Midcareer Investigator Award: Urban School Allergen Exposures and Childhood Asthm

职业生涯中期调查员奖：城市学校过敏原暴露和儿童哮喘

• 批准号: 9064061
• 负责人: WANDA PHIPATANAKUL
• 金额: $ 18.31万
• 依托单位: BOSTON CHILDREN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-06-01 至 2018-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9064061
• 关键词: Accounting; Address; Affect; Age; Allergens; Allergic Disease; Americas; Asthma; Award; Blood; Cells; Child; Childhood; Childhood Asthma; Clinical; Clinical Research; Collaborations; Communities; DNA; DNA Methylation; Data; Education; Ensure; Environment; Environmental Exposure; Environmental Risk Factor; Epigenetic Process; Epithelial Cells; Event; Exposure to; Extrinsic asthma; FOXP3 gene; Fostering; Funding; Gender; Genes; Genetic; Goals; Health; Home environment; Hypersensitivity; Immunologist; Incidence; Inflammation Mediators; Inflammatory; Interferons; Interleukin-6; Intervention; Link; Mediating; Mentors; Methylation; Molds; Molecular; Morbidity - disease rate; NOS2A gene; National Institute of Allergy and Infectious Disease; Nose; Outcome; Pathogenesis; Pathway interactions; Public Health; Research; Research Activity; Research Design; Research Infrastructure; Research Personnel; Resources; Risk Factors; Role; Running; Schools; Serum; Severities; Source; Statistical Methods; Students; Symptoms; Time; United States; United States National Institutes of Health; Wheezing; airway inflammation; allergic airway disease; allergic airway inflammation; base; career development; cell type; clinical epidemiology; cohort; cost; design; environmental intervention; environmental stressor; gene environment interaction; immunoregulation; improved; inner city; innovation; methylation biomarker; novel marker; patient oriented; patient oriented research; primary outcome; programs; public health relevance; response

DESCRIPTION (provided by applicant): Childhood asthma, particularly in urban environments, is a source of significant morbidity. Children spend the majority of their day in school. The immediate goal of this project is to determine the role of changes in school-specific environmental exposures and genetic factors and asthma morbidity. The Candidate/PI is a board-certified allergist/immunologist with a MS in clinical epidemiology and runs a NIH funded asthma/allergy clinical research center. She has expertise in patient-oriented clinical research and mentoring. Her environment includes unparalleled community relationships, infrastructure, resources, and collaborators. Career Development Goals are to ensure that the candidate will be provided sufficient time for mentoring and patient oriented clinical research activities. The award will also allow her to further her education in statistical methods, study design, and gene-environment interactions to help her expand her patient oriented research program. This will allow us to move towards our overall goal of further our understanding of epigenetic/environmental interactions to design and implement more effective school focused interventions to reduce the severity and incidence of childhood asthma. The research hypothesis is that changes in classroom/school specific allergen/mold exposure levels will be associated with epigenetic changes in methylation, airway inflammation, and asthma symptoms. We will compare our methylation markers on selected genes potentially important in asthma with changes in the classroom-specific allergen/mold exposure and asthma health outcomes. We will also compare these results in a subset of age/gender matched students without asthma as controls attending the same classrooms to further the interpretation of our findings. The impact of this research may result in novel biomarkers that could inform us about the efficacy of school-based interventions against environmental exposures important to childhood asthma and its immune modulation, addressing a critical public health problem.

描述（由申请人提供）：儿童哮喘，特别是在城市环境中，是显着发病的一个来源。孩子们一天的大部分时间都在学校度过。该项目的近期目标是确定学校特定环境暴露和遗传因素以及哮喘发病率变化的作用。候选人/PI 是一位经过委员会认证的过敏症专家/免疫学家，拥有临床流行病学硕士学位，并经营着一个由 NIH 资助的哮喘/过敏症临床研究中心。她拥有以患者为导向的临床研究和指导方面的专业知识。她的环境包括无与伦比的社区关系、基础设施、资源和合作者。职业发展目标是确保候选人有足够的时间进行指导和以患者为导向的临床研究活动。该奖项还将使她能够继续深造统计方法、研究设计和基因-环境相互作用方面的教育，以帮助她扩大以患者为导向的研究项目。这将使我们能够朝着进一步了解表观遗传/环境相互作用的总体目标迈进，以设计和实施更有效的以学校为重点的干预措施，以降低儿童哮喘的严重程度和发病率。研究假设是，课堂/学校特定过敏原/霉菌暴露水平的变化将与甲基化、气道炎症和哮喘症状的表观遗传变化相关。我们将比较对哮喘可能重要的选定基因的甲基化标记与课堂特定过敏原/霉菌暴露和哮喘健康结果的变化。我们还将比较年龄/性别匹配的无哮喘学生的子集的这些结果，作为参加同一教室的对照组，以进一步解释我们的研究结果。这项研究的影响可能会产生新的生物标志物，这些生物标志物可以让我们了解基于学校的干预措施对儿童哮喘及其免疫调节很重要的环境暴露的有效性，从而解决一个关键的公共卫生问题。