Component 11: Pilot

第 11 部分：试点

• 批准号: 7497311
• 负责人: George F. Koob
• 金额: $ 30.09万
• 依托单位: SCRIPPS RESEARCH INSTITUTE, THE
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-25 至 2012-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7497311
• 关键词: African; Alcohol consumption; Animal Model; Applications Grants; Clinical Research; Consensus; Data; Dependence; Descriptor; Doctor of Medicine; Doctor of Philosophy; East Indian; Ethanol; Evaluation; Funding; Future; Genetic; Goals; Heavy Drinking; Lead; Macaca mulatta; Methods; Modeling; Molecular; Nervous system structure; Occupational activity of managing finances; Phenotype; Pilot Projects; Principal Investigator; Process; Progress Reports; Protein Kinase Inhibitors; Qualifying; Rate; Rattus; Recommendation; Recruitment Activity; Research; Research Activity; Research Personnel; Research Project Grants; Rest; Role; Scientific Evaluation; Scientist; Seeds; System; Time; Trinidad; United States National Institutes of Health; Update; Work; Writing; alcohol research; alcohol response; binge drinker; binge drinking; design; innovation; member; neuroadaptation; nonhuman primate; pre-clinical; programs; protein kinase inhibitor; young adult

The Pilot Project Component will provide a flexible means for developeing and exploring new research activities or directions for the TSRI-ARC, that can evolve into independently funded research projects. During Years 1-5 of the proposed funding period, the Pilot Project Component is planning to fund 8 different projects ( 6 x 2 yrs, 2 x 1 yr). Work conducted in these projects will provide new directions for the TSRI-ARC in developing successful federal grant applications, and in attracting several new investigators to our Center. Dr. George F. Koob, the Center Director will manage this Component and Dr. Friedbert Weiss, a senior member of the TSRI-ARC, will co-manage this Component. Pilot Project applications will be solicited from all TSRI-ARC affiliated investigators and to other investigators in the Center at Large. Each proposal will be evaluated for scientific merit/innovation and several other criteria by at least two members of the Center's External Scientific Advisory Board and the Center Director or Co-Director. Recommendations for funding will be considered for approval by the Center Executive Committee. Four Pilot Projects are proposed for Year 1- 2, 2 pilots for Years 3-4 and 2 pilots for Year 5. Pilot 1 (Principal Investigator, Pietro Sanna, M.D.), is designed to explore the role of the protein kinase inhibitor alpha system during the course of bingeing and dependence in rats using the animal models of the TSRI-ARC. Pilot 2 (Principal Investigator, Michael Taffe, Ph.D.) is designed to explore an animal model of binge drinking in a nonhuman primate model (rhesus monkeys) and possible neuropharmacological effects of binge drinking in this model. . Pilot 3 (Principal Investigator, John Polich, Ph. D.) is designed to explore a neuroelectric phenotype for low and high drinkers will be characterized in young adults and will provide key information about changes in nervous system processing associated with heavy alcohol consumption in young adults. Pilot 4 (Principal Investigator, Cindy Ehlers, Ph. D.) is designed to compare subjective responses to ethanol and genetic differences in low and high drinkers study of young adult binge drinkers of a unique ethnic background (East Indian and African origin) in Trinidad. Pilot Projects selected for funding during Years 1-2 will bring new investigators to the TSRI-ARC and are expected to enrich the Center's overall research effort by extending the study of molecular mechanisms underlying ethanol neuroadaptation in the neurocircuits responsible for excessive drinking of ethanol during the transition from binge drinking to dependence. In addition, Pilot Projects have been encouraged to help bridge the gap between the preclinical and clinical studies.

试点项目部分将为开发和探索新研究提供灵活的手段 TSRI-ARC 的活动或方向，可以发展为独立资助的研究项目。 在拟议资助期的第 1-5 年，试点项目部分计划资助 8 个不同的项目 项目（6 x 2 年、2 x 1 年）。这些项目中进行的工作将为 TSRI-ARC 提供新的方向 开发成功的联邦拨款申请，并吸引几位新的研究人员到我们中心。 中心主任 George F. Koob 博士将管理该部分，高级研究员 Friedbert Weiss 博士将负责管理该部分。 TSRI-ARC 成员将共同管理该组件。试点项目申请将由 所有 TSRI-ARC 附属调查员以及普通中心的其他调查员。每项提案都将 由至少两名中心成员评估科学价值/创新和其他几项标准 外部科学顾问委员会和中心主任或联合主任。资金建议将 报中心执行委员会审议批准。建议第一年开展四个试点项目 - 2、第 3-4 年有 2 个试点，第 5 年有 2 个试点。试点 1（首席研究员，Pietro Sanna，医学博士）是 旨在探索蛋白激酶抑制剂α系统在暴饮暴食过程中的作用 使用 TSRI-ARC 动物模型对大鼠进行依赖性。飞行员 2（首席研究员 Michael Taffe， Ph.D.）旨在探索非人类灵长类动物模型（恒河猴）中酗酒的动物模型 猴子）以及该模型中酗酒可能产生的神经药理学效应。 。试点 3（校长 研究员 John Polich 博士）旨在探索低饮酒者和高饮酒者的神经电表型 将以年轻人为特征，并提供有关神经系统变化的关键信息 与年轻人大量饮酒有关的加工。试点 4（首席研究员，Cindy Ehlers 博士）旨在比较低水平和低水平人群对乙醇的主观反应和遗传差异。 对具有独特种族背景（东印度和非洲）的年轻成人酗酒者的研究 原产地）在特立尼达。在第一年至第二年期间选择资助的试点项目将为新的研究人员带来新的研究人员 TSRI-ARC 预计将通过扩展以下领域的研究来丰富该中心的整体研究工作： 神经回路中乙醇神经适应的分子机制负责过量 从酗酒到依赖的过渡期间饮用乙醇。此外，试点项目还 鼓励帮助弥合临床前研究和临床研究之间的差距。