Drug Dependence Through the Lifespan: US-Thai Training Program

终生药物依赖：美国-泰国培训计划

• 批准号: 8184008
• 负责人: JOEL GELERNTER
• 金额: $ 25.49万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-08 至 2016-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8184008
• 关键词: Affect; Chronic; Clinical; Clinical Trials; Collaborations; Communicable Diseases; Communities; Country; Developing Countries; Development; Disease; Drug Addiction; Economics; Environment; Epidemic; Evaluation Research; Faculty; Fellowship; Genetic; Goals; Health Professional; Health Services Research; Illicit Drugs; Incentives; Income; International; Longevity; Medical; Medical Research; Medicine; Molecular Biology; Population; Prevention; Production; Psychopharmacology; Public Health; Recording of previous events; Research; Research Infrastructure; Research Personnel; Research Training; Scientist; Site; Substance Addiction; Thailand; Training; Training Programs; Universities; cost; design; experience; genetic epidemiology; medical schools; pre-doctoral; prevent; programs; social; translational neuroscience

DESCRIPTION (provided by applicant): Drug Dependence Through the Lifespan: Thai-Yale Training Program Drug dependence is a set of chronic, non-communicable diseases that constitute a global public health problem of enormous economic, social, and medical cost to the international community. Developing countries, in particular, are disproportionately affected, due to both the economic incentives associated with the production of illicit drugs, and the less well-established institutional infrastructures (facilities, personnel, and research) dedicated to the understanding, treatment and prevention of drug dependence disorders - problems that are often specific to world regions. In this application, we propose a collaborative research training program in drug dependence between Faculty of Medicine, Chulalongkorn University in Bangkok, Thailand (a leading medical research center in Thailand) and the Yale University School of Medicine in the U.S. Three major training mechanisms are proposed for Thai trainees, including long-term (1-2-yr) predoctoral and postdoctoral fellowships, and short and intermediate-term (1-6 months) mini-fellowships. Over the course of the five year program, training responsibility increases at Chulalongkorn (as experience builds) and decreases at Yale, such that in the final two years the Thai site is responsible for two postdoctoral FTEs. This program builds on an extensive research program in drug dependence at Yale University School of Medicine, and on existing training and research collaborations between investigators at Yale and investigators at Chulalongkorn in the study of the genetics of drug dependence in Thai populations. The program will contribute to the capacity of investigators at Chulalongkorn and more generally in Thailand to conduct state-of-the-art research in substance dependence through a range of training experiences (genetics, epidemiology, molecular biology, clinical, developmental, and translational neuroscience, psychopharmacology and clinical trials, and health services and evaluation research). The explicit long-term goal of the program will be to build a critical mass of scientists, health professionals, and academics with expertise and a sustainable research environment at the collaborating lower-middle income country to understand better, treat, and prevent the chronic non- communicable disease of drug dependence. The training program is also specifically designed to serve a major public health purpose by enhancing Thailand's capacity to confront an epidemic of drug dependence that is unprecedented in its history. PUBLIC HEALTH RELEVANCE: It is critically important to train a generation of researchers in Thailand who are equipped to address the issue of substance dependence in its various manifestations throughout the lifespan. The present proposal addresses this need by training researchers in the US, and by building capacity for future training at Chulalongkorn Faculty of Medicine, in Thailand.

药物依赖是一系列慢性非传染性疾病，构成了一个全球性的公共卫生问题，给国际社会带来巨大的经济、社会和医疗成本。发展中国家尤其受到不成比例的影响，这是由于与非法药物生产有关的经济刺激，以及专门用于了解、治疗和预防药物依赖性病症的体制基础设施（设施、人员和研究）不够完善-这些问题往往是世界各区域特有的。在本申请中，我们提出了泰国曼谷朱拉隆功大学医学院之间的药物依赖合作研究培训计划（泰国一家领先的医学研究中心）和美国耶鲁大学医学院为泰国学员提出了三个主要的培训机制，包括长期（1-2年）的博士前和博士后奖学金，以及短期和中期（1-6个月）小型研究金。在为期五年的计划中，朱拉隆功大学的培训责任增加（随着经验的积累），而耶鲁大学的培训责任减少，因此在最后两年，泰国研究中心负责两名博士后FTE。该计划建立在耶鲁大学医学院药物依赖的广泛研究计划基础上，以及耶鲁大学和朱拉隆功大学研究人员在泰国人群药物依赖遗传学研究中的现有培训和研究合作。该计划将有助于朱拉隆功和更广泛的泰国调查人员的能力，通过一系列培训经验（遗传学，流行病学，分子生物学，临床，发育和转化神经科学，精神药理学和临床试验，以及卫生服务和评估研究）进行物质依赖的最先进的研究。该计划的明确长期目标将是在合作的中低收入国家建立一个拥有专业知识和可持续研究环境的科学家，卫生专业人员和学者的临界质量，以更好地了解，治疗和预防慢性非传染性疾病药物依赖。该培训方案还专门为一个主要的公共卫生目的服务，提高泰国对付其历史上前所未有的药物依赖流行病的能力。 公共卫生相关性：至关重要的是，在泰国培训一代研究人员，使他们能够解决整个生命周期中各种表现形式的药物依赖问题。本提案通过在美国培训研究人员和在泰国朱拉隆功医学院建设未来培训能力来满足这一需求。