Center for Critical Assessment of Structure Prediciton

结构预测批判评估中心

• 批准号: 8484848
• 负责人: KRZYSZTOF A FIDELIS
• 金额: $ 50.71万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-06-15 至 2016-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8484848
• 关键词: Academia; Address; Amino Acid Sequence; Area; Beds; Biochemical Pathway; Biological Process; Biology; California; Categories; Collection; Communities; Computational Biology; Computer Simulation; Computer software; Crystallography; Data; Databases; Development; Disease; Drug Design; Educational Curriculum; Educational process of instructing; Effectiveness; Evaluation; Goals; Human; Individual; Investigation; Knowledge; Laboratories; Medicine; Membrane Proteins; Methodology; Methods; Modeling; Molecular Structure; Monitor; NMR Spectroscopy; Peptide Sequence Determination; Performance; Physics; Play; Process; Proteins; Publications; RNA; Relative (related person); Research; Research Infrastructure; Research Personnel; Resources; Rest; Role; Running; Seasons; Source; Staging; Stream; Structure; Students; System; Techniques; Testing; Text; Time; Universities; Work; abstracting; base; experience; human disease; insight; interest; macromolecule; meetings; method development; operation; programs; protein structure; public health relevance; research study; teacher; tool; web site

Enter the text here that is the new abstract information for your application. This section must be no longer than 30 lines of text. Project Summary (no changes): The primary goal of this project is to provide the infrastructure for the Critical Assessment of Structure Prediction (CASP) program, dedicated to the objective evaluation of macromolecular structure modeling methods. Extensive knowledge of protein and RNA structures will significantly aid the investigation of macromolecular function, interactions, and biochemical pathways. It will also have a major impact on the understanding of biology and human disease, and eventually on drug design. Experimental determination of structure is inherently time-consuming and costly. For macromolecules that have not been addressed by experiment, a computational modeling approach often provides an alternative. Modeling methods, however, are continually evolving and vary in their effectiveness. The CASP process was established to answer two main questions: First, what level of modeling quality can be expected of these techniques? And second, which methods offer the most promise for continued development? CASP is a community-wide program, with over 200 research groups world-wide submitting over 85,000 predictions in the last round. Our group is the primary infrastructure resource for CASP, and handles processing of predictions, develops and implements evaluation software, performs prediction assessment, develops analysis and display tools, and facilitates access to predictions and their evaluation data. We propose to support the current biennial operation of CASP and to expand it by the addition of assessments performed on a continuing basis. To increase the supply of interesting modeling targets we will systematically broaden the network of collaborating crystallography and NMR spectroscopy research groups, including new centers dedicated to the determination of structure of membrane proteins. The expanded network will also be capable of providing the still rare RNA structures, allowing extension of CASP to the assessment of RNA structure modeling. To help overcome the most significant obstacles to progress in structure prediction, we will add a class of specialized assessments focused on specific stages of the modeling process, providing a means of evaluating the performance of these individual steps. Finally, we will place special emphasis on interactions with teachers and researchers throughout academia, with the goal of disseminating the insights and wealth of data gained through CASP.

在此输入文本，它是您的应用程序的新摘要信息。此部分必须为no 超过30行的文本。 项目摘要(无更改)： 该项目的主要目标是为结构的关键评估提供基础设施 预测(CASP)程序，致力于对大分子结构建模进行客观评估 方法：研究方法。对蛋白质和RNA结构的广泛了解将大大有助于对 大分子功能、相互作用和生化途径。它还将对 对生物学和人类疾病的理解，以及最终对药物设计的理解。实验 确定结构本身就是费时费钱的。对于还没有的大分子 通过实验解决，计算建模方法通常提供了另一种选择。 然而，建模方法在不断发展，其有效性也在不断变化。CASP进程 主要回答了两个问题：第一，可以期望什么样的建模质量 这些技巧？第二，哪些方法为持续发展提供了最大希望？ CASP是一个社区范围的计划，全世界有200多个研究小组提交了超过85,000份报告 最后一轮的预测。我们的团队是CASP的主要基础设施资源，并处理 处理预测，开发和实施评估软件，执行预测 评估、开发分析和显示工具，并促进访问预测及其 评估数据。我们建议支持履约协助方案目前的两年期运作，并将其扩大到 增加持续进行的评估。增加趣味造型的供给 我们将系统地扩大结晶学和核磁共振的合作网络 光谱学研究小组，包括致力于确定结构的新中心 膜蛋白。扩展后的网络还将能够提供仍然稀有的RNA 结构，允许将CASP扩展到RNA结构建模的评估。帮助克服 最大的障碍是结构预测的进展，我们将增加一类专门的 评估侧重于建模过程的特定阶段，提供了一种评估 这些单独步骤的执行。最后，我们将特别强调与 整个学术界的教师和研究人员，目标是传播洞察力和财富 通过履约协助方案获得的数据。