Neurocognition After Perturbed Sleep (NAPS)

睡眠障碍后的神经认知 (NAPS)

• 批准号: 10196093
• 负责人: DAVID KIMHY
• 金额: $ 21.02万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-06-09 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10196093
• 关键词: Address; Affective; Animal Experimentation; Architecture; Biological Markers; Blood specimen; Cellular Phone; Characteristics; Chronic; Clinical; Clinical Research; Clinical Trials; Cognitive; Data; Development; Diagnosis; Electroencephalography; Electrophysiology (science); Evaluation; Future; Goals; Home; Hour; Impairment; Individual; Infrastructure; Intervention; Intervention Studies; Link; Literature; Memory; Methods; Modeling; Moods; Nature; Neurocognition; Neurocognitive; Neurocognitive Deficit; Participant; Patient Self-Report; Patients; Persons; Pharmaceutical Preparations; Play; Polysomnography; Population; Prevalence; Psychoses; Public Health; Reporting; Role; Sampling; Schedule; Schizophrenia; Sleep; Sleep Architecture; Sleep Disorders; Sleep disturbances; Sleeplessness; Slow-Wave Sleep; Social Functioning; Symptoms; Task Performances; actigraphy; clinical effect; clinically significant; cognitive function; daily functioning; density; design; diaries; disability; emotion regulation; experience; experimental study; indexing; memory consolidation; mood symptom; neurocognitive test; pre-clinical research; psychotic symptoms; side effect; sleep spindle; therapy development

Project Summary: The goal of this study is to investigate the impact of sleep on neurocognitive and daily functioning in people with schizophrenia (SZ). Individuals with SZ display a broad range of neurocognitive impairments that have been identified as major determinants of poor functioning and disability, thus representing an important public health concern and a focal target for interventions. Extensive animal, preclinical and clinical research literatures converge in highlighting the critical role insomnia and sleep disturbances play in degrading neurocognitive functioning. Such sleep disturbances, which have been linked to reduced slow wave sleep oscillations and thalamo- cortical sleep spindles, result in clinical presentations that are in line with the neurocognitive difficulties commonly observed in people with SZ. Consistent with these findings, insomnia and sleep disturbances are highly prevalent in people with SZ. However, despite their chronic and ubiquitous nature, there are scant data on the impact sleep disturbances on neurocognition in SZ and there are no data quantifying their influence on daily functioning. Thus, sleep disturbances remain poorly understood and modeled in SZ, their impact is rarely considered in clinical trials, and they remain largely unaddressed by clinicians. To address this gap in the literature, the primary aim of this study is to characterize sleep in individuals with SZ and quantify its impact on neurocognition and daily functioning. Employing an experimental, within-person, repeated assessment design, we will characterize sleep architecture, duration, and quality along with cognitive, electrophysiological, biomarkers and daily functioning sequalae in 40 individuals with SZ. Participants will first complete a week-long, in-home characterization of sleep duration and quality using actigraphy and a sleep diary. Next, they will complete two overnight polysomnography examinations employing two sleep schedules: 1) undisturbed sleep; and 2) restricted sleep (4 hours). As part of these assessments, participants will provide blood samples for biomarkers analyses and complete EEG-indexed memory tasks pre- and post-sleep, along with a post-sleep battery of neurocognitive functioning. Finally, participants will complete a 36- hour ambulatory assessment using actigraphy and smartphones employing Experience Sampling Method (ESM) to explore the impact of sleep on “real-world” daily functioning including symptoms, emotion regulation, and mood. PublicHealth Relevance Statement:This study will provide experimental characterization of the links between sleep neurocognition and functioning in individuals with SZ, informing the development of treatments of neurocognitive deficits in SZ.

项目 总结： 本研究的目的是调查睡眠对神经认知和日常功能的影响 精神分裂症患者（SZ）。SZ患者表现出广泛的神经认知功能障碍 已被确定为功能不良和残疾的主要决定因素的损伤， 因此，这是一个重要的公共卫生问题，也是干预的重点目标。 广泛的动物、临床前和临床研究文献集中强调了 失眠和睡眠障碍在降低神经认知功能中的作用。这样的睡眠 干扰，这已与减少慢波睡眠振荡和丘脑- 皮层睡眠纺锤波，导致临床表现符合神经认知 在SZ患者中常见的困难。与这些发现一致，失眠和 睡眠障碍在SZ患者中非常普遍。然而，尽管他们的慢性和 普遍存在的性质，有睡眠障碍的影响，在深圳神经认知的数据很少 也没有数据量化它们对日常功能的影响。因此，睡眠障碍 在SZ中仍然知之甚少，模型化程度也很低，临床试验中很少考虑它们的影响， 并且它们在很大程度上仍未被临床医生解决。为了解决文献中的这一空白， 本研究的主要目的是描述SZ患者的睡眠特征，并量化其对 神经认知和日常功能。使用一个实验性的，在人，重复 评估设计，我们将表征睡眠结构，持续时间和质量沿着 认知，电生理学，生物标志物和日常功能后遗症40个人， SZ.参与者将首先完成为期一周的，在家里表征睡眠时间， 使用体动记录仪和睡眠日记来提高睡眠质量。接下来，他们将在一夜之间完成两个 采用两种睡眠时间表的多导睡眠图检查：1）不受干扰的睡眠;以及2） 限制睡眠（4小时）。作为这些评估的一部分，参与者将提供血液样本 用于生物标志物分析和完成睡眠前和睡眠后的EEG索引记忆任务，沿着 睡眠后的神经认知功能最后，参与者将完成一个36- 使用体动记录仪和智能手机进行小时动态评估，采用经验采样 方法（ESM）探索睡眠对“现实世界”日常功能的影响，包括 症状、情绪调节和情绪。 公共卫生相关性声明：本研究将提供 睡眠神经认知与SZ患者功能之间的联系，为研究提供了信息。 SZ神经认知缺陷治疗的发展。