North Carolina Translational & Clinical Sciences Institute (NC TraCS)

北卡罗来纳州翻译

• 批准号: 8721096
• 负责人: MARSCHALL S. RUNGE
• 金额: $ 16.96万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-26 至 2018-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8721096
• 关键词: Advocate; Award; Basic Science; Biomedical Research; Characteristics; Clinical Research; Clinical Sciences; Clinical Trials; Clinical and Translational Science Awards; Commit; Communities; Development; Education; Ensure; Environment; Ethnic Origin; Evaluation; Faculty; Feedback; Foundations; Fruit; Funding; Funding Agency; Gender; Goals; Health; Health Policy; Health Sciences; Home environment; Human; Individual; Institutes; Institution; Instruction; International; Investments; K-Series Research Career Programs; Leadership; Learning; Mentors; Methods; Metric; Modeling; Nature; North Carolina; Outcome; Patients; Policies; Principal Investigator; Race; Research; Research Infrastructure; Research Personnel; Research Training; Resources; Role; Science; Services; Students; Technology; Testing; Time; Training; Training Programs; Training Support; Training and Education; Translational Research; U-Series Cooperative Agreements; United States National Institutes of Health; Vision; Work; base; career development; clinical application; clinical practice; comparative effectiveness; drug development; effectiveness research; experience; improved; innovation; meetings; member; next generation; pre-doctoral; programs; research study; success; uptake

Five years after its formation, the Clinical and Translational Science Award (CTSA) at the Univeristy of North Carolina at Chapel Hill (UNC), the North Carolina Translational and Clinical Sciences Institute (NC TraCS), has become the integrated, campus-wide home for clinical and translational research at UNC. The overall goal of this U54 Cooperative Agreement application is to combine the research strengths, resources and opportunities at UNC and new partner, RTI International (RTI), to build on the foundation established in the CTSA's last five years. NC TraCS will work to improve human health by accelerating clinical and translational research from health science discovery to dissemination to patients and communities. NC TraCS will strive to overcome the well-documented barriers to the effective, sustained translation of research discovery along the translational research continuum by improving efficiency, training a research workforce and exporting successful, validated methods developed in NC TraCS to other CTSA institutions and the public. The proposed CTSA will specifically (1) amplify a thriving CTSA program to the point that it supports the full spectrum of clinical and translational research; (2) leverage CTSA resources and institutional strengths to create a critical, sustained focus on three strategic initiatives: (a) next-generation technologies to transform the very nature of clinical research and practice, (b) new paradigms and resources to accelerate drug development, and (c) robust comparative effectiveness research studies to provide definitive evidence of the benefits and harms of tests and treatments; and (3) train, support and incentivize the next generation of clinical and translational science researchers. These goals will be accomplished by three resources, six services, integrated and streamlined from the original 11, and the three strategic initiatives. UNC and RTI now have a unique set of research and training resources to support the full range of clinical and translational research, from basic science to clinical application to policy change. NC TraCS will leverage the opportunity of this CTSA application to garner >$60 million dollars in matching institutional support to extend our capabilities to meet the three aims. In partnership with RTI, NC TraCS will take advantage of the resources it has created and nourished during the past five years to quickly and effectively bring the fruits of research to patients across the state, as well as nationally through the CTSA Consortium. RELEVANCE (See instructions): Researchers, clinicians and health policy experts have long lamented the well-documented lag between basic science discoveries and when those discoveries reach patients to treat them and make their lives better. The proposed UNC-RTI partnership in cooperation with the CTSA Consortium will help to ensure that patients will more quickly and effectively benefit from the results of biomedical research.

在成立五年后，北方大学的临床和翻译科学奖(CTSA) 北卡罗来纳州翻译和临床科学研究所(NC TraCS)， 已经成为北卡罗来纳大学临床和转化研究的综合、全校范围的中心。整体而言 U54合作协议申请的目标是将研究力量、资源和 在UNC和新的合作伙伴RTI International(RTI)的机会，以在 CTSA的最后五年。NC TraCS将通过加快临床和 从健康科学发现到传播到患者和社区的转化研究。NC TRACS将努力克服有效、持续地将研究成果翻译成文件的障碍 通过提高效率、培训研究队伍，沿着翻译研究连续体进行发现 并将在NC TraCS中开发的成功、有效的方法输出到其他CTSA机构和 公开的。拟议的CTSA将具体(1)扩大蓬勃发展的CTSA计划，使其能够支持 全面的临床和转化性研究；(2)利用CTSA资源和机构 将重点放在三项战略举措上的优势：(A)下一代技术 转变临床研究和实践的本质，(B)加快新的范例和资源 药物开发；和(C)强有力的比较有效性研究，以提供确凿证据 测试和治疗的益处和危害；以及(3)培训、支持和激励下一代 临床和转化科学研究人员。这些目标将通过三个资源实现，六个 服务，从原来的11个合并和精简，以及三个战略举措。 北卡罗来纳大学和RTI现在拥有一套独特的研究和培训资源，以支持全面的 临床和转化性研究，从基础科学到临床应用再到政策变化。NC TraCS将 利用此CTSA申请的机会，在匹配的机构中获得6,000万美元 支持扩大我们的能力，以实现这三个目标。与RTI合作，NC TraCS将采取 利用它在过去五年创造和滋养的资源，迅速有效地 通过CTSA联盟将研究成果带给全州和全国的患者。 相关性(请参阅说明)： 研究人员、临床医生和卫生政策专家长期以来一直对有充分证据证明的 基础科学发现，以及当这些发现到达患者手中治疗他们并创造他们的生活时 好多了。拟议的与CTSA联盟合作的UNC-RTI伙伴关系将有助于确保 患者将更快、更有效地从生物医学研究成果中受益。