Critical Assessment of Structure Prediction Workshops

结构预测批判性评估研讨会

• 批准号: 8785982
• 负责人: KRZYSZTOF A FIDELIS
• 金额: $ 2.81万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-01 至 2015-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8785982
• 关键词: Address; Area; Back; Biochemical Pathway; Biological; Biological Process; Biology; Categories; Collaborations; Communities; Computer Simulation; Country; DNA; Development; Disadvantaged; Disease; Drug Design; Educational workshop; Ensure; Equilibrium; Evaluation; Evaluation Methodology; Goals; Imagery; Individual; Investigation; Journals; Knowledge; Lead; Medicine; Methods; Modeling; Molecular Structure; Monitor; Performance; Play; Process; Property; Proteins; Publishing; Research; Rest; Role; Science; Scientist; Sequence Determination; Series; Solutions; Structure; Techniques; Testing; Time; base; blind; design; experience; genome-wide; human disease; information model; insight; interest; meetings; novel; programs; protein folding; protein structure; protein structure prediction; public health relevance; research study; success; symposium; tool; web site

DESCRIPTION (provided by applicant): The purpose of the CASP experiments and workshops is to provide independent assessment of macromolecular structure modeling methods. With the success of genome-wide sequencing, determination of the corresponding DNA-encoded structures becomes increasingly important. Extensive knowledge of protein structures will significantly aid the investigation of macromolecular function, interactions, and biochemical pathways. It will also have a major impact on the understanding of biology and human disease, and eventually on drug design. In spite of substantial progress, experimental determination of structure remains inherently time-consuming and costly, and has provided coverage of less than 1% of the known sequences. Computational modeling techniques provide coverage of a much higher fraction of sequences, albeit at lower accuracy. The primary goals of CASP are to establish the capabilities and limitations of current methods of modeling structure from sequence, to determine where progress is being made, and where the field is held back by specific bottlenecks. Methods are assessed on the basis of the analysis of a large number of blind predictions of protein structure. These goals are achieved through a series of large-scale community experiments, conducted every two years, and accompanying workshops. The experiments involve well over 100 research groups from more than 20 countries. In each experiment, two preliminary workshops are concerned with planning and monitoring the experiment. The main workshop brings together the community of participating scientists for an intensive discussion and analysis of the results of the experiment. An additional goal of these workshops is to provide an opportunity to junior scholars and newcomers to the field to familiarize themselves with the most pertinent and most current issues in this area of science. The CASP workshops are not a typical conference but a culmination of the community experiment. Support is requested for the workshop component of the 11th, 12th and 13th CASP experiments.

描述（由申请人提供）：CASP实验和研讨会的目的是提供大分子结构建模方法的独立评估。随着全基因组测序的成功，确定相应的DNA编码结构变得越来越重要。蛋白质结构的广泛知识将大大有助于大分子功能，相互作用和生物化学途径的研究。它也将对生物学和人类疾病的理解产生重大影响，并最终影响药物设计。尽管取得了实质性进展，但结构的实验测定仍然固有地耗时且昂贵，并且提供了不到1%的已知序列的覆盖率。计算建模技术提供了高得多的序列分数的覆盖率，尽管准确度较低。CASP的主要目标是建立从序列建模结构的当前方法的能力和局限性，以确定正在取得进展的地方，以及该领域被特定瓶颈阻碍的地方。方法进行评估的基础上分析了大量的蛋白质结构的盲目预测。这些目标是通过每两年进行一次的一系列大规模社区实验和相应的讲习班来实现的。这些实验涉及来自20多个国家的100多个研究小组。在每项试验中，两个初步讲习班负责规划和监测试验。主要研讨会将与会科学家聚集在一起，对实验结果进行深入讨论和分析。这些讲习班的另一个目标是为初级学者和该领域的新来者提供一个机会，使他们熟悉这一科学领域最相关和最新的问题。CASP研讨会不是一个典型的会议，而是社区实验的高潮。要求为第11、12和13次CASP实验的讲习班部分提供支助。