The Influence of Aerobic Exercise on Cognitive Functioning in Schizophrenia

有氧运动对精神分裂症认知功能的影响

• 批准号: 8228389
• 负责人: DAVID KIMHY
• 金额: $ 24万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-03-08 至 2014-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8228389
• 关键词: Academic Medical Centers; Address; Adolescent; Adult; Aerobic; Aerobic Exercise; Antipsychotic Agents; Attention; Behavior Therapy; Clinical Trials; Cognition; Cognitive; Cognitive deficits; Cognitive remediation; Control Groups; Counseling; Data; Development; Elderly; Female; Generations; Hippocampus (Brain); Hour; Human; Impaired cognition; Impairment; Incidence; Individual; Intervention; Investments; Lead; Life Style; Link; Literature; Medical center; Memory; Meta-Analysis; Neurocognitive; New York City; Outpatients; Participant; Patients; Physiological; Population; Public Health; Publishing; Randomized; Randomized Clinical Trials; Reporting; Research; Schizophrenia; Severities; Short-Term Memory; Signal Transduction; Symptoms; Time; Training; Training Programs; Verbal Learning; animal data; base; behavior measurement; blind; cognitive function; daily functioning; disability; executive function; fitness; follow-up; functional disability; functional outcomes; improved; improved functioning; interest; male; memory process; novel; processing speed; programs; sedentary; social cognition; treatment as usual; visual learning; young adult

DESCRIPTION (provided by applicant): Schizophrenia has a population incidence of 1%, but it is the 9th leading cause of disability worldwide. Individuals with schizophrenia display a broad range of cognitive deficits that have been identified as major determinants of poor daily functioning and disability, thus representing a serious public health concern. Current pharmacological and cognitive remediation treatments offer limited to modest efficacy in improving these deficits. However, data from animal and human research strongly support the positive influence of Aerobic Exercise (AE) on cognitive functioning. As individuals with schizophrenia typically display cognitive deficits along with a highly sedentary lifestyle, and preliminary evidence suggest that AE training is both feasible and effective in increasing aerobic fitness in this population, it is reasonable to hypothesize that AE may also improve cognitive functioning. However, this association has hardly been investigated in schizophrenia. To elucidate this putative link, we propose to evaluate the influence of AE on cognitive functioning in schizophrenia using a single-blind, randomized clinical trial. Outpatient individuals with schizophrenia (n=48) receiving treatment at a large academic medical center in New York City will be randomly assigned to Aerobic Exercise (AE) training or Treatment As Usual (TAU). Participants in the AE training will undergo a 12-week, 3 times per week, 1-hour AE sessions at the medical center. All patients will receive appropriate pharmacological and counseling treatment. Assessments of neurocognitive and daily functioning abilities, along with symptom severity, and physiological and behavioral measures of aerobic fitness will be completed before and after the 12-week program by raters blind to treatment status. This study will allow determining the putative positive influence of AE on cognitive and daily functioning in individuals with schizophrenia. PUBLIC HEALTH RELEVANCE: Individuals with schizophrenia suffer from cognitive impairments that have been identified as major determinants of poor functioning and disability. Aerobic Exercises (AE) have been shown to improve cognition in healthy individuals, but their influence in schizophrenia have not been studied. Elucidating the link between AE and cognition in schizophrenia may lead to development of novel behavioral treatments targeting cognitive deficits in schizophrenia.

描述（由申请人提供）：精神分裂症的人口发病率为 1%，但它是全球第九大致残原因。精神分裂症患者表现出广泛的认知缺陷，这些缺陷已被确定为日常功能不佳和残疾的主要决定因素，从而构成了严重的公共卫生问题。目前的药物和认知治疗在改善这些缺陷方面的功效有限。然而，来自动物和人类研究的数据强烈支持有氧运动 (AE) 对认知功能的积极影响。由于精神分裂症患者通常会表现出认知缺陷以及高度久坐的生活方式，并且初步证据表明 AE 训练对于增加该人群的有氧适能既可行又有效，因此可以合理地假设 AE 也可以改善认知功能。然而，这种关联在精神分裂症中几乎没有被研究过。为了阐明这种假定的联系，我们建议使用单盲、随机临床试验来评估 AE 对精神分裂症认知功能的影响。在纽约市一家大型学术医疗中心接受治疗的精神分裂症门诊患者 (n=48) 将被随机分配接受有氧运动 (AE) 训练或照常治疗 (TAU)。 AE 培训的参与者将在医疗中心接受为期 12 周、每周 3 次、每次 1 小时的 AE 课程。所有患者都将接受适当的药物和咨询治疗。对神经认知和日常功能能力、症状严重程度以及有氧健身的生理和行为测量的评估将由不了解治疗状态的评估者在为期 12 周的计划之前和之后完成。这项研究将确定 AE 对精神分裂症患者认知和日常功能的假定积极影响。 公共卫生相关性：精神分裂症患者患有认知障碍，这已被确定为功能不良和残疾的主要决定因素。有氧运动（AE）已被证明可以改善健康个体的认知能力，但其对精神分裂症的影响尚未得到研究。阐明 AE 与精神分裂症认知之间的联系可能会导致针对精神分裂症认知缺陷的新型行为治疗的发展。