Regional Training Center for Tropical Disease Research in Quito-Ecuador

厄瓜多尔基多热带病研究区域培训中心

• 批准号: 8496159
• 负责人: MARIO J GRIJALVA
• 金额: $ 14.16万
• 依托单位: OHIO UNIVERSITY ATHENS
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-12 至 2015-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8496159
• 关键词: Algorithms; Biological; Chagas Disease; Clinical; Collaborations; Communicable Diseases; Country; Detection; Development; Diagnostic; Disease; Ecuador; Evaluation; Faculty; Fostering; Genotype; Health; Health Policy; Housing; Human Resources; Infectious Diseases Research; Institution; Knowledge; Lead; Methods; Morbidity - disease rate; Ohio; Pattern; Population Distributions; Positioning Attribute; Principal Investigator; Public Health; Research; Research Infrastructure; Research Personnel; Research Project Grants; Research Training; Role; Scientist; Solid; South America; Training; Training Programs; Tropical Disease; Trypanosoma cruzi; Universities; disorder control; improved; mortality; neglect; pre-doctoral; programs; sound; square foot; transmission process

DESCRIPTION (provided by applicant): The lack of adequately trained scientists and research infrastructure is the under lying cause of the lack of basic knowledge to guide the implementation and evaluation of effective public health programs as well as informed health policies in Ecuador. The overall objective of this proposal is to obtain biological and clinical information that will improve current Chagas disease control efforts in Ecuador, while implementing a sound and sustainable training program in infectious disease research. The training program proposed herein will take advantage of the strong collaborative relationship established in the 1990's between Ohio University (OU) and Catholic University of Ecuador (PUCE), and the track record of successful research and training collaboration carried out by these institutions. The program will focus on long term training at the postdoctoral and predoctoral levels. Trainee research projects will be nested into three ongoing interrelated research initiatives currently led by the P.D. and collaborating faculty in Ecuador. These initiatives include: 1. the development of improved standardized genotyping methods for T. cruzi, and their use for Trypanosoma cruzi strain characterization; 2. determination of Triatomine distribution and population flow, including house infestation and re-infestation patterns, and their relationship with T. cruzi genotypes; and 3. determination of the relationship between Chagas disease morbidity and mortality with T. cruzi strains present in the country and improvement of current case detection and diagnostic algorithms. The proposal contains a solid plan for the recruitment of trainees into technical and faculty positions that will be at PUCE. In addition, the program provides a framework for the recruitment of Ecuadorians who have received advanced degrees outside of Ecuador. The increase of in-house research expertise will lead to the establishment of a "Regional Training Center for Tropical Disease Research" in Quito-Ecuador. The program will be housed in a new 70,000 square feet building being constructed by PUCE in its new campus near Quito, to be completed by 2013. This facility will have the capacity to house the labs and offices of 16 principal investigators, associated staff, and research trainees. Overall, the proposed training program will help alleviate the severe lack of well trained technical personnel and researchers in Ecuador, foster the role of scientists as efficient public health policymakers, and have an important effect in the research capability of Ecuador. PULBIC HEALTH RELEVANCE: Ecuador lags far behind other countries of South America in terms of control of transmission of Chagas disease and other infectious diseases due in part to the lack of adequate research infrastructure and trained personnel. This training program will build the capacity of Catholic University of Ecuador to conduct high level research that can contribute to the control of this and other neglected diseases.

描述（由申请人提供）：缺乏训练有素的科学家和研究基础设施是缺乏基本知识的根本原因，以指导厄瓜多尔有效的公共卫生计划的实施和评估以及知情的卫生政策。该提案的总体目标是获得生物和临床信息，以改善厄瓜多尔目前的南美锥虫病控制工作，同时实施一项健全和可持续的传染病研究培训方案。本文提出的培训计划将利用俄亥俄州大学和厄瓜多尔天主教大学（PUCE）之间在20世纪90年代建立的强大的合作关系，以及这些机构开展的成功研究和培训合作的记录。该计划将侧重于博士后和博士前水平的长期培训。实习生研究项目将嵌套到三个正在进行的相互关联的研究计划，目前由P. D。和合作教师在厄瓜多尔。这些举措包括：1。改进T.克氏锥虫，以及它们用于克氏锥虫菌株表征的用途; 2.测定锥蝽分布和种群流动，包括房屋侵扰和再侵扰模式，以及它们与锥蝽的关系。cruzi基因型;和3.确定恰加斯病发病率和死亡率与T.该国存在的cruzi菌株以及改进现有病例检测和诊断算法。该提案包含了一个坚实的计划，招聘学员进入技术和教师职位，将在PUCE。此外，该方案还为招聘在厄瓜多尔境外获得高等学位的厄瓜多尔人提供了一个框架。内部研究专门知识的增加将导致在基多-厄瓜多尔建立一个“热带疾病研究区域培训中心”。该计划将被安置在一个新的70,000平方英尺的建筑正在建设的PUCE在其新校园附近基多，将于2013年完成。该设施将有能力容纳16名主要研究人员、相关工作人员和研究受训人员的实验室和办公室。总的来说，拟议的培训方案将有助于缓解厄瓜多尔严重缺乏训练有素的技术人员和研究人员的问题，促进科学家作为有效的公共卫生决策者的作用，并对厄瓜多尔的研究能力产生重要影响。 牙髓健康相关性：厄瓜多尔在控制南美锥虫病和其他传染病的传播方面远远落后于南美洲其他国家，部分原因是缺乏适当的研究基础设施和训练有素的人员。该培训方案将建设厄瓜多尔天主教大学开展高水平研究的能力，以有助于控制这种疾病和其他被忽视的疾病。