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2015 Fibronectin, Integrins & Related Molecules Gordon Research Conference & Gordon Research Seminar

2015 纤连蛋白、整合素

基本信息

批准号：
8908601
负责人：
VALERIE MARIE WEAVER
金额：
$ 1.92万
依托单位：
GORDON RESEARCH CONFERENCES
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-05-01 至 2016-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8908601
关键词：
Adhesions Animal Model Area Arthritis Behavior Biochemical Biological Models Cardiovascular Diseases Cell Nucleus Cell-Matrix Junction Cells Collaborations Complex Cues Cytoskeleton Development Disease Disease Progression ECM receptor Education Embryonic Development Engineering Epithelial-Stromal Communication Extracellular Matrix Fibronectins Fibrosis Fostering Government Homeostasis Infection Inflammation Inflammatory Integrins International Italy Knowledge Lead Life Malignant Neoplasms Mechanics Mentors Microscopy Modification Molecular Normal tissue morphology Organism Participant Pathology Postdoctoral Fellow Process Property Regulation Research Research Personnel Resort Role Scientist Signal Transduction Stem cells Structure Therapeutic Tissue Engineering Tissues Training Training and Education Translating Work Wound Healing abstracting biophysical analysis biophysical properties career cell behavior cohort data exchange experience graduate student human disease immune function insight mathematical model meetings member next generation novel therapeutic intervention novel therapeutics posters prevent programs public health relevance receptor receptor structure function stem cell fate symposium three-dimensional modeling tissue regeneration

项目摘要

DESCRIPTION (provided by applicant): We request partial support for the Fibronectin, Integrins and Related Molecules Gordon Research Conference and Gordon Research Seminar, May 9-15, 2015 at the Il Ciocco Hotel and Resort, Lucca, Italy. The primary objective of the conference is to increase understanding of how biophysical and biochemical cues from the extracellular matrix (ECM) regulate stem cell fate and modulate development and tissue homeostasis and how perturbations in this dialogue promote disease. We aim to delineate how fundamental molecular mechanisms regulating cell matrix adhesion and turnover, are regulated, and to understand how the molecules of the integrin adhesome are adapted to respond to and transduce mechanical force. Our second objective is to foster the careers of junior investigators and contribute to the education and training the next generation of scientists. Inclusion of the Gordon Research Seminar (GRS) preceding the Gordon Research Conference (GRC) provides an opportunity for trainees to present and discuss their research and obtain mentoring from established scientists. This allows valuable networking opportunities, and benefits the main GRC, as the cohort of those who have attended the GRS bring their excitement and enthusiasm to the GRC. The GRS and GRC aim to advance progress in the ECM adhesion area by bringing together diverse cell-ECM researchers and outside experts to share their latest work thereby stimulating new ideas and solving important problems in the field, generating new collaborations, sustaining and expanding the field, and developing new therapeutic opportunities. This will be achieved by convening a 2 day GRS and a 5 day GRC. The GRC includes 2 invited leaders in the field and 12 talks selected from up to 50 participants. The GRC will nucleate around 35 invited speakers that include 16 junior investigators and 10 outside speakers, who represent the cutting edge of current research in ECM adhesion and outside fields, supplemented with 8 selected short talks from the abstracts. Both programs hold poster sessions to maximize scientific discussion. The meetings will advance the field by: 1) integrating robust quantitative analysis, biophysical and engineering approaches, advanced microscopy and mathematical modeling to enhance understanding of molecular mechanisms regulating cell-ECM interactions, and 2) clarifying how ECM context, including biophysical and biochemical properties and dimensionality (3D) modulate cell and tissue fate dynamically focusing on stem cells and tissue development and disease using 3D model systems and organisms. By understanding how cell-ECM interactions regulate cell and tissue fate tissue engineering and regeneration will benefit and treatments aimed at diseases associated with corrupted ECM-receptor interactions will be optimized and new ones identified.