National Center for Pediatric Practice Based Research & Learning

描述(由申请人提供)：通过循证实践实现最佳的儿童保健结果。然而，循证实践需要基于实践的证据，初级保健实践和被称为基于实践的研究网络(PBRN)的诊所的联盟提供了一些最高质量和最普遍的基于实践的证据。然而，在初级保健环境中进行重要和及时的研究方面，PBRN面临着许多问题。主要挑战包括：(1)维护基础设施以解决初级保健研究的复杂工作；(2)积累足够大的成员实践队列，以解决数据集群带来的样本量问题；以及(3)聚集具有开展基于实践的研究所需的专业知识的知识和成熟的研究人员队列。个别儿科PBRN已经处理并部分解决了其中的一些挑战，但没有一个能够完全解决这些挑战。该项目的具体目标是： 1.将两个儿科PBRN联系起来：办公室环境中的儿科研究(PROS)，美国儿科学会(AAP)的PBRN--全国最大和第二古老的儿科PBRN(通过加入AAP的质量改进创新网络(QuIlN)而得到加强)，以及费城儿童医院(CHOP)的儿科研究联盟(PERC)--全国最具创新性的儿科PBRN，位于国家儿科实践研究和学习中心。2.加强和建立PROS/AAP和PERC/CHOP之间业已建立的工作关系3.利用PROS和PERC及其上级组织的传播和执行能力，在地方、区域和国家各级改进儿科初级保健的提供。 这些目标将通过中心行政和研究中心的协调活动来实现，以便对快速周期的筹资机会公告作出反应，以及开发由研究人员发起的初级保健研究。 公共卫生相关性：该项目承诺通过联合两个最成功的儿科实践研究网络，产生新的知识来推动初级保健儿科领域的发展。这些网络得到加强的基础设施不仅将支持知识创造，而且还将支持知识传播和实施循证儿科保健的直接努力。

DESCRIPTION (provided by applicant): The best child health care outcomes are achieved through evidence-based practice. Evidence-based practice, however, requires practice-based evidence, and the coalitions of primary care practices and clinics known as practice-based research networks (PBRNs) have provided some of the highest quality and most generalizable practice-based evidence. PBRNs face numerous problems, however, in conducting important and timely research in primary care settings. Principal challenges include (1) maintaining an infrastructure to address the complex work of primary care research; (2) amassing a large enough cohort of member practices to address the sample size issues presented by data clustering; and (3) aggregating a knowledgeable and sophisticated cohort of researchers with the expertise needed to conduct practice-based research. Individual pediatric PBRNs have dealt and partially solved some of these challenges, but none have been able to address them fully. The Specific Aims of this project are: 1. Link two pediatric PBRNs: Pediatric Research in Office Settings (PROS), the PBRN of the American Academy of Pediatrics (AAP) - the nation's largest and second oldest pediatric PBRN (enhanced by its affiliation with the AAP's Quality Improvement Innovation Network (QuIlN)), and the Pediatric Research Consortium (PeRC) of the Children's Hospital of Philadelphia (CHOP) - t h e nation's most innovative pediatric PBRN, in a national center for pediatric practice-based research and learning. 2. Enhance established and create new working relationships between PROS/AAP and PeRC/CHOP 3. Leverage the dissemination and implementation capacities of PROS and PeRC and their parent organizations to improve delivery of pediatric primary care at local, regional, and national levels. These aims will be achieved through coordinated activities of center administrative and research cores allowing for responses to rapid-cycle funding opportunity announcements as well as the development of investigator-initiated primary care research. PUBLIC HEALTH RELEVANCE: This project promises to generate new knowledge to advance the field of primary care pediatrics by allying two of the most successful pediatric practice-based research networks. The networks' enhanced infrastructure will support not only knowledge creation, but also knowledge dissemination and direct efforts to implement evidence-based pediatric care.