Component 11: Pilot

试点项目部分将为开发和探索新的研究提供灵活的手段 TSRI-ARC的活动或方向，可以演变为独立资助的研究项目。 在拟议供资期的第1-5年，试点项目部分计划为8个不同的项目提供资金， 项目（6x 2年，2x 1年）。这些项目的工作将为TSRI-ARC提供新的方向 在开发成功的联邦拨款申请，并在吸引几个新的研究人员到我们的中心。 博士乔治F. Koob，中心主任将管理该组件和Friedbert韦斯博士，一个高级 TSRI-ARC成员将共同管理该组件。试验计划的申请将由 所有TSRI-ARC附属研究者和中心的其他研究者。每项提案将 至少由中心的两名成员评估科学价值/创新和其他几个标准 外部科学顾问委员会和中心主任或联合主任。供资建议将 由中心执行委员会审议批准。第一年拟进行四项试验计划- 2，3-4年级2名试点，5年级2名试点。试点1（主要研究者，Pietro Sanna，M.D.），是 旨在探索蛋白激酶抑制剂α系统在暴食过程中的作用， 使用TSRI-ARC的动物模型在大鼠中测定依赖性。试点2（主要研究者，Michael Taffe， 博士）在非人灵长类动物模型（恒河猴）中探索一种狂欢饮酒的动物模型 猴子）和在该模型中狂饮的可能神经药理学作用。.试点3（主要 研究员，John Polich博士）旨在探索低和高饮酒者的神经电表型 将在年轻人中进行表征，并将提供有关神经系统变化的关键信息 与年轻人大量饮酒有关的加工过程。试点4（主要研究者，Cindy 埃勒斯博士）目的是比较主观反应，乙醇和遗传差异，在低， 一项针对具有独特种族背景（东印度和非洲）的年轻成年狂饮者的研究 在Trinidad。在第1-2年期间选定的供资试点项目将吸引新的研究人员到 TSRI-ARC，预计将通过扩展对以下问题的研究来丰富该中心的整体研究工作： 神经回路中乙醇神经适应的分子机制 在从酗酒到依赖的转变过程中饮用乙醇。此外，试点项目还 鼓励他们帮助弥合临床前研究和临床研究之间的差距。

The Pilot Project Component will provide a flexible means for developeing and exploring new research activities or directions for the TSRI-ARC, that can evolve into independently funded research projects. During Years 1-5 of the proposed funding period, the Pilot Project Component is planning to fund 8 different projects ( 6 x 2 yrs, 2 x 1 yr). Work conducted in these projects will provide new directions for the TSRI-ARC in developing successful federal grant applications, and in attracting several new investigators to our Center. Dr. George F. Koob, the Center Director will manage this Component and Dr. Friedbert Weiss, a senior member of the TSRI-ARC, will co-manage this Component. Pilot Project applications will be solicited from all TSRI-ARC affiliated investigators and to other investigators in the Center at Large. Each proposal will be evaluated for scientific merit/innovation and several other criteria by at least two members of the Center's External Scientific Advisory Board and the Center Director or Co-Director. Recommendations for funding will be considered for approval by the Center Executive Committee. Four Pilot Projects are proposed for Year 1- 2, 2 pilots for Years 3-4 and 2 pilots for Year 5. Pilot 1 (Principal Investigator, Pietro Sanna, M.D.), is designed to explore the role of the protein kinase inhibitor alpha system during the course of bingeing and dependence in rats using the animal models of the TSRI-ARC. Pilot 2 (Principal Investigator, Michael Taffe, Ph.D.) is designed to explore an animal model of binge drinking in a nonhuman primate model (rhesus monkeys) and possible neuropharmacological effects of binge drinking in this model. . Pilot 3 (Principal Investigator, John Polich, Ph. D.) is designed to explore a neuroelectric phenotype for low and high drinkers will be characterized in young adults and will provide key information about changes in nervous system processing associated with heavy alcohol consumption in young adults. Pilot 4 (Principal Investigator, Cindy Ehlers, Ph. D.) is designed to compare subjective responses to ethanol and genetic differences in low and high drinkers study of young adult binge drinkers of a unique ethnic background (East Indian and African origin) in Trinidad. Pilot Projects selected for funding during Years 1-2 will bring new investigators to the TSRI-ARC and are expected to enrich the Center's overall research effort by extending the study of molecular mechanisms underlying ethanol neuroadaptation in the neurocircuits responsible for excessive drinking of ethanol during the transition from binge drinking to dependence. In addition, Pilot Projects have been encouraged to help bridge the gap between the preclinical and clinical studies.