Improving Cognition via Exercise in Schizophrenia

通过运动改善精神分裂症患者的认知

• 批准号: 10009462
• 负责人: DAVID KIMHY
• 金额: $ 143.06万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-15 至 2024-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10009462
• 关键词: Address; Aerobic Exercise; Age; Animals; Attention; Biological; Biological Markers; Brain-Derived Neurotrophic Factor; Characteristics; Clinical Trials Design; Cognition; Cognitive; Cognitive deficits; Cognitive remediation; Communities; Data; Effectiveness; Equipment; Exercise; Funding; Geography; Goals; Hour; Human; Impaired cognition; Individual; Infrastructure; Interleukin-6; Intervention; Link; Literature; Measures; Mediating; Mental disorders; Outcome; Participant; Pharmacology; Physical activity; Pilot Projects; Play; Public Health; Randomized; Randomized Clinical Trials; Regulation; Reporting; Reproducibility; Research; Sampling; Schizophrenia; Serum; Single-Blind Study; Site; Stretching; TNF gene; Training; Up-Regulation; Video Games; base; cognitive benefits; cognitive change; cognitive function; confirmatory clinical trial; daily functioning; design; disability; effectiveness implementation study; efficacy study; exercise training; functional disability; functional outcomes; improved; improved functioning; inflammatory marker; neurotrophic factor; neurotrophin 4; novel; response; sex; treatment program

Project Summary DESCRIPTION (provided by applicant): The goal of the proposed study is to examine the impact of aerobic exercise (AE) training on cognitive functioning in people with schizophrenia (SZ). People with SZ display a broad range of cognitive impairments that have been identified as major determinants of poor functional outcome and disability, thus representing an important public health concern and a target for interventions. At present, available treatments offer only minimal to limited benefits to ameliorate these deficits. Extensive animal and human research literatures converge in supporting the positive influence of AE training on cognitive functioning. Preliminary data indicate that AE training is effective in improving cognitive functioning in people with SZ. However, previous studies employed small samples, making it difficult to ascertain the potential impact of relevant biological variables. Additional limitations include focus on a single or limited range of cognitive domains and insufficient information on daily functioning or putative biomarkers underlying cognitive change. Finally, previous studies tended to view AE as a uniform intervention, with limited attention given to intervention characteristics, an issue critical to reproducibility. Thus, we lack fully powered studies to provide information to inform decisions regarding the effectiveness of AE training to ameliorate cognitive deficits in SZ. Altogether, these limitations hinder our ability to make informed decisions regarding the efficacy of AE to address cognitive deficits in people with SZ. To tackle this very specific need, the proposed research focuses on three major aims - AIM 1: confirm the efficacy of AE training to improve cognition in people with SZ; AIM 2: examine the impact of AE on daily functioning; and AIM 3: examine brain-derived neurotrophic factor (BDNF) as an AE-related biomarker of cognitive-change. Employing a single-blind, randomized clinical trial design, we will randomly assign 200 individuals with SZ from 4 U.S. sites to one of two 12-week, 3x-week, 1-hour treatment programs: 1) AE or 2) A stretching and toning (ST) control condition. All participants will undergo assessments of aerobic fitness, cognition, daily functioning, BDNF, and other putative biomarkers of cognitive change before the training and after 6- and 12-weeks of interventions.

项目摘要 描述（由申请人提供）：拟议研究的目标是检查有氧运动的影响 运动（AE）训练对精神分裂症（SZ）患者认知功能的影响SZ患者表现出 广泛的认知障碍已被确定为功能障碍的主要决定因素， 因此，这是一个重要的公共卫生问题，也是干预措施的目标。在 目前，可用的治疗仅提供最小到有限的改善这些缺陷的益处。广泛 动物和人类研究文献都支持AE训练对认知能力的积极影响， 功能初步数据表明，AE训练对改善人们的认知功能是有效的。 关于SZ然而，以前的研究采用小样本，难以确定潜在的 相关生物变量的影响。其他限制包括关注单个或有限范围的 认知领域和关于日常功能或认知基础的假定生物标志物的信息不足 变化最后，以前的研究倾向于将AE视为统一的干预措施，对以下方面的关注有限： 干预的特点，一个问题的关键再现性。因此，我们缺乏充分的研究来提供 信息，以告知有关AE培训改善SZ认知缺陷的有效性的决策。 总之，这些局限性阻碍了我们就AE的疗效做出明智决定的能力， 解决SZ患者的认知缺陷。为了解决这一非常具体的需求，拟议的研究重点 三个主要目标-目的1：确认AE训练对改善SZ患者认知的疗效;目的2： 检查AE对日常功能的影响;和AIM 3：检查脑源性神经营养因子（BDNF） 作为认知变化的AE相关生物标志物。采用单盲、随机临床试验设计，我们 将随机分配来自4个美国研究中心的200名SZ患者至两个12周、3周、1小时的研究中心之一 治疗程序：1）AE或2）拉伸和调色（ST）控制条件。所有参与者将接受 评估有氧健身，认知，日常功能，BDNF和其他公认的认知生物标志物 培训前和干预6周和12周后的变化。