Field-deployable platform for prognostic hepatic cancer screening in low-resource settings

项目摘要/摘要 可以成功地预防或治愈癌症、心脏病和糖尿病等重大疾病 如果在发育早期被发现，可通过常规医生就诊和预防性筛查进行治疗。然而， 由于资源、地理位置的限制，世界上许多人口在医疗方面得不到充分的服务 和社会经济障碍。本项目的总体目标是开发一款便携、廉价、易用的手机。 使用可部署的护理点(POC)平台为许多 在这些服务不足的社区中，常见的、具有临床意义的疾病。用来发展我们的初步证据 在理念上，我们的综合团队将与蒙古的合作医生密切合作，在一个平台上 与肝细胞癌密切相关的肝细胞癌和乙肝、丙型肝炎的早期诊断， 这两种疾病在这个国家和周边地区都有很高的发病率。 我们建议开发一种便携式、易用、低成本的血液免疫吸附分析方法。 使用带有拉曼读数的定量垂直流动分析(Q-VFA)检测这些疾病的生物标志物。这 Platform基于犹他大学的大量工作，提供了一个简短的样本到 结果周转时间，例如可以由当地卫生保健工作者或社区进行管理 领袖。如果阳性，则需要转诊以进行进一步的诊断评估，并且患者可以被引导到他们的 最近的医疗机构。

PROJECT SUMMARY/ABSTRACT Preventative or curable major diseases such as cancer, heart disease, and diabetes can be successfully treated if detected early in their development via routine physician visits and preventative screening. However, many populations of the world are medically underserved due to resource limitations, geographical location and socio-economic barriers. The overall goal of this project is to develop a portable, inexpensive and easy-to- use point-of-care (POC) platform that can be deployed to prescreen such communities for many of the common, clinically significant diseases in these underserved communities. For development of our initial proof of concept, our integrative team will closely collaborate with partnering physicians in Mongolia on a platform for early diagnosis of hepatocellular carcinoma (HCC) and Hepatitis B and C, which are closely linked to HCC, both of which have a high incidence in this country and in the surrounding region. We propose the development of a portable, easy-to-use, low-cost immunosorbent assay for blood-borne biomarkers of these diseases using a quantitative vertical flow assay (q-VFA) with Raman readout. This platform, which is based on an extensive body of work at the University of Utah, provides a short sample-to- result turn-around-time and can be administered, for example, by a local health care worker or community leader. If positive, referral for further diagnostic evaluation is needed, and the patient can be directed to their nearest medical facility.