Animal Models Core Facility

动物模型核心设施 我们正在将之前处理老鼠癌症节点的两个核心合并为一个单独的动物IVIodeis核心，其功能是帮助LCCC成员进行与老鼠相关的所有方面的研究。核心员工协助动物处理、异种肿瘤模型、群体管理、治疗试验、成像研究、等位基因表型以及基因工程小鼠(GEM)的设计和生产。此核心增加了 癌症中心通过实现经济高效的小鼠测试，即使是那些在动物工作方面没有重要基础设施和专业知识的成员也可以进行。《核心》由夏琳·罗斯和戴尔·考利共同执导，教职员工联合顾问诺曼·夏普莱斯和伯纳德·魏斯曼担任。自上一个周期以来，夏普莱斯博士和考利博士加入了领导层，以增加宝石模型方面的专业知识，并扩大核心能力。实验帮助范围从转基因/基因敲除等位基因的生产和设计到等位基因表型、动物成像和新型抗癌药物在异种移植和基因工程肿瘤模型中的治疗测试。核心网站有39个用户(97%的用户是经过同行评审的动物研究成员)。去年，核心的动物研究部分出现了显著增长，自2009年8月以来，核心工作人员的工作超出了总体能力。我们要求增加预算 其中283,591美元将占动物模型核心预算总额的15%，以促进扩大使用。 动物模型核心在下一个周期将显著增长，主要是由于NIH增加了对北卡罗来纳大学研究人员的资金，校园动物空间增加了50%，以及以癌症遗传学和临床前治疗测试为特色的战略计划。基因医学大楼最近开放，可以容纳40,000多个笼子。影像研究大楼将于2013年开放，届时将再增加2,000人 笼子的纵向老鼠治疗和成像协议。动物模型中心处于有利地位，可以成为癌症中心成员的纽带，利用宝石和异种移植肿瘤模型的力量进行基础和转化性癌症研究。

Animal Models Core Facility We are combining two previous cores dealing with mouse cancer nnodels into a single Animal IVIodeis Core that functions to help LCCC members with all aspects of mouse-related research. Core staff assists with animal handling, xenograft tumor models, colony management, therapeutic trials, imaging studies, allele phenotyping and the design and production of genetically engineered mice (GEM). This core adds value to the Cancer Center by enabling cost-efficient murine testing even by members who do not have significant infrastructure and expertise for animal work. The core is co-directed by Chariene Ross and Dale Cowley, with faculty co-advisors Norman Sharpless and Bernard Weissman. Dr. Sharpless and Dr. Cowley have been added to the leadership since the last cycle to add expertise in GEM models and expand core capabilities. Experimental help spans the spectrum from transgenic / knockout allele production and design to allele phenotyping, animal imaging and therapeutic testing of novel anti-cancer agents in xenograft and genetically engineered tumor models. The core has 39 users (97% use by peer reviewed members for Animal Studies). Significant growth has occurred in the animal studies component of the core during the last year with core staff operating beyond overall capacity since August 2009. We request an increased budget of $283,591 that will represent 15% of the total Animal Models Core budget to promote expanded use. The Animal Models Core will grow significantly during the next cycle, driven largely by increased NIH funding to UNC investigators, the 50% increase in campus animal space and a strategic plan featuring cancer genetics and preclinical therapeutics testing. The Genetic Medicine building has recently opened with space for over 40,000 additional cages. The Imaging Research Building will open in 2013 with 2,000 additional cages for longitudinal mouse therapy and Imaging protocols. The Animal Models Core is well positioned to become the nexus for Cancer Center members exploiting the power of GEMs and xenograft tumor models for basic and translational cancer research.