Alcohol intervention in men with HIV in Baltimore

巴尔的摩对艾滋病毒感染者的酒精干预

• 批准号: 8262220
• 负责人: Cui Yang
• 金额: $ 15.08万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-10 至 2014-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8262220
• 关键词: 18 year old; AIDS prevention; Address; Affect; Alcohol consumption; Alcohols; Attention; Baltimore; Behavior; China; Chinese People; Cities; Client; Coitus; Communication; Counseling; Country; Data; Development; Eligibility Determination; Female; Focus Groups; Fostering; Friends; Funding; Future; Gifts; Goals; Grant; HIV; HIV Infections; HIV prevention trials network; Health Educators; Heterosexuals; Human immunodeficiency virus test; Individual; Industry; Intervention; Interview; Knowledge; Measurement; Measures; Mediating; Mentors; National Institute of Allergy and Infectious Disease; Outcome; Participant; Pattern; Phase; Pilot Projects; Population; Population Research; Prevention strategy; Preventive Intervention; Probability; Prostitution; Protocols documentation; Province; Qualitative Methods; Randomized Controlled Trials; Recruitment Activity; Reporting; Research; Risk; Risk Behaviors; Role; Science; Sex Behavior; Sexual Health; Sexual Partners; Social Behavior; Social Environment; Social Network; Statistical Methods; Testing; Time; Training; Translations; Unsafe Sex; Visit; Woman; Yang; alcohol behavior; alcohol intervention; alcohol risk; alcohol risk reduction; base; behavior change; career; comparison group; design; drinking; follow-up; high risk; high risk sexual behavior; male; member; men; men who have sex with men and women; men' s group; outreach; peer; prevent; reduced alcohol use; sex; sex risk; skills; social; standard care; therapy development; transmission process

DESCRIPTION (provided by applicant): Dr. Cui Yang's long term career goal is to develop interventions to address alcohol use and risky HIV related behaviors among high-risk populations. There is an urgent need for the development of culturally-tailored intervention to reduce HIV infections among men who have sex with men and women (MSMW), a high priority population identified in the recent national plan for reducing HIV infection. This K99/ROO application is therefore uniquely timed to contribute to a growing field of HIV prevention science. Overseen by a team of mentors, Dr. Yang's training objectives include 1) To gain expertise in alcohol risk-reduction interventions, 2) To enhance knowledge of alcohol use measurement among high risk populations; and 3) To further develop skills in qualitative methods and application of advanced statistical methods. In the mentored phase research (K99), Dr. Yang will conduct both qualitative (n=40) and quantitative interviews with 40 participants recruited from Baltimore, MD to 1) explore the social factors associated with alcohol use in the context of high risk sex behaviors, 2) to examine the feasibility of peer-driven intervention, and 3) to develop reliable and valid measures of alcohol use. The training objectives and mentored phase research are instrumental to the successful advancement to the ROO phase research which proposes to develop intervention materials and will compare outcomes between two study conditions: (1) standard individual voluntary counseling and testing (VCT) (n=100), and (2) experimental condition (n=100). In the experimental condition, participants will be trained in the reduction of alcohol use and sexual risk behaviors, peer outreach, and communication skills so that they can conduct HIV prevention and alcohol reduction outreach among their risk network members. Participants in the comparison group will receive the standard care of HIV testing and counseling. All participants will be assessed at baseline and 6-month follow up. Finding of this pilot peer-driven intervention will provide significant preliminary data for an R01 grant of a prevention intervention to address issues of sexual health and alcohol-related risks among men who have HIV or at a higher risk of acquiring HIV. PUBLIC HEALTH RELEVANCE: The proposed intervention described in this application is to train affected men as peer health educators to promote the reduction of alcohol use and risky behavior that could prevent or reduce the transmission of HIV among men and women. Results from this intervention will inform future peer-driven interventions and the translation of such an intervention to the other settings, where alcohol and risky behaviors often co-occur.

描述(申请人提供)：崔阳博士的长期职业目标是开发干预措施，以解决高危人群中的酒精使用和与艾滋病毒相关的高风险行为。迫切需要制定有文化针对性的干预措施，以减少男男性和女性性行为者(MSMW)的艾滋病毒感染，MSMW是最近的国家减少艾滋病毒感染计划中确定的高度优先人群。因此，这一K99/Roo应用程序的时机是独特的，以促进艾滋病毒预防科学领域的发展。 在导师团队的监督下，杨博士的培训目标包括1)获得减少酒精风险干预方面的专业知识，2)提高高危人群酒精使用测量的知识，3)进一步发展定性方法和先进统计方法的应用技能。在指导阶段研究(K99)中，杨博士将对从马里兰州巴尔的摩招募的40名参与者进行定性(n=40)和定量访谈，以1)探索在高风险性行为背景下与酒精使用相关的社会因素，2)检查同伴驱动干预的可行性，以及3)开发可靠和有效的酒精使用措施。培训目标和指导阶段研究有助于成功推进到Roo阶段研究，该阶段研究建议开发干预材料，并将比较两种研究条件下的结果：(1)标准个人自愿咨询和测试(VCT)(n=100)，和(2)实验条件(n=100)。在实验条件下，参与者将接受减少饮酒和性危险行为、同伴接触和沟通技能方面的培训，以便他们能够在风险网络成员中进行艾滋病毒预防和减少酒精接触。对照组的参与者将接受艾滋病毒检测和咨询的标准护理。所有参与者将在基线和6个月的随访时进行评估。这一试验性同行驱动干预的发现将为R01批准预防干预提供重要的初步数据，以解决艾滋病毒携带者或感染艾滋病毒风险较高的男性的性健康和与酒精有关的风险问题。 公共卫生相关性：本申请中描述的拟议干预措施是将受影响的男性培训为同行健康教育者，以促进减少饮酒和可能防止或减少艾滋病毒在男性和女性之间传播的危险行为。这种干预的结果将为未来的同行驱动的干预提供信息，并将这种干预转化为其他环境，在其他环境中，酒精和危险行为经常同时发生。