Pilot 6 - Developmental Exposure Alcohol Research Center

试点 6 - 发育性暴露酒精研究中心

• 批准号: 8381971
• 负责人: JILLA SABETI
• 金额: $ 1.16万
• 依托单位: STATE UNIVERSITY OF NY,BINGHAMTON
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8381971
• 关键词: 4-Aminobutyrate aminotransferase; Adult Children; Alcohol consumption; Alphaxolone; Barbiturates; Behavioral; Benzodiazepines; Biological Assay; Brain; Carboxy-Lyases; Cerebellum; Chloride Ion; Chlorides; Data; Development; Drug Receptors; Ethanol; Exhibits; Exposure to; Fetal Alcohol Exposure; Flurazepam; GABA transporter; Goals; Hippocampus (Brain); Hour; In Vitro; Literature; Mediation; Membrane; Messenger RNA; Modeling; Mothers; Mus; Mutant Strains Mice; Pentobarbital; Pharmaceutical Preparations; Pregnancy; Role; System; Time; Transcript; adolescent offspring; alcohol research; alcohol sensitivity; barbituric acid salt; base; gamma-Aminobutyric Acid; human TFRC protein; hypnotic; mRNA Expression; neurosteroids; postnatal; pregnant; prenatal; prenatal exposure; receptor; receptor expression; receptor function; receptor sensitivity

We have recently taken advantage of a new limited access model of binge-like ethanol intake to expose pregnant C57BL6/J mice to ethanol for 2 hours each day throughout gestation. Daily maternal ethanol intakes of 5-6 g/kg produced a number of behavioral deficits in adult and adolescent offspring. In particular, hypnotic sensitivity to ethanol was reduced at postnatal day (P) 30 and P90 (p<0.01) possibly suggesting that prenatal ethanol exposure alters the normal development GABAA receptor systems. The goals of this proposal are to (1) determine whether maternal DID alters hypnotic and GABAA receptor sensitivity to several drugs with actions at the receptor and (2) to examine the expression of various GABAA receptor subunits in the adolescent and adult offspring of these mice.

我们最近利用了一种新的有限访问模型来暴露酒精摄入