Overall Center Research Strategy p153-170

南方大学烟草监管科学中心（TCORS）的申请 加州（南加州大学）解决了不同人群之间烟草使用的交叉问题，提出了一项 方法开发和研究的议程，以确保食品和药物管理局的活动 美国食品和药物管理局（FDA）的烟草产品中心（CTP）接触到许多有尼古丁成瘾风险的群体 以及烟草使用的不良后果。拟议的南加州大学TCORS直接响应RFA-DA-13- 003与一个经验丰富的多学科调查小组谁已经在烟草合作 在被认为易受烟草使用和成瘾影响的不同人群中开展的研究。这些人口 与其他美国人口相比，烟草使用率高和/或不断扩大， 特别容易受到烟草业营销、社交媒体 传播和文化网络，提出了烟草使用规范。有三个总体研究 本TCORS的目的：1）评估营销、社会影响、社交媒体和网络对烟草的影响 使用和产品选择，强调弱势群体，最终目的是确定如何 扭转或抵消这些影响; 2）检查烟草产品在地方之间的分布和监管 供应商，其商店是购买的关键点，与行业营销和促销联系， 可能用于FDA行动和产品风险的教育; 3）检查 烟草使用，将表型变量与文化和环境变量相结合，以确定 今后的烟草控制举措可针对不同的弱势群体。为了达到研究目的， 沿着培训活动，将提供证据，增强FDA的影响力， 公共卫生使用基于监管和教育的策略。这项研究承认， FDA行动和行业反应之间的相互作用，并探讨这些动态在脆弱的 人口数量。

This application for a Tobacco Center of Regulatory Science (TCORS) from the University of Southern California (USC) addresses the cross-ciutting theme of tobacco use among diverse populations, proposing an agenda of methods development and research that will assure that the activities of the Food and Drug Administration's (FDA) Center for Tobacco Products (CTP) reach many groups at risk for nicotine addiction and the adverse consequences of tobacco use. The proposed USC TCORS directly responds to RFA-DA-13- 003 with a highly experienced multi-disciplinary team of investigators who already work together on tobacco research in diverse populations considered vulnerable to tobacco use and addiction. These populations are distinguished by high and/or expanding tobacco use rates relative to other US populations, and may also be particularly vulnerable to tobacco use influences through tobacco industry marketing, social media communications, and cultural networks that present a tobacco use norm. There are three overall research aims of this TCORS: 1) evaluate marketing, social influence, social media, and network influences on tobacco use and product choice, emphasizing vulnerable populations, with the ultimate aim of identifying ways to reverse or counteract these influences; 2) examine tobacco product distribution and regulation among local vendors, whose stores are a key point for purchase, contact with industry marketing and promotion, and potentially for education about actions of the FDA and product risks; 3) examine different topographies of tobacco use, integrating phenotypic variables with cultural and environmental variables to determine how future tobacco control initiatives may be tailored to different vulnerable groups. Meeting the research aims, along with the training activities, will provide evidence that will enhance FDA's impact as it seeks to advance public health using strategies based in regulation and education. The research acknowledges the dynamic interplay between FDA actions and industry responses and explores these dynamics across vulnerable populations.