Pneumovirus infection in infancy affects the development of life-long adaptive immunity.

婴儿期肺炎病毒感染会影响终生适应性免疫的发展。

• 批准号: nhmrc : 510718
• 负责人: A/Pr Simon Phipps
• 金额: $ 27.24万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/pneumovirus-infection-infancy-adaptive-immunity/96188
• 关键词: Pneumovirus; infection; infancy; affects; development

Respiratory syncytial virus is the most important cause of acute lower respiratory tract infection (RTI) in young children worldwide. Hospital admission rates in Western societies for RTIs are around 3% for children younger than 1 year. A vaccine to RSV is not yet available and repeat infections occur thoughout life, suggesting that the immune response does not develop correctly. In this project we are exploring the mechanisms that underpin disease development and promote incomplete immunity.

呼吸道合胞病毒是全世界幼儿急性下呼吸道感染（RTI）的最重要原因。在西方社会，1岁以下儿童的rti住院率约为3%。目前还没有针对呼吸道合胞病毒的疫苗，而且在人的一生中会发生重复感染，这表明免疫反应没有正确发展。在这个项目中，我们正在探索支持疾病发展和促进不完全免疫的机制。