Drug Dependence Through the Lifespan: US-Thai Training Program

摘要 终身药物依赖：泰国-耶鲁培训计划 药物依赖是构成全球公共卫生的一系列慢性非传染性疾病 这给国际社会带来了巨大的经济、社会和医疗成本。发展中国家， 特别是，由于与经济刺激有关的经济刺激， 非法药物的生产，以及不太完善的体制基础设施（设施，人员， 致力于了解、治疗和预防药物依赖性障碍-问题 通常是世界各地区特有的。在这个应用中，我们提出了一个合作研究培训 泰国曼谷朱拉隆功大学医学院药物依赖性方案（a 泰国领先的医学研究中心）和美国耶鲁大学医学院 主要的培训机制，建议泰国学员，包括长期（1-2年）的博士预科， 博士后研究金以及短期和中期（1-6个月）小型研究金。过程中 在五年计划中，朱拉隆功的培训责任增加（随着经验的积累）， 在耶鲁大学，这样，在最后两年的泰国网站负责两个博士后全职。这个程序 建立在耶鲁大学医学院广泛的药物依赖研究项目的基础上， 耶鲁大学和朱拉隆功大学的研究人员之间现有的培训和研究合作 研究泰国人群中药物依赖的遗传学。该计划将有助于 在朱拉隆功和更广泛的泰国进行最先进研究的调查能力 通过一系列培训经验（遗传学，流行病学，分子生物学， 临床，发育和转化神经科学，精神药理学和临床试验，以及健康 服务和评价研究）。该计划明确的长期目标是建立一个临界质量， 科学家，卫生专业人员和学者的专业知识和可持续的研究环境， 与中低收入国家合作，更好地了解、治疗和预防慢性非 药物依赖性传染病。培训计划也是专门为服务于 通过加强泰国应对药物依赖流行病的能力， 是史无前例的

Abstract Drug Dependence Through the Lifespan: Thai-Yale Training Program Drug dependence is a set of chronic, non-communicable diseases that constitute a global public health problem of enormous economic, social, and medical cost to the international community. Developing countries, in particular, are disproportionately affected, due to both the economic incentives associated with the production of illicit drugs, and the less well-established institutional infrastructures (facilities, personnel, and research) dedicated to the understanding, treatment and prevention of drug dependence disorders - problems that are often specific to world regions. In this application, we propose a collaborative research training program in drug dependence between Faculty of Medicine, Chulalongkorn University in Bangkok, Thailand (a leading medical research center in Thailand) and the Yale University School of Medicine in the U.S. Three major training mechanisms are proposed for Thai trainees, including long-term (1-2-yr) predoctoral and postdoctoral fellowships, and short and intermediate-term (1-6 months) mini-fellowships. Over the course of the five year program, training responsibility increases at Chulalongkorn (as experience builds) and decreases at Yale, such that in the final two years the Thai site is responsible for two postdoctoral FTEs. This program builds on an extensive research program in drug dependence at Yale University School of Medicine, and on existing training and research collaborations between investigators at Yale and investigators at Chulalongkorn in the study of the genetics of drug dependence in Thai populations. The program will contribute to the capacity of investigators at Chulalongkorn and more generally in Thailand to conduct state-of-the-art research in substance dependence through a range of training experiences (genetics, epidemiology, molecular biology, clinical, developmental, and translational neuroscience, psychopharmacology and clinical trials, and health services and evaluation research). The explicit long-term goal of the program will be to build a critical mass of scientists, health professionals, and academics with expertise and a sustainable research environment at the collaborating lower-middle income country to understand better, treat, and prevent the chronic non- communicable disease of drug dependence. The training program is also specifically designed to serve a major public health purpose by enhancing Thailand's capacity to confront an epidemic of drug dependence that is unprecedented in its history.