Social Consequences of Mental Disorders: A Ten-Year Follow-up Study

描述（由申请人提供）：过去的研究发现，常见的精神障碍与不良的社会结果有很强的联系，如辍学、少女怀孕、失业、婚姻不稳定和角色功能障碍。然而，在美国，大多数关于这些关联的研究都是基于横断面数据或选定人群。横断面研究无法解开精神障碍与社会逆境之间可能存在的相互关联，基于选定样本的研究也无法推广到整个人群。需要在整个人口的代表性样本中获得前瞻性数据。在美国，很少有这样的研究关注心理健康。虽然精神障碍与社会结果的关联已经在其他工业化国家的出生队列和其他纵向研究中进行了研究，但背景因素的差异，如学校系统、就业市场和失业保险政策，阻碍了结果在美国的推广。有必要在美国进行可比的研究，以记录美国精神障碍的不良后果。在这个项目中，我们建议检查5001名15-54岁的美国国家共病调查参与者中有情绪、焦虑、物质和行为障碍的终生病史的个体的不良社会和功能结果的发展，这些参与者在基线时进行了随访，并在10年后再次接受了采访。在目标1中，我们确定了基线精神障碍在多大程度上预测了随后在学业、就业、婚姻和收入方面的中断。在目标2中，我们关注先前存在的精神障碍与随后的角色功能障碍的关联。在目标3中，我们着眼于人口水平上的社会逆境，并确定这些结果中可归因于人口水平上精神障碍的比例。在Aim 4中，我们评估了精神障碍与不良结果的关联是否因性别、社会经济地位和年龄而异。分析将使用倾向评分技术来调整在精神障碍发病之前观察到的潜在混杂因素，这些混杂因素可以解释与随后结果的关联。这项研究的结果可能对正在进行的关于投资于精神障碍研究和治疗的重要性的政策辩论有用，并有助于确定有针对性干预的亚群体，以避免不良的社会后果。

DESCRIPTION (provided by applicant): Past research has found strong associations between common mental disorders and adverse social outcomes such as school drop-out, teen pregnancy, unemployment, marital instability and impairment in role functioning. However, most studies of these associations in the US have been based on cross-sectional data or selected populations. Cross-sectional studies cannot disentangle reciprocal associations likely to exist between mental disorders and social adversities and studies based on selected samples cannot be generalized to the whole population. Prospective data in representative samples of the entire population are needed. There are few such studies with a focus on mental health in the US. While the associations of mental disorders with social outcomes have been studied in birth cohort and other longitudinal studies in other industrialized countries, variations in contextual factors, such as school systems, job markets, and unemployment insurance policies hinder generalization of results to the US. There is a need for comparable US studies to document the adverse consequences of mental disorders in the US. In this project, we propose to examine the development of adverse social and functional outcomes in individuals with lifetime histories of mood, anxiety, substance and conduct disorders in the 5,001 participants of the US National Comorbidity Survey between ages 15-54 at baseline who were followed-up and re-interviewed 10 years later. In Aim 1 we determine the extent to which baseline mental disorders predict subsequent disruptions in schooling, employment and marriage as well as earnings. In Aim 2 we focus on the associations of pre-existing mental disorders with subsequent impairments in role functioning. In Aim 3 we look at social adversities at the population level and determine the proportion of these outcomes that can be attributed to mental disorders at the population level. In Aim 4, we assess whether the associations of mental disorders with adverse outcomes vary by sex, socio-economic status, and age. Analyses will use propensity score techniques to adjust for observed potential confounders preceding the onset of mental disorders that could explain associations with subsequent outcomes. Results of the study could be useful in ongoing policy debates about the importance of investing in research and treatment of mental disorders and could help identify subgroups for targeted intervention to avert adverse social outcomes.