Sleep, Emotional Processing, and Risk for Affective Disorders in Childhood

睡眠、情绪处理和童年情感障碍的风险

• 批准号: 8637575
• 负责人: Candice A Alfano
• 金额: $ 20.71万
• 依托单位: UNIVERSITY OF HOUSTON
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-04-01 至 2016-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8637575
• 关键词: 11 year old; 21 year old; Adolescence; Adolescent; Adult; Affect; Affective; Affective Symptoms; Age; Anxiety; Anxiety Disorders; Area; Arousal; Behavioral; Biological; Brain; Categories; Characteristics; Child; Childhood; Clinical Trials; Cognitive; Data; Depressive disorder; Development; Diagnostic; Disease; Early Intervention; Early identification; Electroencephalography; Emotional; Emotions; Epidemiologic Studies; Evaluation; Experimental Designs; Galvanic Skin Response; Goals; Heart Rate; Home environment; Intervention; Link; Mental Depression; Methods; Mood Disorders; National Institute of Mental Health; Neurobiology; Outcome; Pathway interactions; Patient Self-Report; Pattern; Physiological; Plant Roots; Polysomnography; Prevention; Process; Protocols documentation; Psychophysiology; REM Sleep; Recovery; Regulation; Research; Research Domain Criteria; Risk; Risk Factors; Role; Sleep; Sleep Architecture; Sleep Disorders; Slow-Wave Sleep; Strategic Planning; Symptoms; System; Translations; actigraphy; base; cost; depressive symptoms; design; effective intervention; high risk; insight; novel; psychosocial; public health relevance; response; sleep onset

DESCRIPTION (provided by applicant): Inadequate or disrupted sleep in childhood is highly predictive for the later development of anxiety disorders and depression. The combined societal cost of these disorders is estimated above $120 billion annually, underscoring a need for early identification and effective intervention methods. Experimental data in adults indicate a critical link between sleep disruption and affective disorders to exist in the maladaptive processing of emotion. In order to delineate specific risk mechanisms however, understanding of these relationships in childhood when sleep and emotion regulatory systems are developing is essential. An increased need for sleep and greater brain plasticity during the childhood years also suggest a 'window' of opportunity for intervention to exist. This study will use an experimental sleep restriction paradigm to identify cognitive, behavioral and physiologic mechanisms of affective risk among 50 pre-adolescent children, ages 7 to 11 years. We will include children with a range of (subclinical) anxious and depressive symptoms in order to determine whether certain affective profiles potentiate greater vulnerability in conjunction with sleep disruption than others. All children will undergo comprehensive psychosocial evaluation, in-home polysomnography and one week of actigraphy. A battery of novel tasks assessing discrete aspects of emotional processing (appraisal, reactivity and regulation) will be completed following a week of normal sleep and again after a 2-night sleep restriction protocol. In addition, because high-risk trajectories are characterized by the presence and interaction of multiple risk and protective factors, we will investigate the potential moderating influence of several theoretically-relevant cognitive and biological variables. In particular, children's cognitive response style, typical sleep onset latency, and preferred sleep pattern (i.e., chronotype) will be investigated as potential moderators of emotional outcomes. Finally, we will explore relationships among sleep architecture, EEG spectral power (during normal and recovery sleep) and emotional outcomes in order to identify potential neurobiological markers of affective response to sleep loss in childhood. The long term goal of this study which aligns with both NIMH's Strategic Plan and Research Domain Criteria (RDoC) is to advance existing prevention/early intervention protocols beyond non- specific targets toward more explicit mechanisms of risk.

描述（由申请人提供）：儿童时期的睡眠不足或破坏的睡眠对后来的焦虑症和抑郁症的发展具有很高的预测。这些疾病的综合社会成本每年估计高于1,200亿美元，强调了早期识别和有效干预方法的需求。成年人的实验数据表明，睡眠中断与情感障碍之间存在着关键的联系，使情绪适应不良。但是，为了描述特定的风险机制，当睡眠和情绪调节系统发展起来时，了解童年时期这些关系是必不可少的。在童年时代，对睡眠和大脑可塑性的需求增加也暗示了存在干预措施的“机会”。这项研究将使用实验性睡眠限制范式来识别50名年龄在7至11岁的青春期前儿童中情感风险的认知，行为和生理机制。我们将包括具有一系列（亚临床）焦虑和抑郁症状的儿童，以确定某些情感特征是否会比其他人相比会增强与睡眠破坏相结合的更大的脆弱性。所有儿童都将接受全面的社会心理评估，家庭多摄影术和一周的行为。评估情绪处理的离散方面（评估，反应性和调节）的一系列新任务将在正常睡眠后以及2夜睡眠限制协议后再次完成。此外， 由于高风险轨迹的特征是多种风险和保护因素的存在和相互作用，因此我们将研究几种理论上与理论上的认知和生物学变量的潜在调节作用。特别是，儿童的认知反应样式，典型的睡眠发作潜伏期和首选的睡眠方式（即Chronotype）将是 被调查为情感结果的潜在主持人。最后，我们将探索睡眠结构，脑电图光谱能力（在正常睡眠和恢复睡眠期间）和情绪结果之间的关系，以确定对儿童睡眠损失的情感反应的潜在神经生物学标志。这项研究的长期目标与NIMH的战略计划和研究领域标准（RDOC）保持一致的是，将现有的预防/早期干预方案推进了非特定目标，即具有更明确的风险机制。