自愿暴饮暴食对青春期大鼠前额皮质的影响-猫眼课题宝

自愿暴饮暴食对青春期大鼠前额皮质的影响

批准号：

8463070

负责人：

Heather N. Richardson

金额：

$17.09万

依托单位：

UNIVERSITY OF MASSACHUSETTS AMHERST

依托单位国家：

美国

项目类别：

财政年份：

2012

资助国家：

美国

项目状态：

已结题

起止时间：

2012-05-01 至 2014-04-30

来源：

https://reporter.nih.gov/project-details/8463070

关键词：

Acute Adolescence Adolescent Adult Alcohol consumption Alcohols Antioxidants Axon Behavior Behavioral Biochemical Biochemical Markers Brain region Consumption Developmental Process Dietary Intervention Emotional Emotions Female Fiber Goals Harm Reduction Health High Prevalence Human Impulsive Behavior Intervention Knowledge Laboratory Study Link Literature Long-Term Effects Measures Methodology Modeling Myelin Outcome Oxidative Stress Pattern Play Prefrontal Cortex Process Public Health Rattus Recommendation Recording of previous events Research Rodent Role Self Administration Sex Characteristics Substance of Abuse Teenagers Testing Toxic effect Work addiction adolescent binge drinking alcohol measurement binge drinking clinical practice clinically relevant density early adolescence executive function fiber cell frontal lobe innovation interdisciplinary approach male neurotoxicity oxidative damage pre-clinical relating to nervous system remediation response underage drinking white matter

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DESCRIPTION (provided by applicant): The prefrontal cortex plays an executive role in the expression and control of emotion and goal-directed behaviors; yet, it is one of the last brain regions to mature. Of great concern is how "risky, impulsive behaviors" such as binge alcohol drinking in male and female teenagers may impacts maturational processes (e.g., myelinization) within the prefrontal cortex to have long-lasting consequences on psychiatric health. This proposal uses an innovative and clinically relevant model to elicit (and control) frequent bouts of voluntary binge drinking in male and female rats to investigate the causal effects, underlying mechanisms, and reversibility of adolescent binge drinking myelinated axons in prefrontal cortex.

期刊论文(4)

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会议论文

Myelination of Axons Corresponds with Faster Transmission Speed in the Prefrontal Cortex of Developing Male Rats.

DOI： 10.1523/eneuro.0203-18.2018

发表时间： 2018-07-01

期刊：

eNeuro

影响因子： 3.4

作者：

[McDougall, Sean, Vargas Riad, Wanette, Richardson, Heather N]