Positive Affect Regulation for HIV Prevention in People with Mood Disorders

描述（由申请人提供）：Judy Moskowitz博士是加州旧金山弗朗西斯科医学系和Osher中西医结合中心的副教授。作为一名社会/健康心理学家，在过去的17年里，她指导了20多名学员，并制定了一个蓬勃发展的多学科合作研究计划，重点是初级和二级艾滋病毒预防中的积极影响。莫斯科维茨博士正处于她职业生涯中获得K24资助的理想阶段。从这个奖项的支持将使她能够利用她的研究计划，以发展病人为导向的研究人员的职业生涯。她目前由NIMH资助，进行一项积极情绪调节干预的随机试验，以改善新诊断为艾滋病毒感染者的心理和身体健康。在K24的支持下，研究计划的扩展将解决两个首要问题：（1）干预对谁有效，（2）以什么形式提供？共病情绪障碍是艾滋病毒初级和二级预防的一个重要问题。该提案的研究部分概述了Moskowitz博士的研究计划的扩展，该计划将使她与一组学员一起开始解决积极影响干预的安全性，有效性，可行性和最佳交付形式等重要问题。该K24提案的总体目标是：（1）在积极情绪调节干预措施，情绪障碍，艾滋病毒等特定领域的以患者为导向的研究中，为早期职业临床医生和学员提供更广泛的指导，更广泛地说，在以患者为导向的研究中整合社会和行为科学;以及（2）扩展当前的研究计划，以定制积极影响调节干预的内容和形式，以最大限度地提高可行性，安全性，通过将修改后的干预措施转化为计算机提供的格式，提高对患有情绪障碍的人的治疗效果和有效性，并最大限度地向难以接触到的艾滋病毒风险较高的人群提供治疗。这项研究计划的最终目标是通过扩大干预措施的适用性和鼓励在家庭和社区环境中广泛传播，扩大对艾滋病毒感染者或高危人群的公共卫生影响。K24将确保有足够的时间来追求Moskowitz博士的研究的自然进展，同时保护时间来指导未来的临床研究人员进行以患者为导向的研究。发展，研究和指导计划的目的是相互补充，并在以病人为导向的研究的新方向创造指导和研究的协同效应。拟议的指导，研究和职业发展活动积极利用现有的基础设施，资源和NIH提供的培训计划，包括Moskowitz博士的积极研究计划，Osher中西医结合中心和UCSF的临床和转化科学研究所（CTSI）。

DESCRIPTION (provided by applicant): Dr. Judy Moskowitz is Associate Professor in the Department of Medicine and the Osher Center for Integrative Medicine at the University of California San Francisco. Trained as a social/health psychologist, over the past 17 years, she has mentored more than two dozen trainees and developed a thriving program of multi- disciplinary collaborative research focused on positive affect in primary and secondary HIV prevention. Dr. Moskowitz is at an ideal stage of her career for a K24 grant. Support from this award would allow her to leverage her research program to develop the careers of patient oriented researchers. She is currently funded by NIMH to conduct a randomized trial of a positive affect regulation intervention for improving psychological and physical well being in people newly diagnosed with HIV. With the support of the K24 there are two overarching questions that would be addressed by an extension of the research program: (1) for whom does the intervention work and (2) in what delivery format? Co-morbid mood disorders are a significant concern for both primary and secondary HIV prevention. The research portion of this proposal outlines an extension of Dr. Moskowitz's research program that would allow her, together with a team of mentees, to begin to address important questions of safety, efficacy, feasibility and optimal delivery format of the positive affect intervention among people with mood disorders who are at high risk for HIV. The Overall Aims of this K24 proposal are to: (1) Provide expanded mentoring of early career clinicians and trainees in patient-oriented research in the specific areas of positive affect regulation interventions, mood disorders, HIV, and, more broadly, in integration of social and behavioral sciences in patient-oriented research; and (2) Extend the current research program to tailor the content and format of a positive affect regulation intervention to maximize feasibility, safety, and efficacy for people living with mood disorders and to maximize transportability to difficult-to-reach populations who are at elevated risk of HIV by translating the modified intervention to computer-delivered format. The ultimate goal for this program of research is to amplify the public health impact for individuals living with, or at risk for, HIV, by broadening applicability of the intervention and by encouraging widespread dissemination to home and community settings. The K24 would insure sufficient time to pursue this natural progression of Dr. Moskowitz's research while protecting time to devote to mentoring future clinician investigators in patient- oriented research. The plans for development, research, and mentoring were designed to complement each other and to create a synergistic effect of mentoring and research in a new direction of patient-oriented research. The proposed mentoring, research, and career development activities actively leverage existing infrastructure, resources, and training initiatives provided by NIH, including Dr. Moskowitz's active research program, the Osher Center for Integrative Medicine, and the Clinical and Translational Science Institute (CTSI) at UCSF.