Component 3: Animal Core

第 3 部分：动物核心

• 批准号: 7497300
• 负责人: George F. Koob
• 金额: $ 20.88万
• 依托单位: SCRIPPS RESEARCH INSTITUTE, THE
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-25 至 2012-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7497300
• 关键词: Abstinence; Acute; Adolescence; Adolescent; Adult; Age Factors; Alcohol consumption; Alcohol dependence; Alcohol withdrawal syndrome; Alcoholic Intoxication; Alcoholism; Alcohols; Animal Model; Animals; Blood; Blood alcohol level measurement; Characteristics; Chronic; Communities; Consumption; Data; Dependence; Development; Estrous Cycle; Ethanol; Female; Foundations; Funding; Gender; Genetic; Genetic Predisposition to Disease; Goals; Grant; Guidelines; Heavy Drinking; Indium; Modeling; Neurobiology; Pap smear; Phase; Process; Purpose; Rattus; Recording of previous events; Relapse; Relative (related person); Reliance; Research; Research Institute; Research Personnel; Self Administration; Self-Administered; Solutions; Staging; Testing; Time; Withdrawal; Work; addiction; alcohol effect; alcohol research; allostasis; base; binge drinking; drinking; vapor

The Animal Models Core of the Alcohol Research Center-The Scripps Research Institute (TSRI-ARC) aims has developed and will continue to refine new animal models of alcoholism to provide a framework for testing the overall hypotheses in the TSRI-ARC and the Center at Large. New directions in animal models core include a separation of excessive drinking into two domains: binge drinking, which will be defined by excessive ethanol intake associated with access to a sweet solution under limited access at the beginning of the dark cycle (Self-administered binge drinking-SABD) and withdrawal-induced drinking which will be defined as excessive ethanol consumption during acute and protracted withdrawal after dependence induction (Chronic ethanol induced drinking- CEID). Efforts will be particularly centered on broadening these models to the framework of allostasis, and to the factors of age, gender, and genetic vulnerability. For example, superimposed on these models will be developmental exposure which will include adolescent and adult exposure where excessive drinking during adolescence can serve as both a dependent variable (relative sensitivity of adolescent rats to excessive drinking) and as an independent variable (effects of adolescent exposure on subsequent binge and dependence drinking). In addition to further developing and providing guidelines for animal the animal models, the core will also provide alcohol vapor exposure, measurement of blood alcohol levels, and vaginal smears to the research components of our TSRI-ARC and the Center at Large

酒精研究中心的动物模型核心-斯克里普斯研究所（TSRI-ARC）的目标 已经开发并将继续完善新的酒精中毒动物模型，为测试提供框架 TSRI-ARC和中心的总体假设。动物模型的新方向 包括将过度饮酒分为两个领域：酗酒，其定义为 过量的乙醇摄入与在开始时有限的接触下获得甜味溶液相关， 黑暗周期（自我放纵饮酒-SABD）和戒断诱导饮酒， 定义为依赖后急性和长期戒断期间过量乙醇消耗 慢性酒精诱导饮酒（CEID）。努力将特别集中在扩大这些 模型的框架，以及年龄，性别和遗传脆弱性的因素。为 例如，在这些模型上叠加的是发育暴露，其中包括青少年和 成人暴露，其中青春期过量饮酒既可作为因变量， （青春期大鼠对过量饮酒的相对敏感性）和作为自变量（ 青少年暴露于随后的狂饮和依赖性饮酒）。除了进一步发展和 为动物模型提供指导，核心还将提供酒精蒸汽暴露， 血液酒精水平的测量，阴道涂片到我们的TSRI-ARC的研究组成部分， 大中心