Computational Characterization of Genetic Heterogeneity
Computational Characterization of Genetic Heterogeneity
批准号:
8417550
负责人:
Benjamin Raphael
金额:
$37.3万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2013
资助国家:
美国
项目状态:
已结题
起止时间:
2013-09-01 至 2016-08-31
关键词:
AddressAlgorithmsAttentionBiologicalBiomedical ResearchClinicalClinical DataCollaborationsCollectionComputational TechniqueComputer softwareDNA SequenceDataData AnalysesDetectionDevelopmentDiagnosticDiseaseEpigenetic ProcessFrequenciesGene ClusterGene MutationGenesGeneticGenetic HeterogeneityGenomeHeterogeneityIndividualInheritedInstitutesKnowledgeLeadMalignant NeoplasmsMeasurementMedicineMethodsMutateMutationOvarianPathway interactionsReaction TimeRegulatory PathwayResearchResearch PersonnelSamplingSignal PathwaySomatic MutationSourceStatistical ModelsTechniquesTechnologyTestingThe Cancer Genome AtlasTimeUniversitiesVariantWashingtonWorkbasecancer genomecombinatorialdata sharingdesignepigenomegene interactiongenetic variantgenome sequencingnext generationnovelresponsesound
中文摘要
遗传异质性是许多疾病的共同特征,具有不同的因果变异,或者
突变,存在于不同的疾病患者中。遗传异质性使问题复杂化
确定疾病的遗传基础,因为任何中等规模的研究都将包含
具有不同因果遗传变异的个体。这种异质性的一个原因是
变异体存在于相互作用于各种细胞信号和调控的基因群中
小路。遗传异质性需要对变异组合进行测试,而不是
与疾病相关的个体变异。然而,虽然单个变体可以是
对关联进行了详尽的测试,变异的组合不能,因为有太多
要测试的组合,统计意义所需的样本数为
天文数字。我们建议开发新的计算和统计方法来识别
与疾病相关的变异的组合。与现有方法相比,
我们不会先验地把注意力限制在已知的途径或基因组上。相反,我们的算法
利用基因组规模的相互作用网络和组合/统计约束来识别
变异的组合,并严格评估其统计意义。此外,我们还扩展了
这些方法可以找到变异体的组合和不同临床病例之间的联系
生存时间或治疗反应等参数。我们将把这些技术应用于
癌症基因组测序项目,包括癌症基因组图谱(TCGA),在
与几个生物医学研究小组合作。圆满完成拟议中的
研究将促进遗传异质性疾病的研究--特别是癌症
-仅使用目前DNA测序可以获得的适度数量的样本
技术。
英文摘要
Genetic heterogeneity is a common feature of many diseases, with different causal variants, or
mutations, present in different individuals with the disease. Genetic heterogeneity complicates
the identification of the genetic basis of disease, as any modest sized study will contain
individuals with different causal genetic variants. One reason for this heterogeneity is that causal
variants are present in groups of genes that interact in various cellular signaling and regulatory
pathways. Genetic heterogeneity demands the testing of combinations of variants, rather than
individual variants, for association with a disease. However, while individual variants can be
tested exhaustively for association, combinations of variants cannot, as there are too many
combinations to test, and the number of samples required for statistical significance would be
astronomical. We propose to develop new computational and statistical approaches to identify
combinations of variants that are associated with a disease. In contrast to existing approaches,
we do not restrict attention to known pathways or groups of genes a priori. Rather, our algorithms
utilize genome-scale interaction networks and combinational/statistical constraints to identify
combinations of variants and rigorously assess their statistical significance. Further, we extend
these approaches to find associations between combinations of variants and various clinical
parameters such as survival time or response to treatment. We will apply these techniques to
cancer genome sequencing projects including The Cancer Genome Atlas (TCGA), in
collaboration with several biomedical research groups. Successful completion of the proposed
research will facilitate the study of genetically heterogeneous diseases - and in particular cancer
- using only a modest number of samples that is attainable with present DNA sequencing
technologies.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
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资助金额:$30.11万
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财政年份:2021
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Comprehensive and Robust Tools for Analysis of Tumor Heterogeneity and Evolution
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批准号:10269002
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Comprehensive and Robust Tools for Analysis of Tumor Heterogeneity and Evolution
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批准号:10700040
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资助金额:$61.86万
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财政年份:2020
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负责人:Benjamin Raphael
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依托单位:
Comprehensive and Robust Tools for Analysis of Tumor Heterogeneity and Evolution
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批准号:10059032
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项目类别:
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资助金额:$81.97万
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财政年份:2020
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负责人:Benjamin Raphael
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依托单位:
Comprehensive and Robust Tools for Analysis of Tumor Heterogeneity and Evolution
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批准号:10677268
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项目类别:
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资助金额:$8.1万
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财政年份:2020
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负责人:Benjamin Raphael
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依托单位:
Pathway and Network Integration of Cancer Genomics and Clinical Data
-
批准号:9765287
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项目类别:
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资助金额:$31.59万
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财政年份:2016
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负责人:Benjamin Raphael
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依托单位:
Pathway and Network Integration of Cancer Genomics and Clinical Data
-
批准号:9211127
-
项目类别:
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资助金额:$37.61万
-
财政年份:2016
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负责人:Benjamin Raphael
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依托单位:
BioMedical Big Data Core
-
批准号:8813144
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项目类别:
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资助金额:$73.67万
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财政年份:2016
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负责人:Benjamin Raphael
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依托单位:
Analytical Approaches to Massive Data Computation with Applications to Genomics
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批准号:8825472
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项目类别:
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资助金额:$7.13万
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财政年份:2013
-
负责人:Benjamin Raphael
-
依托单位:
Computational Characterization of Genetic Heterogeneity
-
批准号:8728985
-
项目类别:
-
资助金额:$36.14万
-
财政年份:2013
-
负责人:Benjamin Raphael
-
依托单位:
Analytical Approaches to Massive Data Computation with Applications to Genomics
-
批准号:8599823
-
项目类别:
-
资助金额:$7.13万
-
财政年份:2013
-
负责人:Benjamin Raphael
-
依托单位:
Analytical Approaches to Massive Data Computation with Applications to Genomics
-
批准号:8685211
-
项目类别:
-
资助金额:$6.92万
-
财政年份:2013
-
负责人:Benjamin Raphael
-
依托单位:
Computational Approaches for Structural Variation Studies in Genomes
-
批准号:8209046
-
项目类别:
-
资助金额:$49.05万
-
财政年份:2011
-
负责人:Benjamin Raphael
-
依托单位:
Computational Approaches for Structural Variation Studies in Genomes
-
批准号:8789371
-
项目类别:
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资助金额:$47.82万
-
财政年份:2011
-
负责人:Benjamin Raphael
-
依托单位:
Computational Approaches for Structural Variation Studies in Genomes
-
批准号:8041856
-
项目类别:
-
资助金额:$50.6万
-
财政年份:2011
-
负责人:Benjamin Raphael
-
依托单位:
Computational Approaches for Structural Variation Studies in Genomes
-
批准号:8425066
-
项目类别:
-
资助金额:$46.84万
-
财政年份:2011
-
负责人:Benjamin Raphael
-
依托单位:
海外基金