Alcohol intervention in men with HIV in Baltimore

巴尔的摩对艾滋病毒感染者的酒精干预

• 批准号: 8894846
• 负责人: Cui Yang
• 金额: $ 24.9万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-10 至 2017-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8894846
• 关键词: 18 year old; AIDS prevention; Address; Alcohol consumption; Alcohols; Attention; Baltimore; Behavioral; China; Chinese People; Cities; Client; Coitus; Communication; Counseling; Country; Data; Development; Eligibility Determination; Epidemiology; Female; Focus Groups; Fostering; Friends; Funding; Gifts; Goals; Grant; HIV; HIV Infections; HIV prevention trials network; HIV risk; Health Educators; Heterosexuals; Human immunodeficiency virus test; Individual; Industry; Intervention; Interview; Knowledge; Language; Mediating; Mentors; National Institute of Allergy and Infectious Disease; Outcome; Participant; Pattern; Phase; Pilot Projects; Population; Population Research; Positioning Attribute; Prevention strategy; Preventive Intervention; Probability; Prostitution; Protocols documentation; Province; Qualitative Methods; Randomized Controlled Trials; Recording of previous events; Reporting; Research; Risk; Risk Behaviors; Risk Reduction; Role; Science; Sex Behavior; Sexual Health; Sexual Partners; Social Behavior; Social Environment; Social Network; Statistical Methods; Testing; Time; Training; Translations; United States; Unsafe Sex; Visit; Yang; alcohol intervention; alcohol risk; base; behavior change; career; comparison group; design; drinking; follow-up; high risk; high risk sexual behavior; male; member; men; men' s group; outreach; peer; reduced alcohol use; sex; skills; social; social norm; standard care; therapy design; therapy development; transmission process

7. PROJECT SUMMARY/ABSTRACT Dr. Cui Yang's long term career goal is to develop culturally appropriate interventions among high-risk populations. Dr. Yang's history as an individual who has been trained in behavioral and epidemiological sciences in the United States, yet who understands Chinese culture and languages, places her in a strong position to contribute to a growing field of global collaborative research in HIV prevention. Since 2007, heterosexual transmission has become the major transmission mode of all HIV infections in China. In addition, alcohol use in conjunction with sexual activity increases the probability of risky sexual behaviors. There is an urgent need for the development of culturally-tailored intervention designed to reduce HIV infections among heterosexual men who are daily drinkers and have high risk sex partners, a understudied and yet a critical “bridge” group who could dramatically facilitate the spread of HIV. Little is known about social network factors of heterosexual men who have high risk sex partners, and there is an insufficient research on high risk heterosexual men and their alcohol consumption. This K99/R00 application is therefore uniquely timed to contribute to a growing field of HIV prevention science. Results from this pilot intervention will inform the social and cultural considerations of peer-driven interventions among male daily drinkers who have high risk sex partners and the translation of such an intervention to other countries, including US, where alcohol and risky sexual behaviors often co-occur. Overseen by a team of mentors, Dr. Yang's training objectives include 1) To gain expertise in HIV risk-reduction interventions, 2) To enhance knowledge of alcohol use among high risk populations; and 3) To further develop skills in qualitative methods and application of advanced statistical methods. In the mentored phase research (K99), Dr. Yang will conduct in-depth interviews among 40 male daily drinkers who have high risk sex partners to explore the factors associated with alcohol use in the context of high risk sex behaviors, and to examine the feasibility of peer-driven intervention in Sichuan province China. The training objectives and mentored phase research are instrumental to the successful advancement to the R00 phase research which proposes to develop intervention materials and will compare outcomes between two study conditions: (1) standard individual voluntary counseling and testing (VCT) (n=80), and (2) experimental condition (n=80). In the experimental condition, male daily drinkers who have high risk sex partners will be trained in the reduction of alcohol use and sexual risks, peer outreach, and communication skills so that they can conduct HIV prevention outreach among their risk network members. Participants in the comparison group will receive the standard care of HIV testing and counseling. All participants will be assessed at baseline and 6-month follow up. Finding of this pilot peer-driven intervention will provide significant preliminary data for an R01 grant of a prevention intervention to address issues of sexual health and alcohol- related risks among male daily drinkers who have high risk sex partners.

7.项目总结/摘要 崔阳博士的长期职业目标是在高危人群中开发文化上合适的干预措施。 人口。杨医生作为一个受过行为学和流行病学培训的人的历史 美国的科学，但谁了解中国文化和语言，她在一个强大的地方， 在艾滋病预防方面，全球合作研究领域不断扩大，我们有能力为这一领域做出贡献。自2007年以来， 异性传播已成为中国所有艾滋病感染者的主要传播方式。此外，本发明还提供了一种方法， 饮酒与性活动结合会增加危险性行为的可能性。有一个 迫切需要制定针对文化的干预措施，以减少艾滋病毒感染， 异性恋男性每天饮酒，并有高风险的性伴侣，这是一个未被充分研究，但也是一个关键的 “桥梁”群体，他们可以极大地促进艾滋病毒的传播。人们对社会网络因素知之甚少 有高风险性伴侣的异性恋男性，并且对高风险性伴侣的研究不足 异性恋男性和他们的饮酒量。因此，此K99/R 00应用程序的时间是唯一的， 为艾滋病预防科学领域的发展做出了贡献。这项试点干预的结果将告知社会 在有高风险性行为的男性每日饮酒者中进行同伴驱动干预的文化考虑 合作伙伴和翻译这样的干预其他国家，包括美国，在那里酒精和风险 性行为经常同时发生。在导师团队的监督下，杨博士的培训目标包括：1） 获得减少艾滋病毒风险干预措施的专门知识，2）提高高危人群对酒精使用的认识 3）进一步发展定性方法和应用先进统计方法的技能， 方法.在辅导阶段研究（K99）中，杨博士将对40名男性进行深入访谈， 每日饮酒者中有高风险性伴侣的人，以探讨在此背景下与饮酒相关的因素 的高危性行为，并探讨在中国四川省的同伴驱动的干预的可行性。 培训目标和指导阶段的研究有助于成功地推进到 R 00阶段研究，建议制定干预材料，并将比较 两种研究条件：（1）标准个人自愿咨询和检测（VCT）（n=80），和（2） 实验条件（n=80）。在实验条件下，男性每天饮酒者，有高危性行为， 合作伙伴将接受减少饮酒和性风险、同伴外联和沟通方面的培训 这些组织还将提高其技能，以便能够在其风险网络成员中开展艾滋病毒预防外联活动。参与者 对照组将接受标准护理的艾滋病病毒检测和咨询。所有参与者都有 在基线和6个月随访时进行评估。这项同行驱动的试点干预措施的发现将提供重要的 为解决性健康和酗酒问题而提供的R 01预防干预赠款的初步数据- 有高风险性伴侣的男性每日饮酒者的相关风险。