Multi-excitation magnetoacoustic imaging of tissue conductivities

组织电导率的多激励磁声成像

• 批准号: 8549244
• 负责人: BIN HE
• 金额: $ 17.92万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-30 至 2016-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8549244
• 关键词: 3-Dimensional; Acoustics; Algorithms; Benign; Biomedical Research; Biopsy; Breast; Breast Cancer Detection; Breast Cancer Early Detection; Cancerous; Cessation of life; Clinical; Clinical Research; Computer Simulation; Development; Diagnosis; Early Diagnosis; Early treatment; Electric Conductivity; Evaluation; Goals; Healthcare Systems; Human; Image; Imaging Techniques; Investigation; Life; Magnetism; Malignant Neoplasms; Mammary Neoplasms; Mammography; Measurement; Methods; Noise; Normal Range; Normal tissue morphology; Outcome; Pathology; Patients; Performance; Physiologic pulse; Property; Radiation; Reporting; Research; Resolution; Roentgen Rays; Sampling; Screening for cancer; Sensitivity and Specificity; Signal Transduction; Specificity; Specimen; System; Techniques; Technology; Testing; Time; Tissue Differentiation; Tissues; Ultrasonic Transducer; Ultrasonography; United States; Woman; Work; anticancer research; base; biomagnetism; breast lesion; cancer imaging; clinical Diagnosis; clinical application; cost effective; design; electric impedance; imaging modality; in vivo; innovation; magnetic field; malignant breast neoplasm; mortality; novel; novel strategies; performance tests; research study; screening; simulation; soft tissue; tissue phantom; tomography; tumor

DESCRIPTION (provided by applicant): Breast cancer is one of the most life-threatening tumors among women in U.S. There is considerable evidence that early diagnosis and treatment of breast cancer can significantly increase chances of survival. While X-ray mammography is the current standard screening technique, it is limited by its poor soft tissue differentiation and radiation exposure. Patients with positive mammographic findings require a biopsy for definitive diagnosis, and it was reported that biopsies of breast lesions identified in mammography screenings are negative for malignancy in a significant portion of the patients. We propose to develop a novel, cost-effective, non-ionizing, high resolution, and high specificity imaging system for imaging electrical conductivity by integrating biomagnetism with ultrasound (magnetoacoustic tomography with magnetic induction: MAT-MI) for screening and early detection of breast cancer. This proposed development is based on the experimental evidence that cancerous tissue shows significantly higher electrical conductivity value than normal and benign tissue. In this R21 project, we propose to explore and develop a 3-dimensional (3D) multi-excitation MAT-MI (meMAT-MI) system and evaluate it in computer simulations, phantom experiments, and breast specimen imaging, for the purpose of achieving high resolution, high specificity electrical impedance imaging throughout the volume with a cost effective system realization for breast cancer detection. In the proposed 3D meMAT-MI, the object is located in a static magnetic field and a time-varying pulsed magnetic field. Multiple pulsed magnetic stimulations will be applied to the object, which induce eddy current distributions in the object. Consequently, the sample will emit acoustic waves by the Lorentz force based on the interplay of induced currents and applied magnetic fields. The acoustic signals are collected around the object during multi-excitation to reconstruct images related with the electrical conductivity distribution in the object. Through multi-excitation using magnetic energy, we propose to reconstruct the complete electrical conductivity profiles throughout the volume of the object. We will develop and optimize the novel 3D meMAT-MI system, and assess its feasibility in computer simulations and phantom experiments. We will also test directly its performance in imaging breast tumors in human breast specimens. High resolution imaging of electrical impedance distribution is of significance for a variety of applications in biomedical research and clinical diagnosis, such as early cancer detection. The successful development of a high-resolution, non-ionizing, cost-effective electrical impedance imaging system will have a significant impact to screening and early detection of breast cancer.

描述（由申请人提供）：乳腺癌是美国妇女中最危及生命的肿瘤之一，有相当多的证据表明，乳腺癌的早期诊断和治疗可以显着增加生存机会。虽然X射线乳房摄影术是目前的标准筛查技术，但它受到软组织分化差和辐射暴露的限制。乳腺X线检查结果阳性的患者需要进行活检以进行明确诊断，据报告，在乳腺X线检查筛查中发现的乳腺病变的活检在很大一部分患者中为恶性肿瘤阴性。我们建议开发一种新型的，具有成本效益的，非电离的，高分辨率和高特异性的成像系统，通过将生物磁性与超声（磁声断层扫描与磁感应：MAT-MI）结合起来，用于乳腺癌的筛查和早期检测，以成像电导率。所提出的发展基于癌组织显示出比正常和良性组织显著更高的电导率值的实验证据。在这个R21项目中，我们建议探索和开发一个三维（3D）多激励MAT-MI（meMAT-MI）系统，并在计算机模拟，体模实验和乳腺标本成像中对其进行评估，以实现高分辨率，高特异性电阻抗成像的整个体积与成本效益的系统实现乳腺癌检测的目的。在所提出的3D meMAT-MI中，对象位于静态磁场和时变脉冲磁场中。多个脉冲磁刺激将被施加到对象，其在对象中感应涡流分布。因此，样品将通过基于感应电流和施加的磁场的相互作用的洛伦兹力发射声波。在多激励期间收集对象周围的声信号以重建与对象中的电导率分布相关的图像。通过使用磁能的多激励，我们建议重建整个对象的体积的完整的电导率分布。我们将开发和优化新型3D meMAT-MI系统，并评估其在计算机模拟和体模实验中的可行性。我们还将直接测试其在人类乳腺标本中成像乳腺肿瘤的性能。电阻抗分布的高分辨率成像对于生物医学研究和临床诊断（例如早期癌症检测）中的各种应用具有重要意义。高分辨率、非电离、低成本的电阻抗成像系统的成功开发将对乳腺癌的筛查和早期发现产生重大影响。