Pilot Component

斯克里普斯研究所酒精研究中心(TSRI-ARC)的试点部分将提供 进行先导研究以推进TSRI-ARC神经适应研究议程的方案 与从酗酒到依赖的转变相关的机制，并可能产生 与整个中心的重点相关的独立赠款申请。试行的主要目标是 项目计划使TSRI-ARC能够探索与以下相关的创新研究的新方向 中心的目标(具体目标1)，并招募酒精研究领域的新科学家，从而 使中心调查人员接触到新的视角和方法(具体目标2)。总的来说，这是意料之中的 试点项目将向合格的调查人员提供种子资金，使他们能够收集足够的资金 通过R01、R21、KO1或类似方法测试新假说的初步数据 机制(或消除一个不值得研究的新假说)。最终，试点研究的目的是 为TSRI-ARC提供开发和探索新的研究活动的灵活手段 或方向和独特的科学机会，有可能演变为独立资助的 研究项目。拟议的试点研究被整合到整个TSRI-ARC方案中，涉及 创新方法，这将对研究组成部分产生翻译影响。重点是 在头两年，被安排在研究将开发创新的新的令人兴奋的神经生物学 神经回路靶点的研究方法和神经适应的人体翻译研究 与过度饮酒和依赖有关。正如我们前一次试验的成功所证明的那样 计划，我们预计试点的结果将有助于启动创新的研究和在 在酒精中毒的神经生物学研究方面的平行新职业。

The Pilot Component The Scripps Research Institute Alcohol Research Center- (TSRI-ARC) will provide a program for conducting pilot studies that advance the research agenda of the TSRI-ARC on neuroadaptive mechanisms associated with the transition from binge drinking to dependence and potentially generate independent grant applications relevant to the focus of the Center at Large. The principal goals of the Pilot Project Program are to enable the TSRI-ARC to explore new directions for innovative research related to the center's goals (Specific Aim 1) and to recruit scientists new to alcohol research into the field, thereby exposing center investigators to fresh perspectives and methods (Specific Aim 2). In general, it is expected that the Pilot projects will provide seed funding to qualified investigators to enable them to gather sufficient preliminary data to attract support for testing a new hypothesis through R01, R21, KO1 or similar mechanisms (or to eliminate a new hypothesis as not worth pursuing). Ultimately the aim of the Pilot Studies component is to provide the TSRI-ARC with a flexible means to develop and explore new research activities or directions and unique scientific opportunities that have the potential to evolve into independently-funded research projects. The proposed pilot studies are integrated into the overall TSRI-ARC program and involve innovative approaches, which will have translational impact across the research components. Emphasis has been placed, in the first two years, on studies that will develop innovative new exciting neurobiological approaches to neurocircuitry targets and on human translational studies for the neuroadapatations associated with excessive drinking and dependence. As demonstrated with the success of our previous Pilot programs, we anticipate that the results of the pilots will help launch innovative lines of research and in parallel new careers in the study of the neurobiology of alcoholism.