The ARIC-PET Amyloid Imaging Study

ARIC-PET 淀粉样蛋白成像研究

• 批准号: 8545376
• 负责人: Rebecca F Gottesman
• 金额: $ 94.95万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-15 至 2016-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8545376
• 关键词: Address; Age; Aging; Alzheimer' s Disease; American; Amyloid; Amyloid beta-Protein; Amyloid deposition; Ancillary Study; Atherosclerosis; Atrial Fibrillation; Binding; Blood Vessels; Brain; Cerebrovascular Disorders; Cerebrum; Clinical; Cognition; Cognitive; Communities; Country; Data; Dementia; Deposition; Development; Diabetes Mellitus; Diagnosis; Disease; Elderly; Epidemiologic Studies; Evaluation; Funding; Future; Glycosylated hemoglobin A; Half-Life; Hemostatic Agents; Hyperlipidemia; Hypertension; Image; Impaired cognition; In Vitro; Incidence; Indium; Individual; Infarction; Insulin; Label; Life Style; Link; Literature; Magnetic Resonance Imaging; Measures; Memory; Modification; Myocardial Infarction; Neurocognitive; Neurologic; Obesity; Orthostatic Hypotension; Outcome; Participant; Pathogenesis; Pathologic; Pathology; Performance; Peripheral arterial disease; Persons; Pittsburgh Compound-B; Population; Positron-Emission Tomography; Prevalence; Prevention; Prevention strategy; Recruitment Activity; Research; Retinal; Risk; Risk Factors; Risk Marker; Senile Plaques; Site; Smoking; Stroke; Survivors; Techniques; Testing; Thick; Vascular Diseases; aged; amyloid imaging; cerebrovascular; cognitive function; cohort; executive function; follow-up; heart rate variability; in vivo; inflammatory marker; intima media; middle age; mild neurocognitive impairment; prevent; psychosocial; white matter

DESCRIPTION (provided by applicant): With the aging of the U.S. population, the importance of developing preventions and treatments for dementia is increasingly apparent. Evidence suggests that certain vascular risk factors like hypertension, smoking and diabetes, especially when they occur in midlife, may contribute to risk for dementia in late life, and possibly even to Alzheimer's dementia (AD), the most common cause of dementia. Thus, addressing the contributing factors related to vascular disease may be an important element in dementia prevention. What is not well understood is whether vascular risk factors actually cause the changes in the brain that cause AD (specifically, ¿-amyloid plaques) or if having both Alzheimer's and vascular changes in the brain together makes the dementia worse. This study will explore these two hypotheses. The ARIC-PET Amyloid Imaging Study is an ancillary study of the Atherosclerosis Risk in Communities (ARIC) study, a large study involving, at its start 25 years ago, 16,000 individuals representative of 4 diverse U.S. communities. In 2011-2013, as part of the currently funded ARIC Neurocognitive (ARIC-NCS) study, the survivors will undergo neurologic evaluation, cognitive assessment, and, in a subset, brain MRI. We will recruit a further subset, 210 individuals aged 70-90 years from Jackson, MS or Hagerstown, MD with either normal cognition or mild cognitive impairment (MCI), to undergo a PET scan with 18F-AV-45, which is a marker used to identify ¿-amyloid in the brain. In the last 2 years of the study, participants will undergo follow-up cognitive evaluation. The study will determine: 1) whether vascular risk factors and markers, especially from midlife, are associated with increased ¿-amyloid binding, which would indicate that vascular disease directly contributes to AD changes in the brain, or 2) whether ¿-amyloid deposits in the brain in combination with vascular risk factors and markers contribute to cognitive impairments and development of dementia. Study results may help optimize future treatment and prevention trials in individuals with mild cognitive impairment who are at risk for dementia. If strong associations are found between vascular disease and ¿-amyloid plaque deposition, this will provide support for aggressive risk factor treatment as a means to decrease cognitive decline and incidence of dementia.

描述（由申请人提供）：随着美国人口老龄化，开发痴呆症预防和治疗方法的重要性日益明显。有证据表明，某些血管危险因素，如高血压、吸烟和糖尿病，尤其是在中年发生时，可能会增加晚年患痴呆症的风险，甚至可能导致阿尔茨海默氏痴呆（AD），这是痴呆症最常见的原因。因此，解决与血管疾病相关的影响因素可能是预防痴呆症的一个重要因素。目前尚不清楚的是，血管危险因素是否真的导致了导致 AD 的大脑变化（特别是β-淀粉样斑块），或者阿尔茨海默病和大脑血管变化是否共同导致痴呆症恶化。本研究将探讨这两个假设。 ARIC-PET 淀粉样蛋白成像研究是社区动脉粥样硬化风险 (ARIC) 研究的一项辅助研究，该研究于 25 年前开始，涉及代表美国 4 个不同社区的 16,000 名个体。 2011-2013 年，作为目前资助的 ARIC 神经认知 (ARIC-NCS) 研究的一部分，幸存者将接受神经系统评估、认知评估以及脑部 MRI 评估。我们将进一步招募 210 名来自密西西比州杰克逊或马里兰州黑格斯敦、认知正常或轻度认知障碍 (MCI) 的 70-90 岁个体，进行 18F-AV-45 的 PET 扫描，18F-AV-45 是一种用于识别大脑中 β-淀粉样蛋白的标记物。在研究的最后两年，参与者将接受后续认知评估。该研究将确定：1) 血管危险因素和标记物，尤其是中年时期的血管危险因素和标记物，是否与 ¿-淀粉样蛋白结合增加有关，这表明血管疾病直接导致大脑中的 AD 变化，或 2) 大脑中的 ¡-淀粉样蛋白沉积物与血管危险因素和标记物相结合是否会导致认知障碍和痴呆症的发展。研究结果可能有助于优化未来针对有轻度认知障碍且有痴呆风险的个体的治疗和预防试验。如果发现血管疾病和β-淀粉样斑块沉积之间存在很强的关联，这将为积极的危险因素治疗提供支持，作为减少认知能力下降和痴呆发病率的手段。