Interplay between Intrinsic and extrinsic force and glioma pathogenesis

内在和外在力量与神经胶质瘤发病机制之间的相互作用

• 批准号: 8741085
• 负责人: VALERIE MARIE WEAVER
• 金额: $ 10.99万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-26 至 2016-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8741085
• 关键词: Address; Adhesions; Adult; Aggressive behavior; Angiogenic Factor; Behavior; Biological; Biological Assay; Biology; Blood Vessels; Brain; Brain Neoplasms; Brain region; Cancer Biology; Cells; Cessation of life; Clinical; Collagen; Confined Spaces; Data; Deposition; Diagnosis; Diffusion; Environment; Extracellular Matrix; Fibronectins; Figs - dietary; Fostering; Funding; Glioblastoma; Glioma; Glycocalyx; Goals; Growth; Growth Factor; Histology; Human; Hyaluronic Acid; Image; In Vitro; Individual; Inflammation; Inflammatory; Integrins; Intracranial Hypertension; Knock-in Mouse; Knockout Mice; Link; Liquid substance; Magnetic Resonance Imaging; Malignant neoplasm of brain; Maps; Mechanics; Mediating; Molecular; Mus; PTK2 gene; Pathogenesis; Patient Care; Patients; Perfusion; Phenotype; Property; Proteins; Proteoglycan; Radiation therapy; Recurrence; Request for Proposals; Research; Resistance; Role; Sampling; Signal Transduction; Staging; Testing; Tissue Procurements; Tissues; Transgenic Mice; Transplantation; angiogenesis; base; brain cell; cellular imaging; chemokine; elastography; flexibility; improved; in vivo; interdisciplinary approach; interstitial; loss of function; mortality; neoplastic cell; nerve stem cell; notch protein; novel diagnostics; novel therapeutics; outcome forecast; physical science; pressure; prognostic; programs; stemness; trait; tumor

Adult brain cancer continues to be a significant challenge to clinicians and over 20,000 cases are diagnosed per year. Because the prognosis for individuals with glioblastoma, the most common type of brain cancer, remains poor, it is of critical importance that new therapies be developed. This proposal requests funds to support a research program that integrates physical sciences concepts and approaches with basic and clinical cancer biology research strategies to explore the role of cell intrinsic and external force in GBM aggression. The hope is that this interdisciplinary approach will offer a new paradigm with which to clarify the basis for the invasive and treatment resistant phenotype of high grade GBMs, and by so doing reveal new avenues for developing novel diagnostics, prognostics and therapies.

成人脑癌仍然是临床医生面临的重大挑战，每年诊断出的病例超过2万例。由于最常见的脑癌--胶质母细胞瘤患者的预后仍然很差，因此开发新的治疗方法至关重要。这项提案要求资金支持一项研究计划，该计划将物理科学的概念和方法与基础和临床癌症生物学研究策略相结合，以探索细胞内在和外部力量在GBM攻击中的作用。希望这种跨学科的方法将提供一个新的范例，用来阐明高级别GBM侵袭和治疗耐药表型的基础，并通过这样做揭示开发新的诊断、预后和治疗的新途径。