Alcohol intervention in men with HIV in Baltimore

描述（由申请人提供）：崔阳博士的长期职业目标是开发干预措施，以解决高危人群中的酒精使用和危险的艾滋病毒相关行为。迫切需要制定针对文化的干预措施，以减少男男性行为者和女男性行为者的艾滋病毒感染，这是最近减少艾滋病毒感染的国家计划中确定的高度优先人群。因此，K99/ROO应用程序的时机非常独特，有助于不断发展的艾滋病毒预防科学领域。 在导师团队的监督下，杨博士的培训目标包括：1）获得减少酒精风险干预措施的专业知识; 2）提高高危人群中酒精使用测量的知识; 3）进一步发展定性方法和先进统计方法的应用技能。在指导阶段研究（K99）中，杨博士将对从马里兰州巴尔的摩招募的40名参与者进行定性（n=40）和定量访谈，以1）探索在高危性行为背景下与酒精使用相关的社会因素，2）检查同伴驱动干预的可行性，3）制定可靠有效的酒精使用措施。培训目标和指导阶段研究有助于成功推进ROO阶段研究，该研究提出开发干预材料，并将比较两种研究条件之间的结果：（1）标准个人自愿咨询和测试（VCT）（n=100），（2）实验条件（n=100）。在实验条件下，参与者将接受减少饮酒和性风险行为、同伴外联和沟通技巧的培训，以便他们能够在风险网络成员中开展艾滋病毒预防和减少饮酒的外联活动。对照组的参与者将接受艾滋病毒检测和咨询的标准护理。所有参与者将在基线和6个月随访时进行评估。这项同伴驱动的试点干预措施的发现将为R 01预防干预赠款提供重要的初步数据，以解决感染艾滋病毒或感染艾滋病毒风险较高的男性的性健康和酒精相关风险问题。

DESCRIPTION (provided by applicant): Dr. Cui Yang's long term career goal is to develop interventions to address alcohol use and risky HIV related behaviors among high-risk populations. There is an urgent need for the development of culturally-tailored intervention to reduce HIV infections among men who have sex with men and women (MSMW), a high priority population identified in the recent national plan for reducing HIV infection. This K99/ROO application is therefore uniquely timed to contribute to a growing field of HIV prevention science. Overseen by a team of mentors, Dr. Yang's training objectives include 1) To gain expertise in alcohol risk-reduction interventions, 2) To enhance knowledge of alcohol use measurement among high risk populations; and 3) To further develop skills in qualitative methods and application of advanced statistical methods. In the mentored phase research (K99), Dr. Yang will conduct both qualitative (n=40) and quantitative interviews with 40 participants recruited from Baltimore, MD to 1) explore the social factors associated with alcohol use in the context of high risk sex behaviors, 2) to examine the feasibility of peer-driven intervention, and 3) to develop reliable and valid measures of alcohol use. The training objectives and mentored phase research are instrumental to the successful advancement to the ROO phase research which proposes to develop intervention materials and will compare outcomes between two study conditions: (1) standard individual voluntary counseling and testing (VCT) (n=100), and (2) experimental condition (n=100). In the experimental condition, participants will be trained in the reduction of alcohol use and sexual risk behaviors, peer outreach, and communication skills so that they can conduct HIV prevention and alcohol reduction outreach among their risk network members. Participants in the comparison group will receive the standard care of HIV testing and counseling. All participants will be assessed at baseline and 6-month follow up. Finding of this pilot peer-driven intervention will provide significant preliminary data for an R01 grant of a prevention intervention to address issues of sexual health and alcohol-related risks among men who have HIV or at a higher risk of acquiring HIV.