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Controlling and preventing Asthma progression and Severity in Kids (CASK)

控制和预防儿童哮喘进展和严重程度 (CASK)

基本信息

批准号：
10431970
负责人：
WANDA PHIPATANAKUL
金额：
$ 274.08万
依托单位：
BOSTON CHILDREN'S HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-07-20 至 2024-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10431970
关键词：
3 year old Adult Affect Aftercare Age Allergens Allergic Antibodies Antibody Formation Asthma Attenuated Birth Child Childhood Childhood Asthma Chronic Cohort Studies Cost of Illness Delayed Hypersensitivity Development Diagnosis Disease Disease Progression Double-Blind Method Environmental Exposure Exposure to Financial Hardship Funding Future Hospitalization IgE Immune response Impairment Inflammation Interferon alpha Interleukin-13 Interleukin-4 Interleukin-5 Intervention Life Lower Respiratory Tract Infection Mediating Morbidity - disease rate National Institute of Allergy and Infectious Disease Natural History Participant Pathway interactions Pharmaceutical Preparations Phenotype Placebo Control Placebos Predisposition Prevalence Prevention Production Protocols documentation Public Health Quality of life Randomized Reaction Regulatory T-Lymphocyte Research Personnel Rhinovirus Risk Risk Factors Role Sampling School-Age Population Seasons Severities Signal Transduction Societies Source Steroids T-Lymphocyte Testing United States Viral Virus Diseases Wheezing Wit aged airborne allergen anti-IgE asthma exacerbation asthma prevention cohort cost crosslink cytokine design disability early childhood environmental allergen health care service utilization high risk mast cell mortality novel strategies omalizumab prevent primary outcome response secondary outcome treatment group

项目摘要

Project Summary/Abstract Asthma remains one of the most important challenges to pediatric public health in the US, affecting millions of children, causing significant morbidity, mortality, and source of tremendous financial burden. Prevention of asthma is a pressing, unmet need of utmost priority. The vast majority of children with persistent and chronic asthma demonstrate aeroallergen sensitization (IgE antibody production), which remains the pivotal risk factor for developing persistent, progressive asthma throughout life. It has recently been shown that aeroallergen sensitization precedes viral wheezing and is the pivotal causal pathway and essential susceptibility factor in the persistence and progression of the disease. Most aeroallergen sensitization begins around the age of 2-3 years and escalates during school age. The progression appears to be dependent on exposures to offending allergens-- the greatest increase in development and impairment from asthma is seen in those with a tendency toward Type 2 inflammation who are sensitized and exposed to high levels of offending allergens. In addition to its role in mediating allergen-induced responses, IgE signals impair innate anti-viral immune responses which could lead to increased viral infections and thus potentially further enhance the cascade of progression to asthma. Omalizumab (anti-IgE) markedly reduces asthma exacerbations during the viral season and anti- IgE treated children have demonstrated restored IFN-α response to rhinovirus. This suggests that anti-IgE prevents IgE driven responses to offending allergen exposure in those with a Type 2 phenotype AND attenuates viral infections in this Type 2 phenotype. Thus, utilizing anti-IgE in young children has the potential to prevent the development of established asthma in susceptible children by blocking all IgE allergen-antibody interactions (including responses to subclinical exposures) AND by reducing the response to viral exposure which may lead to asthma. We hypothesize that blockade of IgE in young children (age 2-3) at high risk for development of asthma will prevent progression to established asthma. We will test this hypothesis by examining the effect of anti-IgE on the development of asthma in a double-blind, randomized, placebo- controlled parallel trial of anti-IgE vs placebo in 250 children aged 2-3 years old at high risk of developing asthma, who will be followed for 2 years after 2 years of therapy is discontinued. Primary outcome will be the proportion of participants with current, active asthma as defined in the NIAID URECA birth cohort, between the two treatment groups at the end of Year 4, the final 12 months of the trial off study medication. Secondary outcomes will include occurrence of wheezing episodes, exacerbations requiring steroids, and new and persistent allergen-specific IgE sensitizations after IgE therapy. If confirmed, anti-IgE therapy would be the first intervention to change the natural history of childhood asthma. This trial will not only allow us to expand our understanding of asthma immunopathogenesis, but will also create opportunities to identify IgE mediated and other novel approaches impacting our understanding towards preventing the disease.

