Clinical and Computational Support

核心B的作用是提供以下服务：(1)支持治疗计划，(2)质量 保证和提供参加项目1和项目2的临床试验的患者的治疗；(3)蒙特 所有四个项目的高速并行处理系统的卡罗计算和管理，以及(4) 体模中的测量，用于实验验证和验证计算的剂量分布 四个项目。 这一核心还将在实施通过研究产生的新方法方面发挥重要作用。 项目1至4.实例包括图像引导设置、呼吸门控、新方案评估 技术，体内剂量测定，减少边际，自适应重新规划和强度调制质子治疗。 针对项目1(非小细胞肺癌)和项目2(其他具有挑战性的地点)的具体治疗地点 将为1)固定、成像(包括重复成像和4D成像)和 建立治疗方案；(2)规划PSPT和IMPT，将研究成果纳入治疗计划 质子处理计划基础设施的设计和评估战略及维护；(3)质量 新的计划和治疗技术在临床实施前的保证；(4)患者的具体情况 剂量学质量保证；(5)图像引导设置和呼吸门控；以及(6)体内剂量学。 高速并行CPU集群系统将用于蒙特卡罗计算、优化和 所有四个项目的图像处理。 由于MGH和MDACC在设备、系统和工艺方面的差异，核心B具有 被分成两部分。核心B1将支持MGH活动，而核心B2将支持MDAcc 活动

The role of Core B is to provide the following services: (1) support for treatment planning, (2) quality assurance and delivery of treatments for patients enrolled in the clinical trials of Projects 1 and 2, (3) Monte Carlo computations and management of high-speed parallel processing system for all four projects, and (4) measurements in phantom for experimental verification and validation of computed dose distributions for all four projects. This core will also play a significant role in the implementation of new methods resulting from research in Projects 1 through 4. Examples include image-guided setup, respiratory-gating, new plan evaluation techniques, in vivo dosimetry, reduced margins, adaptive replanning and intensity modulated proton therapy. For Project 1 (non-small cell lung cancers) and Project 2 (other challenging sites) treatment site-specific support will be provided for 1) immobilization, imaging (including repeat imaging and 4D imaging) and treatment set up; (2) planning of PSPT and IMPT, incorporation of results of research into treatment plan design and evaluation strategies and maintenance of proton treatment planning infrastructure; (3) quality assurance of new planning and treatment techniques prior to their clinical implementation; (4) patient specific dosimetric quality assurance; (5) image-guided setup and respiratory-gating; and (6) in-vivo dosimetry. The high-speed parallel CPU cluster system will be used for Monte Carlo calculations, optimization and image processing for all four projects. Because of the differences in equipment, systems and processes between MGH and MDACC, Core B has been divided into two parts. Core B1 will support MGH activities whereas Core B2 will support the MDACC activities