Component 11: Pilot

第 11 部分：试点

• 批准号: 7497311
• 负责人: George F. Koob
• 金额: $ 30.09万
• 依托单位: SCRIPPS RESEARCH INSTITUTE, THE
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-25 至 2012-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7497311
• 关键词: African; Alcohol consumption; Animal Model; Applications Grants; Clinical Research; Consensus; Data; Dependence; Descriptor; Doctor of Medicine; Doctor of Philosophy; East Indian; Ethanol; Evaluation; Funding; Future; Genetic; Goals; Heavy Drinking; Lead; Macaca mulatta; Methods; Modeling; Molecular; Nervous system structure; Occupational activity of managing finances; Phenotype; Pilot Projects; Principal Investigator; Process; Progress Reports; Protein Kinase Inhibitors; Qualifying; Rate; Rattus; Recommendation; Recruitment Activity; Research; Research Activity; Research Personnel; Research Project Grants; Rest; Role; Scientific Evaluation; Scientist; Seeds; System; Time; Trinidad; United States National Institutes of Health; Update; Work; Writing; alcohol research; alcohol response; binge drinker; binge drinking; design; innovation; member; neuroadaptation; nonhuman primate; pre-clinical; programs; protein kinase inhibitor; young adult

The Pilot Project Component will provide a flexible means for developeing and exploring new research activities or directions for the TSRI-ARC, that can evolve into independently funded research projects. During Years 1-5 of the proposed funding period, the Pilot Project Component is planning to fund 8 different projects ( 6 x 2 yrs, 2 x 1 yr). Work conducted in these projects will provide new directions for the TSRI-ARC in developing successful federal grant applications, and in attracting several new investigators to our Center. Dr. George F. Koob, the Center Director will manage this Component and Dr. Friedbert Weiss, a senior member of the TSRI-ARC, will co-manage this Component. Pilot Project applications will be solicited from all TSRI-ARC affiliated investigators and to other investigators in the Center at Large. Each proposal will be evaluated for scientific merit/innovation and several other criteria by at least two members of the Center's External Scientific Advisory Board and the Center Director or Co-Director. Recommendations for funding will be considered for approval by the Center Executive Committee. Four Pilot Projects are proposed for Year 1- 2, 2 pilots for Years 3-4 and 2 pilots for Year 5. Pilot 1 (Principal Investigator, Pietro Sanna, M.D.), is designed to explore the role of the protein kinase inhibitor alpha system during the course of bingeing and dependence in rats using the animal models of the TSRI-ARC. Pilot 2 (Principal Investigator, Michael Taffe, Ph.D.) is designed to explore an animal model of binge drinking in a nonhuman primate model (rhesus monkeys) and possible neuropharmacological effects of binge drinking in this model. . Pilot 3 (Principal Investigator, John Polich, Ph. D.) is designed to explore a neuroelectric phenotype for low and high drinkers will be characterized in young adults and will provide key information about changes in nervous system processing associated with heavy alcohol consumption in young adults. Pilot 4 (Principal Investigator, Cindy Ehlers, Ph. D.) is designed to compare subjective responses to ethanol and genetic differences in low and high drinkers study of young adult binge drinkers of a unique ethnic background (East Indian and African origin) in Trinidad. Pilot Projects selected for funding during Years 1-2 will bring new investigators to the TSRI-ARC and are expected to enrich the Center's overall research effort by extending the study of molecular mechanisms underlying ethanol neuroadaptation in the neurocircuits responsible for excessive drinking of ethanol during the transition from binge drinking to dependence. In addition, Pilot Projects have been encouraged to help bridge the gap between the preclinical and clinical studies.

试点项目组件将为开发和探索新研究提供灵活的手段 TSRI-ARC的活动或方向，可以演变为独立资助的研究项目。 在拟议的融资期的1 - 5年中，试点项目组成部分计划为8个不同 项目（6 x 2年，2 x 1年）。在这些项目中进行的工作将为TSRI-ARC提供新的方向 在开发成功的联邦赠款申请中，并吸引了几位新的调查人员进入我们的中心。 中心主任乔治·F·科布（George F. TSRI-ARC的成员将共同管理此组件。试点项目申请将从 所有TSRI-ARC都隶属于研究人员和整个中心的其他研究人员。每个建议将是 该中心的至少两个成员评估了科学功绩/创新和其他几个标准 外部科学咨询委员会和中心主任或联合导演。资金的建议将 被中心执行委员会批准。提出了四个试点项目，为1年级 - 2，2年3 - 4年的飞行员和2年的2年飞行员。 旨在探讨在暴饮暴食过程中蛋白激酶抑制剂α系统的作用 使用TSRI-ARC的动物模型在大鼠中的依赖性。飞行员2（首席研究员，迈克尔·塔夫（Michael Taffe）， 博士学位）旨在探索非人类灵长类动物模型中暴饮暴食的动物模型（恒河猴 猴子）和该模型中暴饮暴食的神经药理作用。 。飞行员3（校长 研究员，约翰·波利奇（John Polich），博士D.）旨在探索低饮酒者和高饮酒者的神经电性表型 将以年轻人为特征，并将提供有关神经系统变化的关键信息 与年轻人大量饮酒有关的处理。飞行员4（辛迪首席研究员 Ehlers，Ph。D。）旨在比较低和低的乙醇和遗传差异的主观反应 高饮酒者研究具有独特种族背景的年轻成人暴饮暴食者（东印度和非洲人 起源于特立尼达。在1 - 2年内，选择用于资金的飞行员项目将把新调查人员带到 TSRI-ARC，并有望通过扩展研究中心的整体研究工作 在神经信中的乙醇神经适应的分子机制，导致过度 从暴饮暴食到依赖的过渡过程中饮用乙醇。此外，飞行员项目有 鼓励促进临床前研究和临床研究之间的差距。