Neurobehavioral & emotional deficits in male & female alcoholics

描述(由申请人提供)：如PA-11-047(药物和酒精滥用/依赖中的女性和性别/性别差异)所述，药物使用障碍(SODS)的病因、进展和后果方面的性别差异仍未完全了解。目前的提案侧重于这一差距的一个重要方面：后果。更具体地说，它旨在澄清男性和女性如何不同地体验酒精依赖的神经行为后果。值得注意的是，大多数针对神经行为评估的研究都集中在传统上定义的神经认知/神经心理领域。神经行为的另一个受损部分和成功适应的一个关键方面，情绪处理，主要在另一篇文献中进行了研究。为了更好地了解神经行为妥协的广度，需要同时评估男性和女性的神经认知和情绪表现。此外，尽管对社区样本的研究通常显示女性在这些任务上具有优势，但酗酒者之间的性别差异很少被提及。为了加强解释和指导未来的研究，这项工作必须从概念上加以驱动。针对这些问题，我们建议在足够多的男性和女性戒酒者(n=100，50女性)和社区对照(n=100，50女性)样本中评估认知和情绪功能，以解决主要和相互作用的影响。指导这项工作的是一个概念模型，它指导可测试的假说，从而为未来的研究提供信息，并提供与酒精相关的神经行为(即认知和情绪)损害的潜在过程的临床相关信息。

DESCRIPTION (provided by applicant): As detailed in PA-11-047 (Women and sex/gender differences in drug and alcohol abuse/dependence), gender differences in the etiology, progression, and consequences of substance use disorders (SUDs) remain incompletely understood. The current proposal focuses on one important aspect of this gap; consequences. More specifically, it is directed to clarifying how men and women may differentially experience the neurobehavioral consequences of alcohol dependence. It is noteworthy that most research directed to neurobehavioral assessments has focused on traditionally defined neurocognitive/ neuropsychological domains. Another compromised component of neurobehavior and a key aspect of successful adaptation, emotional processing, has been examined primarily in a separate literature. To better understand the breadth of neurobehavioral compromise, concurrently assessing neurocognitive and emotional performance in men and women is required. Furthermore, although studies of community samples typically reveal a female advantage on these tasks, gender differences among alcoholics are infrequently addressed. To enhance interpretation and direct future research, it is imperative that this work be conceptually driven. In response to these issues, we propose to assess cognitive and emotional functions in sufficient samples of male and female detoxified alcoholics (n=100, 50 females) and community controls (n=100, 50 females) to address both main and interaction effects. Guiding this work is a conceptual model which directs testable hypotheses, thereby informing future research and providing clinically relevant information concerning the processes underlying alcohol-related neurobehavioral (i.e., cognitive and emotional) impairment.