Functional connectivity in primary visual cortex (request for administrative supp

初级视觉皮层的功能连接（请求行政支持）

• 批准号: 8532443
• 负责人: Jose Manuel Alonso
• 金额: $ 12.66万
• 依托单位: STATE COLLEGE OF OPTOMETRY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-01 至 2017-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8532443
• 关键词: Algorithms; Amblyopia; Animals; Architecture; Brain; Cartoons; Cerebral cortex; Computer Simulation; Contralateral; Data; Databases; Development; Dimensions; Electrodes; Eye; Felis catus; Future; Goals; Grant; Human; Image; Imagery; Implant; Interphase; Knowledge; Light; Location; Macular degeneration; Maps; Measurement; Measures; Medical Imaging; Methods; Modeling; Neurons; Noise; Ocular Dominance; Output; Perception; Periodicity; Phase; Play; Positioning Attribute; Problem Solving; Property; Prosthesis; Reporting; Research; Research Project Grants; Resolution; Retinal; Role; Sensory; Signal Transduction; Simulate; Site; Solid; Stimulus; Structure; Testing; Thalamic structure; Therapeutic; Time; Tissues; Vision Disorders; Visual; Visual Cortex; Work; area striata; base; image processing; innovation; novel strategies; optical imaging; orientation columns; orientation selectivity; phase change; receptive field; repaired; response; retinotopic; sample fixation; success; visual map

DESCRIPTION (provided by applicant): The human brain needs to have access to an accurate map of visual space to interpret the images that we see. The most accurate and complete visual map is located in primary visual cortex, where all the basic stimulus properties are thought to be systematically represented, including spatial location, orientation and phase. For example, a vertical dark bar in the middle of this page can be represented in primary visual cortex by its position (point of fixation), orientation (vertical) and phase (dark flanked by light. While previous studies have made important advances in our understanding of how spatial location and orientation are mapped across the primary visual cortex, we still do not know how spatial phase is represented in this map. This is a fundamental gap in knowledge given the importance that phase has in image processing algorithms, which are regularly applied to satellite imagery, medical imaging, videophone and character recognition. Current experimental data suggest that spatial phase is randomly distributed throughout the cortex; however, computational models keep insisting that phase should be clustered in specific regions of the cortical map. Our recent results demonstrate, for the first time, the existence of pronounced clusters for spatial phase that are closely related to the mapping of stimulus orientation in cortex. In addition, we show that dark-dominated phases are better represented than light-dominated ones. The main goal of this research project is to study the organization of these newly discovered cortical maps for spatial phase with a novel approach that takes advantage of recent advances in multielectrode recording and has considerably better spatio-temporal resolution than other methods used in the past. With our multielectrode approach, we will reveal the inter- related organization of visual cortical maps for spatial position, orientation and phase the topography of dark- dominance in these maps and the rules that govern the representation of multiple stimulus dimensions within each 100 x 100 microns of cortex. We will use these measurements to build a detailed database of the multi- dimensional mapping of stimulus features across the visual cortical map and to test current computational models of functional cortical architecture and cortical development.

描述（由申请人提供）：人脑需要访问准确的视觉空间图，以解释我们看到的图像。最准确，最完整的视觉图位于主要的视觉皮层中，其中所有基本的刺激特性都被认为是系统地表示的，包括空间位置，方向和相位。例如，本页中间的垂直暗条可以通过其位置（固定点），定向（垂直）和相位（黑暗侧翼光。图像处理算法是定期应用于卫星图像，医学成像，视频识别和特征识别的，这表明空间阶段是随机分布在整个皮层中，但是，计算模型不断地确保阶段在我们最近的封闭范围内群群群。刺激的方向，我们表明，黑暗主导的阶段比光主导的阶段更好地代表了该研究项目的主要目标。与空间位置，方向和相位的视觉皮层图相关的组织，这些地图中的黑暗占优势的地形以及在每个100 x 100微米中的多个刺激尺寸表示的规则中，我们将使用这些测量值来构建跨度模型的详细仪器构图，以构建视觉效果的详细绘制。 发展。