Component 3: Animal Core

第 3 部分：动物核心

• 批准号: 7497300
• 负责人: George F. Koob
• 金额: $ 20.88万
• 依托单位: SCRIPPS RESEARCH INSTITUTE, THE
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-25 至 2012-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7497300
• 关键词: Abstinence; Acute; Adolescence; Adolescent; Adult; Age Factors; Alcohol consumption; Alcohol dependence; Alcohol withdrawal syndrome; Alcoholic Intoxication; Alcoholism; Alcohols; Animal Model; Animals; Blood; Blood alcohol level measurement; Characteristics; Chronic; Communities; Consumption; Data; Dependence; Development; Estrous Cycle; Ethanol; Female; Foundations; Funding; Gender; Genetic; Genetic Predisposition to Disease; Goals; Grant; Guidelines; Heavy Drinking; Indium; Modeling; Neurobiology; Pap smear; Phase; Process; Purpose; Rattus; Recording of previous events; Relapse; Relative (related person); Reliance; Research; Research Institute; Research Personnel; Self Administration; Self-Administered; Solutions; Staging; Testing; Time; Withdrawal; Work; addiction; alcohol effect; alcohol research; allostasis; base; binge drinking; drinking; vapor

The Animal Models Core of the Alcohol Research Center-The Scripps Research Institute (TSRI-ARC) aims has developed and will continue to refine new animal models of alcoholism to provide a framework for testing the overall hypotheses in the TSRI-ARC and the Center at Large. New directions in animal models core include a separation of excessive drinking into two domains: binge drinking, which will be defined by excessive ethanol intake associated with access to a sweet solution under limited access at the beginning of the dark cycle (Self-administered binge drinking-SABD) and withdrawal-induced drinking which will be defined as excessive ethanol consumption during acute and protracted withdrawal after dependence induction (Chronic ethanol induced drinking- CEID). Efforts will be particularly centered on broadening these models to the framework of allostasis, and to the factors of age, gender, and genetic vulnerability. For example, superimposed on these models will be developmental exposure which will include adolescent and adult exposure where excessive drinking during adolescence can serve as both a dependent variable (relative sensitivity of adolescent rats to excessive drinking) and as an independent variable (effects of adolescent exposure on subsequent binge and dependence drinking). In addition to further developing and providing guidelines for animal the animal models, the core will also provide alcohol vapor exposure, measurement of blood alcohol levels, and vaginal smears to the research components of our TSRI-ARC and the Center at Large

酒精研究中心的动物模型核心 - 斯克里普斯研究所（TSRI-ARC）的目标 已经开发并将继续完善新的酒精中毒模型，以提供测试的框架 TSRI-ARC和整个中心的总体假设。动物模型核心中的新方向 包括将过量饮酒分为两个领域：暴饮暴食，这将由 在有限的访问开始时，与获得甜溶液有关的乙醇摄入过多 黑暗周期（自我管理的暴饮暴食萨布）和戒断引起的饮酒将是 定义为在急性和长时间退出期间过度消耗乙醇 诱导（慢性乙醇诱导的饮酒）。努力将特别集中于扩大这些 模型与Allostasis的框架以及年龄，性别和遗传脆弱性的因素。为了 例如，在这些模型上叠加将是发展曝光，其中包括青少年和 成人暴露，青春期过量饮酒可以用作因变量 （青少年大鼠对过量饮酒的相对敏感性）和作为独立变量（影响的影响 青少年在随后的暴饮暴食和依赖饮酒中暴露）。除了进一步发展和 为动物模型提供指南，核心还将提供酒精蒸气暴露， 测量血液酒精水平以及阴道涂片，以使我们的TSRI-ARC的研究成分和 中心