Methamphetamine and Other Substance Use Disorder Genetics in Thailand

泰国的甲基苯丙胺和其他药物使用障碍遗传学

基本信息

  • 批准号:
    10585560
  • 负责人:
  • 金额:
    $ 86.18万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2015
  • 资助国家:
    美国
  • 起止时间:
    2015-06-15 至 2028-04-30
  • 项目状态:
    未结题

项目摘要

Project Summary Methamphetamine use disorder (MUD) is a hugely destructive public health problem that is surging worldwide, including in many parts of the US and Asia. Thailand is an optimal site for studying the genetics of MUD, owing to lower genetic and environmental heterogeneity than in the US, and lower research costs, in the greater context of a devastating and widespread Thai epidemic of MUD, The Principal Investigators have formed the international relationships and established the logistical infrastructures necessary for human genetic studies of drug use disorders, including MUD, in Thailand, as shown during the prior iteration of this project; we collected >4000 MUD-informative subjects (cases and exposed controls), twice the promised sample. Leveraging our established and effective collaborations (Thanyarak Institute and Chulalongkorn University in Bangkok; Suan Prung Hospital in Chiang Mai), our successful prior work supports the feasibility of this project. We will collect and characterize a biobank sample for studies of substance use disorders (SUDs), especially MUD, as well as other psychiatric disorders and behaviors. 6000 subjects will be recruited in Bangkok (primarily at SUD treatment facilities) and 4000 in Chiang Mai (at Suan Prung, the major psychiatric hospital in the north of Thailand and in the community); 10,000 in total, balanced with equal numbers of cases and non-MUD matched controls. Subjects will be evaluated via the Thai MIND biobank instrument (the Thai version of an instrument developed for a Million Veteran Program (MVP) project from previously-validated assessment modules). All subjects' DNA will then be subjected to 3x low-pass whole-genome sequencing (WGS) at the Yale Center for Genome Analysis, variants called, and the dataset subjected to genomewide association analyses. WGS will allow the identification of common, rare, and copy number variants. We will undertake meta-analysis with other East Asian (e.g. Taiwan – 2200 cases, 4400 controls) populations to increase power, and conduct trans- ancestry meta-analyses with diverse ancestry groups (from the MVP sample and other large-scale biobanks and cohorts). Following the identification of risk variants, we will use multiple approaches to investigate and model MUD and other SUD polygenicity, and pleiotropy more broadly. We will also investigate the relationship between genetic risk for MUD and other psychiatric traits, and implement causal inference analysis to disentangle the pleiotropy of MUD with other psychiatric traits and disorders. Combining our newly-recruited Thai cohort with our earlier Thai sample and other samples of diverse ancestral backgrounds will permit us to fine-map MUD-associated loci and identify causal alleles across ancestry-specific LD patterns. Data will be made available to the Psychiatric Genomics Consortium and results shared broadly. Results from this study have the potential to advance greatly our understanding of genetic risk factors for MUD, especially in East Asian populations underrepresented in genetic studies, leading to an improved understanding of the neurobiology of MUD and, ultimately, improved approaches to its diagnosis, treatment, and prevention.
项目总结

项目成果

期刊论文数量(3)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Genomewide Association Study of Alcohol Dependence and Related Traits in a Thai Population.
Trends of cannabis use and related harms before and after legalization for recreational purpose in a developing country in Asia.
  • DOI:
    10.1186/s12889-023-15883-6
  • 发表时间:
    2023-05-19
  • 期刊:
  • 影响因子:
    4.5
  • 作者:
    Kalayasiri, Rasmon;Boonthae, Suriyan
  • 通讯作者:
    Boonthae, Suriyan
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JOEL GELERNTER其他文献

JOEL GELERNTER的其他文献

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{{ truncateString('JOEL GELERNTER', 18)}}的其他基金

The Robert T. Malison Yale-Chulalongkorn Stress, Alcohol Use and Psychopathology Training Program
罗伯特·T·马利森耶鲁-朱拉隆功压力、酒精使用和精神病理学培训计划
  • 批准号:
    10665205
  • 财政年份:
    2023
  • 资助金额:
    $ 86.18万
  • 项目类别:
Genomics of PTSD and Related Traits
PTSD 和相关特征的基因组学
  • 批准号:
    10292943
  • 财政年份:
    2019
  • 资助金额:
    $ 86.18万
  • 项目类别:
Genetics of Alcohol Dependence in African Americans: Recruitment
非裔美国人酒精依赖的遗传学:招募
  • 批准号:
    10474310
  • 财政年份:
    2018
  • 资助金额:
    $ 86.18万
  • 项目类别:
Genetics of Alcohol Dependence in African Americans: Recruitment
非裔美国人酒精依赖的遗传学:招募
  • 批准号:
    9769607
  • 财政年份:
    2018
  • 资助金额:
    $ 86.18万
  • 项目类别:
Identifying Methamphetamine Risk Variants by Extreme Phenotype Exome Sequencing
通过极端表型外显子组测序识别甲基苯丙胺风险变异体
  • 批准号:
    9086352
  • 财政年份:
    2015
  • 资助金额:
    $ 86.18万
  • 项目类别:
Identifying Methamphetamine Risk Variants by Extreme Phenotype Exome Sequencing
通过极端表型外显子组测序识别甲基苯丙胺风险变异体
  • 批准号:
    9280890
  • 财政年份:
    2015
  • 资助金额:
    $ 86.18万
  • 项目类别:
Identifying Methamphetamine Risk Variants by Extreme Phenotype Exome Sequencing
通过极端表型外显子组测序识别甲基苯丙胺风险变异体
  • 批准号:
    9920116
  • 财政年份:
    2015
  • 资助金额:
    $ 86.18万
  • 项目类别:
Identifying Methamphetamine Risk Variants by Extreme Phenotype Exome Sequencing
通过极端表型外显子组测序识别甲基苯丙胺风险变异体
  • 批准号:
    9456704
  • 财政年份:
    2015
  • 资助金额:
    $ 86.18万
  • 项目类别:
Genetics of Anxiety Disorders
焦虑症的遗传学
  • 批准号:
    8542156
  • 财政年份:
    2013
  • 资助金额:
    $ 86.18万
  • 项目类别:
Genetics of Anxiety Disorders
焦虑症的遗传学
  • 批准号:
    8794416
  • 财政年份:
    2013
  • 资助金额:
    $ 86.18万
  • 项目类别:

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与非洲血统相关的多发性骨髓瘤肿瘤生物学差异
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欧洲和非洲血统人群慢性阻塞性肺疾病的多组学风险预测_补充
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了解基因型与生活方式的相互作用对东非血统个体心脏代谢风险的影响
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