Electronic Access to Mouse Tumor Data

小鼠肿瘤数据的电子获取

• 批准号: 8258785
• 负责人: CAROL J BULT
• 金额: $ 79.33万
• 依托单位: JACKSON LABORATORY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-01-10 至 2015-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8258785
• 关键词: Affect; Aging; Alleles; Animal Cancer Model; Animal Model; Atlases; Base Sequence; Biological; Biological Models; Biology; Biomedical Research; Cancer Biology; Characteristics; Cohort Studies; Collection; Communities; Community Outreach; Computer software; Correlative Study; Data; Data Aggregation; Data Set; Databases; Development; Diagnosis; Diagnostic; Diagnostic Imaging; Disease; Disease model; Electronics; Engineering; Evaluation; Experimental Models; Frequencies; Gene Expression; Gene Targeting; Gene Transfer Techniques; Genes; Genetic; Genetic Models; Genetic Research; Genetically Engineered Mouse; Genome; Genome Mappings; Genomic Instability; Genomics; Genotype; Goals; Grant; Histopathology; Human; Human Biology; Hyperplasia; Hypertrophy; Image; Imagery; Inbred Strains Mice; Inbreeding; Incidence; Informatics; Israel; Laboratory mice; Link; Loss of Heterozygosity; Maintenance; Malignant Neoplasms; Medicine; Metadata; Mining; Molecular; Mouse Strains; Mus; Mutate; Mutation; Neoplasm Metastasis; Neoplasms; Oncogenes; Pathologist; Pathology; Pattern; Play; Point Mutation; Predisposition; Process; Public Health; Quantitative Trait Loci; Reporting; Research; Research Infrastructure; Research Personnel; Resource Informatics; Resources; Role; Scientist; Services; Source; Spectral Karyotyping; Swelling; System; Techniques; Tissues; Tumor Biology; United States National Institutes of Health; Ursidae Family; abstracting; anticancer research; base; cancer Biomedical Informatics Grid; cancer genetics; cancer genome; cancer genomics; cancer initiation; comparative genomic hybridization; data acquisition; data mining; design; genetic profiling; genome-wide; human cancer mouse model; improved; indexing; innovation; insight; knowledge base; mouse model; mutant; neoplastic; novel; repository; research study; response; symposium; tool; tumor; tumor progression; tumorigenesis; usability; web interface; web services; web site

Project Summary/Abstract Our overall goal is to develop an informatics infrastructure essential for supporting basic cancer genetics research using the mouse as a model system for human cancer. The Mouse Tumor Biology (MTB) Database (http://tumor.informatics.jax.org) is a primary resource for researchers seeking integrated information on the frequency, incidence, genetics, and pathology of neoplastic disorders in mice. In addition, selected data from MTB make up the vast majority of data available via the animal models of cancer database (caMOD) that is a core component of NCI's cancer biomedical informatics grid (caBIG) project. MTB emphasizes data on tumors that develop characteristically in different genetically defined strains of mice (inbred, mutant, and genetically engineered) that serve as disease models for human cancers. MTB provides data to assist in selection of strains for experimentation and is a platform for mining data on tumor development and patterns of metastases. We now propose to build on this resource. Specifically: ¿ We will continue to populate MTB with data on strain-specific patterns of tumorigenesis in inbred, mutant, and genetically engineered mice, including data on tumor diagnoses and pathology images. ¿ We will integrate new data types into MTB that further contribute to characterization of mouse models for human cancer, including indexing data from gene expression arrays, incorporating data sets from large mouse cohort studies, and including results from large-scale human cancer genomics, such as the NIH Cancer Genome Atlas Project. ¿ We will enhance access to MTB data using interactive graphical tools, and provide new genome-wide views of specific genetic changes and quantitative trait loci (QTL) associated with tumorigenesis and sequence-based genome views that are integrated with cancer-biology information. ¿ We will develop a new paradigm for MTB that matches common user workflows to select and refine data sets. ¿We will support the infrastructure of MTB through database maintenance, development of new software components, user support services, and community outreach activities and provide new tools for programmatic access to MTB and SQL access for computational users. Our objective is to provide the user with current data about mouse models for human cancer and provide tools for exploring and exploiting MTB data to inspire new hypotheses that may provide novel insights into the process of cancer initiation and progression.

项目总结/摘要 我们的总体目标是发展一个支持基本癌症遗传学的信息学基础设施 使用小鼠作为人类癌症模型系统的研究。小鼠肿瘤生物学（MTB）数据库 (http：//www.example.com）是研究人员寻求综合信息的主要资源， 小鼠肿瘤疾病的频率、发病率、遗传学和病理学。此外，从以下数据中选择数据： MTB构成了癌症动物模型数据库（caMOD）的绝大多数数据， NCI癌症生物医学信息网格（caBIG）项目的核心组成部分。MTB强调肿瘤数据 在不同的遗传定义的小鼠品系（近交系、突变系和遗传定义的小鼠品系）中特征性地发育， 工程化的），其用作人类癌症的疾病模型。MTB提供数据以帮助选择 菌株进行实验，是一个平台，用于挖掘肿瘤发展和肿瘤模式的数据。 转移 我们现在建议利用这一资源。具体而言： 我们将继续用近交系，突变体， 和基因工程小鼠，包括肿瘤诊断和病理图像的数据。 我们将把新的数据类型整合到MTB中，进一步促进小鼠模型的表征， 人类癌症，包括从基因表达阵列索引数据，纳入数据集，从大型 小鼠队列研究，包括来自大规模人类癌症基因组学的结果，如NIH 癌症基因组图谱计划。 我们将使用交互式图形工具增强对MTB数据的访问，并提供新的全基因组 与肿瘤发生相关的特定遗传变化和数量性状位点（QTL）的观点， 基于序列的基因组视图与癌症生物学信息相结合。 我们将为山地车开发一种新的模式，与常见的用户工作流程相匹配，以选择和优化数据 集. 我们将通过数据库维护、新软件开发等方式支持曼恩商用车公司的基础设施。 组件、用户支持服务和社区外展活动，并提供新的工具， 编程访问MTB和SQL访问计算用户。 我们的目标是为用户提供有关人类癌症小鼠模型的最新数据，并提供工具 探索和利用山地车数据，激发新的假设，可能提供新的见解， 癌症发生和发展的过程。