Center for Critical Assessment of Structure Prediciton

在此输入文本，它是应用程序的新摘要信息。本节必须是否 超过30行的文本。 项目摘要（无变更）： 该项目的主要目标是为结构的关键评估提供基础设施 预测（CASP）程序，致力于大分子结构建模的客观评估 方法.对蛋白质和RNA结构的广泛了解将大大有助于研究 大分子功能、相互作用和生化途径。这也将对 对生物学和人类疾病的理解，最终对药物设计的理解。实验 结构的确定固有地是耗时和昂贵的。对于那些没有 通过实验解决了这个问题，计算建模方法通常提供了一种替代方案。 然而，建模方法在不断发展，其有效性也各不相同。CASP进程 建立模型是为了回答两个主要问题：第一，什么水平的建模质量可以预期的 这些技术？第二，哪些方法最有可能实现持续发展？ CASP是一个社区范围的计划，全球有200多个研究小组提交了85，000多份 最后一轮的预测。我们的团队是CASP的主要基础架构资源， 处理预测，开发和实施评估软件，进行预测 评估，开发分析和显示工具，并促进访问预测及其 评价数据我们建议支持社区支援计划现时每两年一次的运作，并在 增加持续进行的评估。为了增加有趣的模特的供应 目标，我们将系统地拓宽合作晶体学和核磁共振网络 光谱研究小组，包括新的中心，致力于确定结构的 膜蛋白扩展后的网络也将能够提供仍然罕见的RNA 结构，允许CASP扩展到RNA结构建模的评估。来帮助克服 最重要的障碍，在结构预测的进展，我们将增加一类专门的 评估侧重于建模过程的特定阶段，提供了一种评估 执行这些单独的步骤。最后，我们将特别强调与 教师和研究人员在整个学术界，与传播的见解和财富的目标 通过CASP获得的数据。

Enter the text here that is the new abstract information for your application. This section must be no longer than 30 lines of text. Project Summary (no changes): The primary goal of this project is to provide the infrastructure for the Critical Assessment of Structure Prediction (CASP) program, dedicated to the objective evaluation of macromolecular structure modeling methods. Extensive knowledge of protein and RNA structures will significantly aid the investigation of macromolecular function, interactions, and biochemical pathways. It will also have a major impact on the understanding of biology and human disease, and eventually on drug design. Experimental determination of structure is inherently time-consuming and costly. For macromolecules that have not been addressed by experiment, a computational modeling approach often provides an alternative. Modeling methods, however, are continually evolving and vary in their effectiveness. The CASP process was established to answer two main questions: First, what level of modeling quality can be expected of these techniques? And second, which methods offer the most promise for continued development? CASP is a community-wide program, with over 200 research groups world-wide submitting over 85,000 predictions in the last round. Our group is the primary infrastructure resource for CASP, and handles processing of predictions, develops and implements evaluation software, performs prediction assessment, develops analysis and display tools, and facilitates access to predictions and their evaluation data. We propose to support the current biennial operation of CASP and to expand it by the addition of assessments performed on a continuing basis. To increase the supply of interesting modeling targets we will systematically broaden the network of collaborating crystallography and NMR spectroscopy research groups, including new centers dedicated to the determination of structure of membrane proteins. The expanded network will also be capable of providing the still rare RNA structures, allowing extension of CASP to the assessment of RNA structure modeling. To help overcome the most significant obstacles to progress in structure prediction, we will add a class of specialized assessments focused on specific stages of the modeling process, providing a means of evaluating the performance of these individual steps. Finally, we will place special emphasis on interactions with teachers and researchers throughout academia, with the goal of disseminating the insights and wealth of data gained through CASP.