Drug Dependence Through the Lifespan: US-Thai Training Program

摘要 终生药物依赖：泰国-耶鲁大学培训计划 药物依赖是一组慢性、非传染性疾病，构成全球公共卫生 给国际社会带来巨大的经济、社会和医疗成本的问题。发展中国家， 特别是，受影响不成比例的是，由于与 非法药物的生产，以及不太健全的体制基础设施(设施、人员和 研究)致力于了解、治疗和预防药物依赖障碍--问题 这往往是世界各地区特有的。在这个应用中，我们提出了一种协作研究培训 泰国曼谷朱拉隆功大学医学院之间的药物依赖方案(a 泰国领先的医学研究中心)和美国耶鲁大学医学院 建议为泰国受训人员提供主要培训机制，包括长期(1-2年)博士前和 博士后奖学金和短期和中期(1-6个月)微型奖学金。在整个过程中 在五年计划中，朱拉隆功的培训责任增加(随着经验的积累)和减少 在耶鲁，因此在最后两年，泰国网站负责两个博士后全职教育。本节目 建立在耶鲁大学医学院关于药物依赖的广泛研究计划的基础上，以及 耶鲁大学调查员与朱拉隆功调查员之间现有的培训和研究合作 在泰国人群中药物依赖的遗传学研究中。该计划将有助于 朱拉隆功乃至泰国调查员进行最先进研究的能力 通过一系列培训经验(遗传学、流行病学、分子生物学、 临床、发育和翻译神经科学、精神药理学和临床试验，以及健康 服务和评价研究)。该计划明确的长期目标将是建立一个临界质量的 具有专业知识和可持续研究环境的科学家、卫生专业人员和学者 与中低收入国家合作，更好地了解、治疗和预防慢性非传染性疾病 药物依赖的传染性疾病。该培训计划也是专门为服务于 主要公共卫生目的是加强泰国抗击毒品依赖流行病的能力， 在它的历史上是前所未有的。

Abstract Drug Dependence Through the Lifespan: Thai-Yale Training Program Drug dependence is a set of chronic, non-communicable diseases that constitute a global public health problem of enormous economic, social, and medical cost to the international community. Developing countries, in particular, are disproportionately affected, due to both the economic incentives associated with the production of illicit drugs, and the less well-established institutional infrastructures (facilities, personnel, and research) dedicated to the understanding, treatment and prevention of drug dependence disorders - problems that are often specific to world regions. In this application, we propose a collaborative research training program in drug dependence between Faculty of Medicine, Chulalongkorn University in Bangkok, Thailand (a leading medical research center in Thailand) and the Yale University School of Medicine in the U.S. Three major training mechanisms are proposed for Thai trainees, including long-term (1-2-yr) predoctoral and postdoctoral fellowships, and short and intermediate-term (1-6 months) mini-fellowships. Over the course of the five year program, training responsibility increases at Chulalongkorn (as experience builds) and decreases at Yale, such that in the final two years the Thai site is responsible for two postdoctoral FTEs. This program builds on an extensive research program in drug dependence at Yale University School of Medicine, and on existing training and research collaborations between investigators at Yale and investigators at Chulalongkorn in the study of the genetics of drug dependence in Thai populations. The program will contribute to the capacity of investigators at Chulalongkorn and more generally in Thailand to conduct state-of-the-art research in substance dependence through a range of training experiences (genetics, epidemiology, molecular biology, clinical, developmental, and translational neuroscience, psychopharmacology and clinical trials, and health services and evaluation research). The explicit long-term goal of the program will be to build a critical mass of scientists, health professionals, and academics with expertise and a sustainable research environment at the collaborating lower-middle income country to understand better, treat, and prevent the chronic non- communicable disease of drug dependence. The training program is also specifically designed to serve a major public health purpose by enhancing Thailand's capacity to confront an epidemic of drug dependence that is unprecedented in its history.