2013 Epithelial Differentiation and Keratinization GRC/GRS

描述(由申请者提供)：2013年戈登上皮分化和角质化研究会议(GRC-EDK)是上皮和皮肤生物学领域的首要国际会议，该领域的国际领导者定期出席和申请者池的规模证明了这一点。GRC-EDK自1979年以来每两年举行一次，反映和促进了上皮生物学从主要的生化分析到分子、细胞、遗传和发育方法、干细胞生物学、再生医学、衰老、表观遗传学和基因组学的演变。这一成功是通过将对皮肤和上皮生物学的强烈关注与对新概念和技术方法的开放相结合而实现的。2013年，我们邀请了上皮生物学领域的领先研究人员和具有创新精神和令人兴奋的研究项目的早期职业科学家。该计划涵盖了持续感兴趣的领域，如干细胞、再生和衰老、上皮黏附和极性、罕见疾病和上皮性癌症，并探索了新的主题，包括肠道和皮肤的微生物区系，活体成像的进展，以及了解癌症发生和进化的基因组学方法。为了促进对新想法的讨论，25%的受邀演讲者来自直接领域以外的领域。为确保年轻的研究人员有机会作口头陈述，并容纳最新的发现，预留了整个会议和另外两个时段，供口头陈述从提交的摘要中挑选出来。该项目非常重视转化医学，整个课程都致力于新的疗法。为了促进学术医学和工业之间的合作，我们邀请了一位来自生物技术和具有强大工业联系的学术科学家的演讲者。会议相对孤立的地点和居住性质，以及非正式的下午时段，最大限度地增加了科学讨论的机会。2013年，我们正式承诺发展学员的职业生涯，在GRC-EDK之前举办了首届戈登上皮分化和角质化研究研讨会(GRS-EDK)。GRS会议由见习科学家组织，并以见习科学家为特色，为受训人员提供了一个独特的场所，让他们在支持性环境中展示他们的研究，与同行建立网络，并发展终身合作。主要的GRC-EDK会议是：(1)感觉上皮；(2)干细胞与再生；(3)上皮细胞骨架、黏附和极性；(4)上皮屏障、炎症、免疫功能和微生物组；(5)皮肤、皮肤附属物和色素系统的发育和发育；(6)上皮癌的机制；(7)引起的问题；(8)新的调节机制和研究方法；(9)新的治疗方法。2013年GRC/GRS-EDK反映了我们的目标，即展示、讨论和促进上皮生物学的前沿研究；促进关键研究成果的临床实践；以及促进学员的职业生涯。要求国立卫生研究院提供注册费用，特别是为受训人员和 年轻的调查员。

DESCRIPTION (provided by applicant): The 2013 Gordon Research Conference on Epithelial Differentiation and Keratinization (GRC-EDK) is the premier international meeting in epithelial and cutaneous biology, evidenced by the regular attendance of international leaders in this field and by the size of the applicant pool. The GRC-EDK has been held bi-annually since 1979 and has both reflected and promoted the evolution of epithelial biology from primarily biochemical analyses, to molecular, cellular, genetic and developmental approaches, stem cell biology, regenerative medicine, aging, epigenetics and genomics. This success has been achieved by combining a strong focus on cutaneous and epithelial biology with openness to new concepts and technical approaches. For 2013, we have invited leading investigators in epithelial biology and early career scientists with innovative and exciting research programs. The program covers areas of persistent interest such as stem cells, regeneration and aging, epithelial adhesion and polarity, rare diseases, and epithelial cancers, and explores new topics including microbiota of intestine and skin, advances in live imaging, and genomics approaches to understanding carcinogenesis and evolution. To promote discussion of new ideas, >25% of the invited speakers are from outside the immediate field. An entire session and 2 additional slots are reserved for oral presentations selected from submitted abstracts, to ensure opportunities for young investigators to give oral presentations, and to accommodate late-breaking discoveries. The program has a strong emphasis on translational medicine, with an entire session devoted to novel therapeutics. To promote collaboration between academic medicine and industry, we have invited a speaker from biotech and academic scientists with strong industrial ties. The relatively isolated location and residential nature of the Conference, and the informal afternoon periods, maximize opportunities for scientific discussions. For 2013, we have formalized our commitment to developing the careers of trainees by establishing the first Gordon Research Seminar on Epithelial Differentiation and Keratinization (GRS-EDK) to be held immediately preceding the GRC-EDK. GRS meetings are organized by, and feature, trainee scientists and provide a unique venue for trainees to present their research in a supportive environment, network with peers, and develop life-long collaborations. The main GRC-EDK sessions are: (1) Sensory Epithelia; (2) Stem Cells and Regeneration; (3) Epithelial Cytoskeleton, Adhesion and Polarity; (4) Epithelial Barriers, Inflammation, Immune Functions and the Microbiome; (5) Development and Evo-Devo of Skin, Skin Appendages, and the Pigmentary System; (6) Mechanisms in Epithelial Cancer; (7) Issues Arising; (8) Novel Regulatory Mechanisms and Investigational Approaches; (9) Novel Therapeutic Approaches. The 2013 GRC/GRS-EDK reflect our Aims of presenting, discussing and facilitating cutting edge research in epithelial biology; promoting translation of key research findings to clinical practice; and furthering the careers of trainees. NIH support is requested for registration costs, particularly for trainees and young investigators.