The Metabolomics Data Center and Workbench (MDCW)

描述(由申请人提供)：该提案的目标是创建一个可伸缩和可扩展的信息学基础设施，作为国家代谢物组学资源。这是对RCMRCs的配套建议，也是代谢组学共同基金倡议的一部分。拟议的MDCW将协调国家和国际代谢组学中心和倡议的数据活动，作为国家数据储存库，并开发一个工作台，该工作台将具有数据、查询和分析界面，以及用于代谢组学数据的互动分析和整合的工具。这项拟议的工作将建立在PI实验室开发的现有脂类基础设施上，作为NIH Glue Grant脂质组学倡议的一部分。这项提议的具体目标是：a)开发代谢组学数据库、工具和界面；b)为代谢组学开发云计算基础设施；c)协调RCMRC和其他代谢组学倡议；以及d)为推进代谢组学教育和研究提供资源，以支持新的生物医学。 公共卫生相关性：这项提议的主要目标是开发一个社区驱动的代谢组学数据存储库。更具体地说，拟议的中心将协调RCMRCs的信息学工作，并将来自核心和其他代谢组学工作的所有数据提交给生物医学研究社区。此外，该提案将建立一个适用于代谢组学研究的计算基础设施。最重要的是，该中心将为涉及代谢组学的下一代生物医学研究提供使能的信息学基础设施。

DESCRIPTION (provided by applicant): The objective of this proposal, Metabolomics Data Center and Workbench (MDCW), is the creation of a scalable and extensible informatics infrastructure which will serve as a national metabolomics resource. This is a companion proposal to RCMRCs and is a part of the Common Fund Initiative in metabolomics. The proposed MDCW will coordinate data activities of national and international metabolomics centers and initiatives, serve as a national data repository and develop a Workbench that will have data, query and analysis interfaces, and tools for interactive analysis and integration of metabolomics data. The proposed work will build on the extant infrastructure for lipids developed by the PI's laboratory as a part of the NIH Glue Grant initiative on Lipidomics. The specific objectives of this proposal are, a) development of a metabolomics data repository, tools and interfaces, b) develop a cloud computing infrastructure for metabolomics, c) coordinate RCMRCs and other metabolomics initiatives and d) provide the resources for advancing metabolomics education and research to enable new biomedicine. PUBLIC HEALTH RELEVANCE: The major aim of this proposal is the development of a community-driven data repository for metabolomics. More specifically, the proposed Center will coordinate informatics efforts of RCMRCs and present all data from the Cores and other metabolomics efforts to the biomedical research community. In addition, the proposal will build a computational infrastructure that will be appropriate for metabolomics research. Most importantly, the Center will provide the enabling informatics infrastructure for next generation biomedical research involving metabolomics.