Pilot 4 - Developmental Exposure Alcohol Research Center

最近的数据表明，K阿片系统在婴儿期对乙醇的接受和强化中起作用， 成年K阿片受体的药理学阻断增强了乙醇摄入和强化特性 在成年啮齿类动物中，K受体的内源性活性对于婴儿发现乙醇食欲至关重要。 此外，K阿片系统的激活对于成年大鼠是令人厌恶的。相比之下，在幼年大鼠中，中央 这个系统的激活是非常强化的。本提案将检验K阿片样物质 系统切换从调解食欲厌恶性质的乙醇之间的第一和第二 出生后一周，这种个体发生开关发生时，K阿片激活的动机属性 变得令人厌恶，而不是令人有食欲。最后，中枢乙醇后K阿片系统的变化 将在出生后的前两周期间评估施用。

Recent data implicate the K opioid system in ethanol acceptance and reinforcement during infancy and adulthood. Pharmacological blockade of K opioid receptors enhances ethanol intake and reinforcing properties in adult rodents, whereas endogenous activity at K receptors is essential for infants to find ethanol appetitive. Furthermore, activation of the K opioid system is aversive for adult rats. In contrast, in infant rats, central activation of this system is extremely reinforcing. The present proposal will test the hypothesis that the K opioid system switches from mediating appetitive to aversive properties of ethanol between the first and the second postnatal week and that this ontogenetic switch occurs when motivational properties of K opioid activation become aversive instead of appetitive. Finally, changes in the K opioid system following central ethanol administration will be assessed during the first two weeks of postnatal life.