Neurocognition After Perturbed Sleep (NAPS)

项目 摘要： 这项研究的目的是调查睡眠对神经认知和日常功能的影响 在精神分裂症(SZ)患者中。SZ患者表现出广泛的神经认知能力 已被确定为功能不良和残疾的主要决定因素的损害， 因此，这是一个重要的公共卫生问题，也是干预措施的重点目标。 广泛的动物、临床前和临床研究文献汇聚在一起，强调了关键 失眠和睡眠障碍在降低神经认知功能方面发挥着作用。这样的睡眠 干扰，这与慢波睡眠振荡和丘脑- 皮质睡眠纺锤体，导致符合神经认知的临床表现 在SZ患者中通常观察到困难。与这些发现一致的是，失眠和 睡眠障碍在SZ患者中非常普遍。然而，尽管他们的长期和 无处不在的自然界中，关于睡眠障碍对SZ神经认知的影响的数据很少 也没有数据可以量化它们对日常功能的影响。因此，睡眠障碍 在深圳仍然缺乏了解和建模，它们的影响很少在临床试验中考虑， 而且这些问题在很大程度上仍未得到临床医生的解决。为了解决文献中的这一差距， 这项研究的主要目的是描述患有SZ的人的睡眠特征，并量化其对 神经认知和日常功能。使用实验性的、面对面的、重复的 评估设计，我们将描述睡眠结构、持续时间和质量，以及 40例精神分裂症患者认知、电生理、生物标志物及日常功能后遗症 SZ.参与者将首先完成为期一周的家庭睡眠持续时间和 使用动作记录仪和睡眠日记来提高质量。接下来，他们将在一夜之间完成两个 多导睡眠图检查采用两种睡眠时间表：1)不受干扰的睡眠；和2) 睡眠受限(4小时)。作为评估的一部分，参与者将提供血液样本 用于生物标记物分析和完成睡眠前和睡眠后的脑电索引记忆任务 睡眠后的神经认知功能。最后，参与者将完成36- 使用动作记录仪和采用体验采样的智能手机进行小时动态评估 方法(ESM)探索睡眠对现实世界日常功能的影响，包括 症状、情绪调节和情绪。 公共健康相关声明：这项研究将提供对 睡眠神经认知和SZ患者功能之间的联系，告知 深圳地区神经认知障碍的治疗进展。

Project Summary: The goal of this study is to investigate the impact of sleep on neurocognitive and daily functioning in people with schizophrenia (SZ). Individuals with SZ display a broad range of neurocognitive impairments that have been identified as major determinants of poor functioning and disability, thus representing an important public health concern and a focal target for interventions. Extensive animal, preclinical and clinical research literatures converge in highlighting the critical role insomnia and sleep disturbances play in degrading neurocognitive functioning. Such sleep disturbances, which have been linked to reduced slow wave sleep oscillations and thalamo- cortical sleep spindles, result in clinical presentations that are in line with the neurocognitive difficulties commonly observed in people with SZ. Consistent with these findings, insomnia and sleep disturbances are highly prevalent in people with SZ. However, despite their chronic and ubiquitous nature, there are scant data on the impact sleep disturbances on neurocognition in SZ and there are no data quantifying their influence on daily functioning. Thus, sleep disturbances remain poorly understood and modeled in SZ, their impact is rarely considered in clinical trials, and they remain largely unaddressed by clinicians. To address this gap in the literature, the primary aim of this study is to characterize sleep in individuals with SZ and quantify its impact on neurocognition and daily functioning. Employing an experimental, within-person, repeated assessment design, we will characterize sleep architecture, duration, and quality along with cognitive, electrophysiological, biomarkers and daily functioning sequalae in 40 individuals with SZ. Participants will first complete a week-long, in-home characterization of sleep duration and quality using actigraphy and a sleep diary. Next, they will complete two overnight polysomnography examinations employing two sleep schedules: 1) undisturbed sleep; and 2) restricted sleep (4 hours). As part of these assessments, participants will provide blood samples for biomarkers analyses and complete EEG-indexed memory tasks pre- and post-sleep, along with a post-sleep battery of neurocognitive functioning. Finally, participants will complete a 36- hour ambulatory assessment using actigraphy and smartphones employing Experience Sampling Method (ESM) to explore the impact of sleep on “real-world” daily functioning including symptoms, emotion regulation, and mood. PublicHealth Relevance Statement:This study will provide experimental characterization of the links between sleep neurocognition and functioning in individuals with SZ, informing the development of treatments of neurocognitive deficits in SZ.