Component 11: Pilot

试点项目部分将为开发和探索新的研究提供灵活的手段 TSRI-ARC的活动或方向，可以演变为独立资助的研究项目。 在拟议供资期间的第1至第5年，试点项目部分计划资助8个不同的项目 项目(6 x 2年、2 x 1年)。这些项目中开展的工作将为TSRI-ARC提供新的方向 开发成功的联邦拨款申请，并吸引了几名新的研究人员到我们的中心。 中心主任乔治·F·库布博士将负责这一部分，弗里德伯特·韦斯博士将负责这一部分 TSRI-ARC的成员将共同管理这一部分。试验计划的申请将向 所有TSRI-ARC附属调查人员和中心内的其他调查人员。每项提案都将是 由中心至少两名成员评估科学价值/创新和其他几项标准 外部科学咨询委员会和中心主任或联席主任。对资金的建议将 由中心执行委员会审议批准。我们建议在第一年推行四项试验计划： 2名飞行员，3-4年2名飞行员，第5年2名飞行员。飞行员1(首席调查员，Pietro Sanna，医学博士)是 旨在探讨蛋白激酶抑制因子α系统在暴饮暴食过程中的作用。 TSRI-ARC动物模型对大鼠的依赖。Pilot 2(首席调查员Michael Taffe， 博士学位)旨在探索在非人类灵长类动物模型(恒河猴)中狂饮的动物模型 猴子)，以及在这个模型中酗酒可能的神经药理效应。。领航员3(校长 约翰·波里奇博士，研究员)旨在探索一种适合低饮酒者和高饮酒者的神经电表型 将以年轻人为特征，并将提供有关神经系统变化的关键信息 与年轻人大量饮酒有关的加工。飞行员4(首席调查员，辛迪 埃勒斯博士)旨在比较对酒精的主观反应和低水平和低水平的遗传差异 对特定种族背景(东印度和非洲)的年轻成年人酗酒者的研究 起源)在特立尼达。选定在第1-2年资助的试点项目将把新的调查人员引入 TSRI-ARC，预计将通过扩大对以下方面的研究来丰富中心的整体研究工作 过度饮酒神经回路中酒精神经适应的分子机制 在从酗酒到依赖的过渡过程中饮酒。此外，试点项目还包括 被鼓励帮助弥合临床前研究和临床研究之间的差距。

The Pilot Project Component will provide a flexible means for developeing and exploring new research activities or directions for the TSRI-ARC, that can evolve into independently funded research projects. During Years 1-5 of the proposed funding period, the Pilot Project Component is planning to fund 8 different projects ( 6 x 2 yrs, 2 x 1 yr). Work conducted in these projects will provide new directions for the TSRI-ARC in developing successful federal grant applications, and in attracting several new investigators to our Center. Dr. George F. Koob, the Center Director will manage this Component and Dr. Friedbert Weiss, a senior member of the TSRI-ARC, will co-manage this Component. Pilot Project applications will be solicited from all TSRI-ARC affiliated investigators and to other investigators in the Center at Large. Each proposal will be evaluated for scientific merit/innovation and several other criteria by at least two members of the Center's External Scientific Advisory Board and the Center Director or Co-Director. Recommendations for funding will be considered for approval by the Center Executive Committee. Four Pilot Projects are proposed for Year 1- 2, 2 pilots for Years 3-4 and 2 pilots for Year 5. Pilot 1 (Principal Investigator, Pietro Sanna, M.D.), is designed to explore the role of the protein kinase inhibitor alpha system during the course of bingeing and dependence in rats using the animal models of the TSRI-ARC. Pilot 2 (Principal Investigator, Michael Taffe, Ph.D.) is designed to explore an animal model of binge drinking in a nonhuman primate model (rhesus monkeys) and possible neuropharmacological effects of binge drinking in this model. . Pilot 3 (Principal Investigator, John Polich, Ph. D.) is designed to explore a neuroelectric phenotype for low and high drinkers will be characterized in young adults and will provide key information about changes in nervous system processing associated with heavy alcohol consumption in young adults. Pilot 4 (Principal Investigator, Cindy Ehlers, Ph. D.) is designed to compare subjective responses to ethanol and genetic differences in low and high drinkers study of young adult binge drinkers of a unique ethnic background (East Indian and African origin) in Trinidad. Pilot Projects selected for funding during Years 1-2 will bring new investigators to the TSRI-ARC and are expected to enrich the Center's overall research effort by extending the study of molecular mechanisms underlying ethanol neuroadaptation in the neurocircuits responsible for excessive drinking of ethanol during the transition from binge drinking to dependence. In addition, Pilot Projects have been encouraged to help bridge the gap between the preclinical and clinical studies.