Cerenkov Tomography of 4D Radiation Therapy Plans

4D 放射治疗计划的切伦科夫断层扫描

• 批准号: 8643920
• 负责人: Brian W. Pogue
• 金额: $ 23.01万
• 依托单位: DARTMOUTH COLLEGE
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-30 至 2015-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8643920
• 关键词: Algorithms; American; Area; Calibration; Complex; Data; Data Set; Development; Disease; Dose; Ensure; External Beam Radiation Therapy; Fluorescence; Four-dimensional; Funding; Future; Gel; Goals; Hour; Image; Imagery; Individual; Intensity-Modulated Radiotherapy; Lateral; Left; Legal patent; Light; Linear Accelerator Radiotherapy Systems; Magnetic Resonance Imaging; Measures; Medical; Medicine; Methods; Monitor; Pathway interactions; Patients; Physics; Positron-Emission Tomography; Procedures; Process; Protocols documentation; Radiation; Radiation therapy; Recovery; Scanning; Spottings; System; Testing; Three-Dimensional Image; Time; Validation; Water; Work; base; cancer radiation therapy; cancer therapy; design; dosimetry; follow-up; image processing; imaging modality; improved; ionization; light emission; meetings; public health relevance; reconstruction; research study; simulation; tissue phantom; tomography; tool; treatment planning; validation studies

DESCRIPTION (provided by applicant): A newly discovered method for imaging radiation beam dose profiles from Cerenkov light emission will be studied and developed for real-time tomographic imaging of the advanced therapy treatment plans. Radiation therapy (RT) for cancer is one of the most technologically advanced areas of medicine today, utilizing state of the art CT, MRI, and PET imaging together with advanced treatment planning algorithms, to design patient specific delivery of radiation from a linear accelerator (LINAC). Despite this, the tools to characterize beams accuracy are extremely slow, and to date there is still no known way to visualize the beam in quickly. The importance of this new development cannot be overstated, in terms of its potential impact in the field of RT. Current procedures to measure beam dose in water tanks or tissue phantoms involve the use of ionization chambers, which are raster scanned in a 3D water tank, so that developing a 3D image of a beam would take the majority of a 24 hour day; therefore, it is rarely done. Yet, beam verification is required, and today only partial information is used in the commissioning process of new LINACs or in the verification of complex treatment plans. This newly discovered process of imaging the beam based upon the Cerenkov emission in the medium will allow instantaneous 2D imaging and very fast tomographic profiling of each beam planned. The preliminary data proving the potential of this proposal is already established, and will be followed up with a methodical development of a realization to image LINAC beams quickly with characterization of the accuracy. Systematic testing in standard medical physics water tank set ups will be completed with validation studies as outlined by the American Association of Physicists in Medicine. The accuracy of imaging advanced Intensity Modulated Radiation Therapy (IMRT) plans for cancer treatment will be studied to illustrate how imaging the planned delivery should improve accuracy. This work will be followed up through disease specific applications in future funding, following completion of this planned basic/translational period of development.

描述（由申请人提供）：将研究和开发一种新发现的用于成像来自切伦科夫光发射的辐射束剂量分布的方法，用于高级治疗计划的实时断层成像。癌症的放射治疗（RT）是当今医学技术最先进的领域之一，利用最先进的CT、MRI和PET成像以及先进的治疗计划算法，设计来自直线加速器（LINAC）的患者特定辐射输送。尽管如此，表征光束精度的工具非常缓慢，并且迄今为止仍然没有已知的方法来快速可视化光束。就其在RT领域的潜在影响而言，这一新发展的重要性不能被夸大。目前在水箱或组织幻影中测量射束剂量的程序涉及使用电离室，电离室在3D水箱中进行光栅扫描，因此开发射束的3D图像将花费24小时的大部分时间;因此，很少这样做。然而，束流验证是必需的，并且今天在新LINAC的调试过程中或在复杂治疗计划的验证中仅使用部分信息。这种新发现的基于介质中的切伦科夫发射的光束成像过程将允许对计划的每个光束进行瞬时2D成像和非常快速的断层扫描。证明这一建议的潜力的初步数据已经建立，并将随后与一个系统的发展，实现图像LINAC束快速与准确性的表征。标准医学物理水箱设置中的系统测试将通过美国医学物理学家协会概述的验证研究完成。成像先进的调强放射治疗（IMRT）计划的癌症治疗的准确性将进行研究，以说明如何成像计划的交付应提高准确性。这项工作将在完成计划的基本/转化开发期后，通过未来资助中的疾病特定应用进行后续工作。