2015 Fibronectin, Integrins & Related Molecules Gordon Research Conference & Gordon Research Seminar

2015 纤连蛋白、整合素

• 批准号: 8908601
• 负责人: VALERIE MARIE WEAVER
• 金额: $ 1.92万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-05-01 至 2016-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8908601
• 关键词: Adhesions; Animal Model; Area; Arthritis; Behavior; Biochemical; Biological Models; Cardiovascular Diseases; Cell Nucleus; Cell-Matrix Junction; Cells; Collaborations; Complex; Cues; Cytoskeleton; Development; Disease; Disease Progression; ECM receptor; Education; Embryonic Development; Engineering; Epithelial-Stromal Communication; Extracellular Matrix; Fibronectins; Fibrosis; Fostering; Government; Homeostasis; Infection; Inflammation; Inflammatory; Integrins; International; Italy; Knowledge; Lead; Life; Malignant Neoplasms; Mechanics; Mentors; Microscopy; Modification; Molecular; Normal tissue morphology; Organism; Participant; Pathology; Postdoctoral Fellow; Process; Property; Regulation; Research; Research Personnel; Resort; Role; Scientist; Signal Transduction; Stem cells; Structure; Therapeutic; Tissue Engineering; Tissues; Training; Training and Education; Translating; Work; Wound Healing; abstracting; biophysical analysis; biophysical properties; career; cell behavior; cohort; data exchange; experience; graduate student; human disease; immune function; insight; mathematical model; meetings; member; next generation; novel therapeutic intervention; novel therapeutics; posters; prevent; programs; public health relevance; receptor; receptor structure function; stem cell fate; symposium; three-dimensional modeling; tissue regeneration

 DESCRIPTION (provided by applicant): We request partial support for the Fibronectin, Integrins and Related Molecules Gordon Research Conference and Gordon Research Seminar, May 9-15, 2015 at the Il Ciocco Hotel and Resort, Lucca, Italy. The primary objective of the conference is to increase understanding of how biophysical and biochemical cues from the extracellular matrix (ECM) regulate stem cell fate and modulate development and tissue homeostasis and how perturbations in this dialogue promote disease. We aim to delineate how fundamental molecular mechanisms regulating cell matrix adhesion and turnover, are regulated, and to understand how the molecules of the integrin adhesome are adapted to respond to and transduce mechanical force. Our second objective is to foster the careers of junior investigators and contribute to the education and training the next generation of scientists. Inclusion of the Gordon Research Seminar (GRS) preceding the Gordon Research Conference (GRC) provides an opportunity for trainees to present and discuss their research and obtain mentoring from established scientists. This allows valuable networking opportunities, and benefits the main GRC, as the cohort of those who have attended the GRS bring their excitement and enthusiasm to the GRC. The GRS and GRC aim to advance progress in the ECM adhesion area by bringing together diverse cell-ECM researchers and outside experts to share their latest work thereby stimulating new ideas and solving important problems in the field, generating new collaborations, sustaining and expanding the field, and developing new therapeutic opportunities. This will be achieved by convening a 2 day GRS and a 5 day GRC. The GRC includes 2 invited leaders in the field and 12 talks selected from up to 50 participants. The GRC will nucleate around 35 invited speakers that include 16 junior investigators and 10 outside speakers, who represent the cutting edge of current research in ECM adhesion and outside fields, supplemented with 8 selected short talks from the abstracts. Both programs hold poster sessions to maximize scientific discussion. The meetings will advance the field by: 1) integrating robust quantitative analysis, biophysical and engineering approaches, advanced microscopy and mathematical modeling to enhance understanding of molecular mechanisms regulating cell-ECM interactions, and 2) clarifying how ECM context, including biophysical and biochemical properties and dimensionality (3D) modulate cell and tissue fate dynamically focusing on stem cells and tissue development and disease using 3D model systems and organisms. By understanding how cell-ECM interactions regulate cell and tissue fate tissue engineering and regeneration will benefit and treatments aimed at diseases associated with corrupted ECM-receptor interactions will be optimized and new ones identified.

 描述（由申请人提供）：我们请求为 2015 年 5 月 9 日至 15 日在意大利卢卡 Il Ciocco 酒店和度假村举行的纤连蛋白、整合素和相关分子戈登研究会议和戈登研究研讨会提供部分支持。会议的主要目标是加深对细胞外基质 (ECM) 的生物物理和生化线索如何调节干细胞命运、调节发育和组织稳态以及这种对话中的扰动如何促进疾病的了解。我们的目标是描述调节细胞基质粘附和周转的基本分子机制是如何被调节的，并了解整合素粘附体的分子如何适应和转换机械力。我们的第二个目标是促进初级研究人员的职业生涯，并为教育和培训下一代科学家做出贡献。在戈登研究会议 (GRC) 之前举办的戈登研究研讨会 (GRS) 为学员​​提供了展示和讨论他们的研究并获得知名科学家指导的机会。这提供了宝贵的交流机会，并使主要的 GRC 受益，因为参加 GRS 的人群将他们的兴奋和热情带到了 GRC。 GRS 和 GRC 旨在通过汇集不同的细胞 ECM 研究人员和外部专家来分享他们的最新工作，从而推动 ECM 粘附领域的进展，从而激发新的想法并解决该领域的重要问题，产生新的合作，维持和扩展该领域，并开发新的治疗机会。这将通过召开为期 2 天的 GRS 和为期 5 天的 GRC 来实现。 GRC 包括 2 名受邀的该领域的领导者以及从最多 50 名参与者中选出的 12 场演讲。 GRC 将邀请大约 35 名受邀演讲者，其中包括 16 名初级研究人员和 10 名外部演讲者，他们代表了 ECM 粘附和外部领域当前研究的前沿，并辅以摘要中精选的 8 场简短演讲。这两个项目都举办海报会议，以最大限度地进行科学讨论。这些会议将通过以下方式推进该领域的发展：1) 整合稳健的定量分析、生物物理和工程方法、先进的显微镜和数学模型，以增强对调节细胞-ECM相互作用的分子机制的理解；2) 阐明 ECM 环境（包括生物物理和生化特性以及维度 (3D)）如何动态调节细胞和组织命运，重点关注干细胞和组织发育以及使用 3D 模型的疾病 系统和有机体。通过了解细胞-ECM 相互作用如何调节细胞和组织的命运，组织工程和再生将受益，并且针对与 ECM-受体相互作用受损相关的疾病的治疗将得到优化，并确定新的治疗方法。