项目总结/摘要哮喘仍然是美国儿科公共卫生面临的最重要挑战之一，影响着数百万儿童。儿童，造成重大的发病率，死亡率和巨大的经济负担的来源。预防哮喘是一个迫切的、未得到满足的最优先需要。绝大多数患有持续性和慢性哮喘表现为吸入性过敏原致敏（IgE抗体产生），这仍然是关键的危险因素在一生中发展为持续性、进行性哮喘。最近的研究表明，致敏先于病毒性喘鸣，是哮喘的关键致病途径和重要易感因素。疾病的持续和发展。大多数空气过敏原致敏开始于2-3岁左右年，并在学龄期间升级。这种进展似乎取决于对犯罪的暴露程度过敏原--哮喘的发展和损害的最大增加见于那些有对2型炎症的敏感性和暴露于高水平的攻击性过敏原。此外 IgE信号在介导过敏原诱导的应答中的作用，这可能导致病毒感染增加，从而可能进一步增强疾病的级联反应，哮喘。奥马珠单抗（抗IgE）在病毒季节显著降低哮喘急性发作， IgE治疗的儿童表现出对鼻病毒的IFN-α应答恢复。这表明抗IgE 在具有2型表型的人中防止IgE驱动的对冒犯性变应原暴露的反应，减弱这种2型表型的病毒感染。因此，在幼儿中使用抗IgE抗体具有潜力，通过阻断所有IgE过敏原抗体，预防易感儿童发生哮喘相互作用（包括对亚临床暴露的反应）和降低对病毒暴露的反应可能导致哮喘我们假设，在高风险的幼儿（2-3岁）中阻断IgE，哮喘的发展将防止进展为已建立的哮喘。我们将通过以下方式检验这一假设：在一项双盲、随机、安慰剂研究中，抗IgE抗体与安慰剂在250名2-3岁高危儿童中的平行对照试验哮喘，停止2年治疗后将对其进行2年随访。主要结果将是在NIAID URECA出生队列中定义的当前活动性哮喘受试者比例，两个治疗组在第4年结束时，试验的最后12个月停止研究药物。二次结果将包括喘息发作的发生，需要类固醇的加重，以及新的和 IgE治疗后持续的过敏原特异性IgE致敏。如果得到证实，抗IgE治疗将是第一个干预以改变儿童哮喘的自然史。这次审判不仅能让我们扩大了解哮喘免疫发病机制，但也将创造机会，以确定IgE介导的，其他新的方法影响我们对预防疾病的理解。

项目成果

期刊论文数量（30）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Modeling indoor particulate exposures in inner-city school classrooms.

DOI：
10.1038/jes.2016.52
发表时间：
2017-09
期刊：
Journal of exposure science & environmental epidemiology
影响因子：
4.5
作者：
Gaffin JM;Petty CR;Hauptman M;Kang CM;Wolfson JM;Abu Awad Y;Di Q;Lai PS;Sheehan WJ;Baxi S;Coull BA;Schwartz JD;Gold DR;Koutrakis P;Phipatanakul W
通讯作者：
Phipatanakul W

Recent advances in environmental controls outside the home setting.

DOI：
10.1097/aci.0000000000000250
发表时间：
2016-04
期刊：
Current opinion in allergy and clinical immunology
影响因子：
2.8
作者：
Hauptman M;Phipatanakul W
通讯作者：
Phipatanakul W

Impact of school peanut-free policies on epinephrine administration.

DOI：
10.1016/j.jaci.2017.01.040
发表时间：
2017-08
期刊：
The Journal of allergy and clinical immunology
影响因子：
0
作者：
Bartnikas LM;Huffaker MF;Sheehan WJ;Kanchongkittiphon W;Petty CR;Leibowitz R;Hauptman M;Young MC;Phipatanakul W
通讯作者：
Phipatanakul W

Treatment of moderate to severe pediatric asthma: Omalizumab and potential future use of monoclonal antibodies.

中度至重度小儿哮喘的治疗：奥马珠单抗和单克隆抗体的未来潜在用途。