Phase III COBRE in Stem & Progenitor Cell Biology and Regenerative Medicine

干细胞 III 期 COBRE

• 批准号: 8514209
• 负责人: DON Michael WOJCHOWSKI
• 金额: $ 109.11万
• 依托单位: MAINEHEALTH
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-01 至 2018-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8514209
• 关键词: Advisory Committees; Award; Cell Culture Techniques; Cell Energetics; Cell Separation; Cells; Cellular biology; Centers of Research Excellence; Collaborations; Core Facility; Development; Discipline; Doctor of Philosophy; Educational workshop; Faculty; Funding; Gene Expression; Genetic; Goals; Histopathology; Human Pathology; Investigation; Journals; Medical Research; Medical center; Mentors; Metabolic; Microscopy; Molecular Analysis; Mus; National Institute of General Medical Sciences; Nature; Phase; Phenotype; Physiology; Pilot Projects; Positioning Attribute; Publications; Publishing; Recruitment Activity; Regenerative Medicine; Research; Research Infrastructure; Research Institute; Research Personnel; Scientist; Secure; Seeds; Series; Services; Staging; Stem cells; Students; Training; Translational Research; United States National Institutes of Health; Wing; Work; bone imaging; member; molecular phenotype; mutant; programs; public health relevance; stem; success; symposium

DESCRIPTION (provided by applicant): This is a proposal for continued NIH/NIGMS support for our COBRE in Stem & Progenitor Cell Biology and Regenerative Medicine as we transition from successful Phase-ll status to a critical stage of Phase-Ill development. Prime goals are: i) Continue to advance thematic, biomedically relevant discoveries in stem and progenitor cell biology; ii) Sustain and extend strong internal and external advisory committees and supporting mechanisms to expertly mentor investigators, fellows, students and core staff; iii) Implement a Pilot Project Program to springboard highly promising discoveries towards national funding and impacting publications; iv) Work with our highly supportive Medical Center and Research Institute to recruit additional strong COBRE Center investigators; v) Continue to sharpen the expertise, efficiency, utility and selfsustaining nature of our Center's Research Core Facilities. During Phase-ll, we have further advanced impacting discoveries in our discipline, published studies in excellent journals, mentored and advanced Center investigations, recruited strong new investigators, and demonstrated clear success in securing independent national funding. Gains in infrastructure and Institutional support also are significant. These include the construction of a new research wing, the ongoing recruitment of additional scientists, the advancement of existing core facilities, and the development of a highly needed Physiology Core. In Phase-Ill, the PI will be assisted administratively by a co-lnvestigator (L. Oxburgh, PhD, DVM COBRE member since 2005) and Program Coordinator (E. Jachimowicz). Our administrative core will implement a Pilot Project Program for outstanding seed investigations, and to advance new translational research opportunities; a core workshop and summer symposium in Stem & Progenitor Cell Biology; an invited seminar series; and the recruitment of a magnet clinician scientist. Core facilities also will be enhanced. The Molecular Phenotyping Core focuses on quantitative molecular analysis of gene expression and cellular microscopy. The Histopathology Core provides expert histological support plus new collaborations involving human pathology studies, and mouse genetic mutants. Our Progenitor Cell Analysis Core provides flow cytometric analyses, cell sorting, clonal cell analyses and stem/progenitor cell culture services. Our new Physiology Core will provide state-of-the-art metabolic phenotyping, skeletal imaging and cell energetic analyses. Specific plans towards Core and Center self-sufficiency post- Phase-Ill also are defined.

描述（由申请人提供）：这是一个持续的NIH/NIGMS支持我们的COBRE在干细胞和祖细胞生物学和再生医学的建议，因为我们从成功的II期状态过渡到III期发展的关键阶段。主要目标是：i）继续推进干细胞和祖细胞生物学领域的主题性、生物医学相关发现; ii）维持和扩大强有力的内部和外部咨询委员会和支持机制，以专业指导研究人员、研究员、学生和核心工作人员; iii）实施试点项目计划，将极具前景的发现推向国家资助和影响出版物; iv）与我们高度支持的医疗中心和研究机构合作，招募更多强大的COBRE中心研究人员; v）继续提高我们中心研究核心设施的专业知识，效率，效用和自我维持性质。在第二阶段，我们在我们的学科中进一步推进了有影响力的发现，在优秀期刊上发表了研究，指导和推进了中心调查，招募了强大的新研究人员，并在获得独立的国家资金方面取得了明显的成功。在基础设施和机构支助方面也取得了重大进展。这些措施包括建设一个新的研究翼，正在招募更多的科学家，现有的核心设施的进步，以及一个急需的生理学核心的发展。在III期，PI将由一名共同研究者（L. Oxburgh博士， 自2005年以来，DVM COBRE成员）和项目协调员（E。Jachimowicz）。我们的行政核心将实施一个试点项目计划，用于优秀的种子调查，并推动新的转化研究机会;干细胞和祖细胞生物学的核心研讨会和夏季研讨会;受邀研讨会系列;和招聘磁铁临床医生科学家。核心设施也将得到加强。分子表型核心重点关注基因表达的定量分子分析和细胞显微镜检查。组织学核心提供专家组织学支持，以及涉及人类病理学研究和小鼠遗传突变体的新合作。我们的祖细胞分析中心提供流式细胞仪分析、细胞分选、克隆细胞分析和干/祖细胞培养服务。我们新的生理学核心将提供最先进的代谢表型分析、骨骼成像和细胞能量分析。还确定了实现第三阶段后核心和中心自给自足的具体计划。