Component 3: Animal Core

酒精研究中心的动物模型核心-斯克里普斯研究所(TSRI-ARC)旨在 已经开发并将继续完善酒精中毒的新动物模型，以提供测试框架 TSRI-ARC和该中心的总体假设。动物模型核心的新方向 包括将过度饮酒分为两个领域：酗酒，这将由 酒精摄入量过多与在初期接触有限的甜味溶液有关 黑暗循环(自我管理的狂欢饮酒-SABD)和戒断诱导饮酒 定义为在依赖后急性和长期戒断期间过量饮酒 诱导(慢性酒精诱发饮酒-CEID)。努力将特别集中在扩大这些 模型适用于异物平衡的框架，以及年龄、性别和遗传脆弱性等因素。为 例如，在这些模型上叠加的是发育暴露，其中将包括青少年和 青春期过度饮酒可作为因变量的成人暴露 (青春期大鼠对过量饮酒的相对敏感度)，并作为一个自变量( 青少年对随后的酗酒和依赖饮酒的暴露)。除了进一步开发和开发 为动物模型提供指南，核心还将提供酒精蒸气暴露， 对我们的TSRI-ARC和TSRI-ARC研究组件的血液酒精水平和阴道涂片的测量 自由的中心

The Animal Models Core of the Alcohol Research Center-The Scripps Research Institute (TSRI-ARC) aims has developed and will continue to refine new animal models of alcoholism to provide a framework for testing the overall hypotheses in the TSRI-ARC and the Center at Large. New directions in animal models core include a separation of excessive drinking into two domains: binge drinking, which will be defined by excessive ethanol intake associated with access to a sweet solution under limited access at the beginning of the dark cycle (Self-administered binge drinking-SABD) and withdrawal-induced drinking which will be defined as excessive ethanol consumption during acute and protracted withdrawal after dependence induction (Chronic ethanol induced drinking- CEID). Efforts will be particularly centered on broadening these models to the framework of allostasis, and to the factors of age, gender, and genetic vulnerability. For example, superimposed on these models will be developmental exposure which will include adolescent and adult exposure where excessive drinking during adolescence can serve as both a dependent variable (relative sensitivity of adolescent rats to excessive drinking) and as an independent variable (effects of adolescent exposure on subsequent binge and dependence drinking). In addition to further developing and providing guidelines for animal the animal models, the core will also provide alcohol vapor exposure, measurement of blood alcohol levels, and vaginal smears to the research components of our TSRI-ARC and the Center at Large