程和治疗中的影响和可改变性。此前，申请人曾针对儿童和青少年焦虑症的发展进行了研究，包括睡眠障碍的患病率。本申请提出了本研究计划下一步所需的培训，包括儿科睡眠医学的高级培训、多导睡眠图的使用和解释的实验室培训、焦虑儿童觉醒的神经激素维度的评估，以及研究伦理和研究方面的进一步培训。方法论。一组选定的高级研究人员的指导将促进候选人的一个有前途的新研究领域的发展整合了两个不同的研究领域：睡眠医学和发展精神病理学。先前的研究表明，超过 90% 的患有广泛性焦虑症 (GAD) 的儿童在启动和/或维持睡眠方面遇到问题；与患有该疾病的成年人中发现的比率相似或更高。由于儿童期持续的睡眠障碍与多种功能障碍独立相关，包括学业失败、情绪调节能力下降、注意力和推理能力下降、受伤风险和冒险行为，因此广泛性焦虑症儿童的睡眠问题可能会加剧现有的障碍，加剧焦虑症状，并导致恢复速度较低和复发率较高。拟议的研究将使用严格的评估方法来实现两个主要目标：1）根据为期一周的前瞻性在家评估，与一组匹配的对照组相比，评估广泛性焦虑症儿童睡眠障碍的持续性、特征和日间后遗症； 2）确定与广泛性焦虑症（GAD）儿童睡眠问题相关的具体因素，这些问题与唤醒的神经生理学和认知维度、养育和环境因素有关。本提案中概述的培训和研究将为候选人提供一套独特的必要技能，以增进这一重要且研究不足的领域的知识。从长远来看，数据将为针对患有睡眠障碍和焦虑症的儿童制定基于经验的干预措施提供信息。