Inhibition of necroptosis as a novel strategy for the prevention of bronchiolitis and subsequent asthma

抑制坏死性凋亡作为预防细支气管炎和随后的哮喘的新策略

• 批准号: nhmrc : 1141581
• 负责人: A/Pr Simon Phipps
• 金额: $ 44.49万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/inhibition-necroptosis-novel-subsequent-asthma/1319512
• 关键词: Inhibition; necroptosis; novel; strategy; prevention

Severe virus associated bronchiolitis is a major cause of infant mortality and a risk factor for asthma. Using a mouse model, we have shown that virus infection causes tissue damage, leading to the release of 'danger' molecules that promote excessive inflammation and tissue remodelling. We have identified an important mechanism by which the danger molecules are released. We will now assess whether blocking this process ameliorates viral bronchiolitis and breaks its nexus with subsequent asthma.

严重的病毒相关性细支气管炎是婴儿死亡的主要原因，也是哮喘的危险因素。使用小鼠模型，我们已经证明病毒感染会导致组织损伤，导致释放“危险”分子，促进过度炎症和组织重塑。我们已经确定了释放危险分子的一个重要机制。我们现在将评估阻断这一过程是否能改善病毒性细支气管炎并打破其与随后哮喘的联系。