Drug Dependence Through the Lifespan: US-Thai Training Program

描述(申请人提供)：终身药物依赖：泰国-耶鲁大学培训计划药物依赖是一组慢性、非传染性疾病，构成了全球公共卫生问题，给国际社会带来了巨大的经济、社会和医疗成本。发展中国家尤其受到不成比例的影响，这既是因为与生产非法药物有关的经济激励，也是因为致力于了解、治疗和预防药物依赖障碍的机构基础设施(设施、人员和研究)不太健全--这些问题往往是世界区域特有的。在这项申请中，我们提出了泰国曼谷朱拉隆功大学医学院(泰国领先的医学研究中心)和美国耶鲁大学医学院之间关于药物依赖性的合作研究培训计划。为泰国学员提出了三种主要培训机制，包括长期(1-2年)博士后和博士后奖学金，以及短期和中期(1-6个月)微型奖学金。在五年计划期间，朱拉隆功的培训责任增加(随着经验的积累)，耶鲁大学的培训责任减少，因此在最后两年，泰国网站负责两个博士后FTE。该项目建立在耶鲁大学医学院广泛的药物依赖研究项目的基础上，以及耶鲁大学研究人员和朱拉隆功大学研究人员在泰国人口药物依赖遗传学研究方面的现有培训和研究合作的基础上。该计划将有助于朱拉隆功乃至泰国的研究人员通过一系列培训经验(遗传学、流行病学、分子生物学、临床、发育和翻译神经科学、精神药理学和临床试验，以及卫生服务和评估研究)在物质依赖方面进行最先进的研究。该计划明确的长期目标将是在这个合作的中低收入国家建立一批拥有专业知识和可持续研究环境的科学家、卫生专业人员和学者，以更好地了解、治疗和预防药物依赖这一慢性非传染性疾病。该培训计划还特别设计了一个主要的公共卫生目的，通过提高泰国对抗毒品依赖流行病的能力，这在其历史上是前所未有的。 与公共卫生相关：在泰国培训一代研究人员至关重要，他们有能力在一生中处理物质依赖的各种表现形式的问题。目前的建议通过在美国培训研究人员，以及在泰国朱拉隆功医学院建设未来培训能力来满足这一需求。

DESCRIPTION (provided by applicant): Drug Dependence Through the Lifespan: Thai-Yale Training Program Drug dependence is a set of chronic, non-communicable diseases that constitute a global public health problem of enormous economic, social, and medical cost to the international community. Developing countries, in particular, are disproportionately affected, due to both the economic incentives associated with the production of illicit drugs, and the less well-established institutional infrastructures (facilities, personnel, and research) dedicated to the understanding, treatment and prevention of drug dependence disorders - problems that are often specific to world regions. In this application, we propose a collaborative research training program in drug dependence between Faculty of Medicine, Chulalongkorn University in Bangkok, Thailand (a leading medical research center in Thailand) and the Yale University School of Medicine in the U.S. Three major training mechanisms are proposed for Thai trainees, including long-term (1-2-yr) predoctoral and postdoctoral fellowships, and short and intermediate-term (1-6 months) mini-fellowships. Over the course of the five year program, training responsibility increases at Chulalongkorn (as experience builds) and decreases at Yale, such that in the final two years the Thai site is responsible for two postdoctoral FTEs. This program builds on an extensive research program in drug dependence at Yale University School of Medicine, and on existing training and research collaborations between investigators at Yale and investigators at Chulalongkorn in the study of the genetics of drug dependence in Thai populations. The program will contribute to the capacity of investigators at Chulalongkorn and more generally in Thailand to conduct state-of-the-art research in substance dependence through a range of training experiences (genetics, epidemiology, molecular biology, clinical, developmental, and translational neuroscience, psychopharmacology and clinical trials, and health services and evaluation research). The explicit long-term goal of the program will be to build a critical mass of scientists, health professionals, and academics with expertise and a sustainable research environment at the collaborating lower-middle income country to understand better, treat, and prevent the chronic non- communicable disease of drug dependence. The training program is also specifically designed to serve a major public health purpose by enhancing Thailand's capacity to confront an epidemic of drug dependence that is unprecedented in its history. PUBLIC HEALTH RELEVANCE: It is critically important to train a generation of researchers in Thailand who are equipped to address the issue of substance dependence in its various manifestations throughout the lifespan. The present proposal addresses this need by training researchers in the US, and by building capacity for future training at Chulalongkorn Faculty of Medicine, in Thailand.