Pilot Component

试点组件

• 批准号: 8401638
• 负责人: George F. Koob
• 金额: $ 10.23万
• 依托单位: SCRIPPS RESEARCH INSTITUTE, THE
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-02-10 至 2017-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8401638
• 关键词: Alcoholism; Applications Grants; Cellular Neurobiology; Data; Dependence; Funding; Goals; Heavy Drinking; Human; Methods; Neurobiology; Pilot Projects; Qualifying; Recruitment Activity; Research; Research Activity; Research Institute; Research Personnel; Research Project Grants; Scientist; Seeds; Testing; alcohol effect; alcohol research; binge drinking; career; flexibility; innovation; programs; success; translational study

The Pilot Component The Scripps Research Institute Alcohol Research Center- (TSRI-ARC) will provide a program for conducting pilot studies that advance the research agenda of the TSRI-ARC on neuroadaptive mechanisms associated with the transition from binge drinking to dependence and potentially generate independent grant applications relevant to the focus of the Center at Large. The principal goals of the Pilot Project Program are to enable the TSRI-ARC to explore new directions for innovative research related to the center's goals (Specific Aim 1) and to recruit scientists new to alcohol research into the field, thereby exposing center investigators to fresh perspectives and methods (Specific Aim 2). In general, it is expected that the Pilot projects will provide seed funding to qualified investigators to enable them to gather sufficient preliminary data to attract support for testing a new hypothesis through R01, R21, KO1 or similar mechanisms (or to eliminate a new hypothesis as not worth pursuing). Ultimately the aim of the Pilot Studies component is to provide the TSRI-ARC with a flexible means to develop and explore new research activities or directions and unique scientific opportunities that have the potential to evolve into independently-funded research projects. The proposed pilot studies are integrated into the overall TSRI-ARC program and involve innovative approaches, which will have translational impact across the research components. Emphasis has been placed, in the first two years, on studies that will develop innovative new exciting neurobiological approaches to neurocircuitry targets and on human translational studies for the neuroadapatations associated with excessive drinking and dependence. As demonstrated with the success of our previous Pilot programs, we anticipate that the results of the pilots will help launch innovative lines of research and in parallel new careers in the study of the neurobiology of alcoholism.

试点部分斯克里普斯研究所酒精研究中心 (TSRI-ARC) 将提供 进行试点研究的计划，以推进 TSRI-ARC 关于神经适应性的研究议程 与从酗酒到依赖的转变相关的机制，并可能产生 与一般中心的重点相关的独立拨款申请。试点的主要目标 项目计划旨在使 TSRI-ARC 能够探索与以下领域相关的创新研究的新方向： 中心的目标（具体目标 1）并招募刚接触酒精研究的科学家进入该领域，从而 让中心研究人员接触新的观点和方法（具体目标 2）。总的来说，预计 试点项目将为合格的研究人员提供种子资金，使他们能够收集足够的资金 通过 R01、R21、KO1 或类似方法获得测试新假设的支持的初步数据 机制（或消除不值得追求的新假设）。试点研究的最终目标 组成部分是为 TSRI-ARC 提供灵活的方式来开发和探索新的研究活动 或有潜力发展为独立资助的方向和独特的科学机会 研究项目。拟议的试点研究已纳入整个 TSRI-ARC 计划并涉及 创新方法，这将对整个研究组成部分产生转化影响。强调有 在头两年内，我们进行了开发创新的、令人兴奋的神经生物学研究 神经回路目标的方法和神经适应的人类转化研究 与过度饮酒和依赖性有关。正如我们之前试点的成功所证明的那样 计划，我们预计试点的结果将有助于启动创新的研究路线，并在 与酗酒神经生物学研究并行的新事业。