Defective toll-like receptor 7 signalling in plasmacytoid dendritic cells underlies the inception of virus-associated asthma

浆细胞样树突状细胞中 Toll 样受体 7 信号传导缺陷是病毒相关哮喘发生的基础

• 批准号: nhmrc : 1023756
• 负责人: A/Pr Simon Phipps
• 金额: $ 36.83万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/defective-toll-like-associated-asthma/110300
• 关键词: Defective; toll; like; receptor; signalling

In genetically susceptible individuals, respiratory virus infections are a risk factor for asthma inception and are the most common cause of acute exacerbations. Using a clinically relevant mouse model of disease, this study will investigate whether the altered expression of toll-like receptor 7, a host protein that senses viral invasion, causes the host to mount an inappropriate pro-allergic immune response to the virus.

在遗传易感个体中，呼吸道病毒感染是哮喘发病的危险因素，也是急性加重的最常见原因。使用临床相关的疾病小鼠模型，本研究将研究toll样受体7（一种感知病毒入侵的宿主蛋白）的表达改变是否会导致宿主对病毒产生不适当的促过敏免疫反应。