Clinical and Computational Support

临床和计算支持

• 批准号: 8736219
• 负责人: Hanne M Kooy
• 金额: $ 13.61万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-04-01 至 2014-09-24
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8736219
• 关键词: 4D Imaging; Cancer Center; Clinical; Clinical Trials; Dose; Enrollment; Equipment; Evaluation; General Hospitals; Image; Immobilization; Maintenance; Massachusetts; Measurement; Methods; Nature; Non-Small-Cell Lung Carcinoma; Patients; Play; Process; Proton Radiation; Protons; Radiation therapy; Research; Research Infrastructure; Role; Services; Site; Speed; System; Techniques; Text; Therapeutic Studies; University of Texas M D Anderson Cancer Center; design; dosimetry; image processing; in vivo; parallel processing; proton therapy; quality assurance; respiratory; treatment planning; treatment site; verification and validation

The role of Core B is to provide the following services: (1) support for treatment planning, (2) quality assurance and delivery of treatments for patients enrolled in the clinical trials of Projects 1 and 2, (3) Monte Carlo computations and management of high-speed parallel processing system for all four projects, and (4) measurements in phantom for experimental verification and validation of computed dose distributions for all four projects. This core will also play a significant role in the implementation of new methods resulting from research in Projects 1 through 4. Examples include image-guided setup, respiratory-gating, new plan evaluation techniques, in vivo dosimetry, reduced margins, adaptive replanning and intensity modulated proton therapy. For Project 1 (non-small cell lung cancers) and Project 2 (other challenging sites) treatment site-specific support will be provided for 1) immobilization, imaging (including repeat imaging and 4D imaging) and treatment set up; (2) planning of PSPT and IMPT, incorporation of results of research into treatment plan design and evaluation strategies and maintenance of proton treatment planning infrastructure; (3) quality assurance of new planning and treatment techniques prior to their clinical implementation; (4) patient specific dosimetric quality assurance; (5) image-guided setup and respiratory-gating; and (6) in-vivo dosimetry. The high-speed parallel CPU cluster system will be used for Monte Carlo calculations, optimization and image processing for all four projects. Because of the differences in equipment, systems and processes between MGH and MDACC, Core B has been divided into two parts. Core B1 will support MGH activities whereas Core B2 will support the MDACC activities

核心 B 的作用是提供以下服务：(1) 治疗计划支持，(2) 质量 为参加项目 1 和 2 临床试验的患者提供治疗保证和提供，(3) Monte 所有四个项目的高速并行处理系统的 Carlo 计算和管理，以及 (4) 体模测量，用于实验验证和验证所有计算剂量分布 四个项目。 该核心还将在实施新方法的研究中发挥重要作用 项目 1 至 4。示例包括图像引导设置、呼吸门控、新计划评估 技术、体内剂量测定、缩小余量、适应性重新计划和调强质子治疗。 对于项目 1（非小细胞肺癌）和项目 2（其他具有挑战性的部位）治疗部位特定 将提供以下支持：1) 固定、成像（包括重复成像和 4D 成像）和 治疗设置； (2) PSPT和IMPT的规划，将研究结果纳入治疗计划 质子治疗规划基础设施的设计和评估策略以及维护； (3)质量 在临床实施之前确保新的规划和治疗技术； (4) 患者具体情况 剂量测定质量保证； (5) 图像引导设置和呼吸门控； (6)体内剂量测定。 高速并行CPU集群系统将用于蒙特卡罗计算、优化和 所有四个项目的图像处理。 由于 MGH 和 MDACC 之间的设备、系统和流程存在差异，Core B 已 被分为两部分。核心 B1 将支持 MGH 活动，而核心 B2 将支持 MDACC 活动