Real-time Internal Calibration for Multiplexed Microarray Analysis
用于多重微阵列分析的实时内部校准
基本信息
- 批准号:8493750
- 负责人:
- 金额:$ 22.37万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2013
- 资助国家:美国
- 起止时间:2013-04-01 至 2015-03-31
- 项目状态:已结题
- 来源:
- 关键词:AccountingAddressAdsorptionAnalytical ChemistryAntigensBiological AssayCalibrationClinical ChemistryComputer SimulationConsumptionDataDetectionDevelopmentDiagnosticDiagnostic testsDiffusionEffectivenessEquilibriumEquipmentGenomicsHealthHealthcareHourHumanHuman ResourcesImmunoassayLaboratoriesMedicineMethodologyMethodsMetricMicroarray AnalysisMicrofabricationModalityModelingNanotechnologyPerformanceProteomicsRadialReagentResearch InfrastructureRotationSamplingSerumStagingStratificationTechniquesTechnologyTestingTimeValidationViscosityWorkbasebiochipcombatcostcost effectivedesignexperienceinnovationinsightinstrumentationmetabolic abnormality assessmentprognosticpublic health relevanceresearch studysurfactant
项目摘要
DESCRIPTION (provided by applicant): There is a growing need for a highly efficient, simple, and easy to use quantitation method for multiplexed marker analyses. We hypothesize that differences in analyte flux to different addresses in a heterogeneous array-based platform can serve as an effective means to simultaneously determine the absolute concentration of a number of analytes with only the need to add a single calibrant to the sample. This proposal details a reduction to practice of technology that will afford a simple and cost-effective approach
to determine the concentration of each marker - irrespective of the number of markers - without requiring the creation of calibration curves or the use of calibrants. The platform is extensible -
meaning it could be deployed for genomic and metabolic studies as well as for platform proteomic assays - and could be applied to other readout methods.
描述(由申请人提供):人们越来越需要一种高效、简单、易于使用的定量方法来分析多重标记物。我们假设,在基于异质阵列的平台中,分析物通量到不同地址的差异可以作为一种有效的手段,同时确定许多分析物的绝对浓度,而只需要向样品中添加一种校准剂。这项建议详细说明了减少技术实践的方法,这将提供一种简单和具有成本效益的方法
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Marc D Porter其他文献
Marc D Porter的其他文献
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{{ truncateString('Marc D Porter', 18)}}的其他基金
Field-deployable platform for prognostic hepatic cancer screening in low-resource settings
可现场部署的平台,用于在资源匮乏的环境中进行预后性肝癌筛查
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9221887 - 财政年份:2017
- 资助金额:
$ 22.37万 - 项目类别:
Surface-enhanced Raman Spectroscopy Immunoassay for Detection of Category A Patho
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8695035 - 财政年份:2014
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$ 22.37万 - 项目类别:
Surface-enhanced Raman Spectroscopy Immunoassay for Detection of Category A Patho
用于检测 A 类病理的表面增强拉曼光谱免疫分析
- 批准号:
9278001 - 财政年份:2014
- 资助金额:
$ 22.37万 - 项目类别:
Surface-enhanced Raman Spectroscopy Immunoassay for Detection of Category A Patho
用于检测 A 类病理的表面增强拉曼光谱免疫分析
- 批准号:
8850810 - 财政年份:2014
- 资助金额:
$ 22.37万 - 项目类别:
Surface-enhanced Raman Spectroscopy Immunoassay for Detection of Category A Patho
用于检测 A 类病理的表面增强拉曼光谱免疫分析
- 批准号:
9067315 - 财政年份:2014
- 资助金额:
$ 22.37万 - 项目类别:
Real-time Internal Calibration for Multiplexed Microarray Analysis
用于多重微阵列分析的实时内部校准
- 批准号:
8636020 - 财政年份:2013
- 资助金额:
$ 22.37万 - 项目类别:
Nanoporous Gold: Extractive Substrate for High-Speed Ultrasensitive Bioassays
纳米多孔金:用于高速超灵敏生物测定的提取底物
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7661010 - 财政年份:2009
- 资助金额:
$ 22.37万 - 项目类别:
Nanoporous Gold: Extractive Substrate for High-Speed Ultrasensitive Bioassays
纳米多孔金:用于高速超灵敏生物测定的提取底物
- 批准号:
7764726 - 财政年份:2009
- 资助金额:
$ 22.37万 - 项目类别:
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