Coping With HIV/AIDS in Tanzania

坦桑尼亚应对艾滋病毒/艾滋病

• 批准号: 8534365
• 负责人: KATHRYN WHETTEN
• 金额: $ 13.55万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-06 至 2014-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8534365
• 关键词: AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Address; Adherence; Adult; Adverse effects; Africa South of the Sahara; Aftercare; Age; Antiretroviral drug resistance; Anxiety; Appointment; Area; Bed Occupancy; Belief; CD4 Lymphocyte Count; Caregivers; Caring; Case Manager; Characteristics; Child Care; Clinic; Clinical Data; Cohort Studies; Communicable Diseases; Counseling; Country; Cross-Sectional Studies; Data; Data Analyses; Data Collection; Deltastab; Diagnosis; Disease; Disease Progression; Economic Factors; Economics; Education; Emergency Situation; Enrollment; Ensure; Ethnic Origin; Event; Funding; Future; Gender; HIV; HIV Infections; HIV Seropositivity; HIV diagnosis; Health; Health Promotion; Health Status; Health behavior; Healthcare; Home environment; Housing; Human immunodeficiency virus test; Income; Individual; International; International AIDS; Intervention; Interview; Knowledge; Laboratories; Lead; Life; Life Experience; Link; Location; Malaria; Mediator of activation protein; Medical; Medical center; Mental Depression; Mental Health; Modeling; Morbidity - disease rate; Newly Diagnosed; Orphan; Outcome; Participant; Patients; Peer Review; Persons; Pharmaceutical Preparations; Physicians; Play; Policies; Population Study; Predisposition; Prevention; Prevention education; Protocols documentation; Provider; Psychosocial Factor; Public Health; Quality of life; Recruitment Activity; Regimen; Reporting; Research; Research Personnel; Resistance; Resources; Respondent; Risk; Risk Behaviors; Risk Reduction; Role; Rural; Sampling; Self Efficacy; Series; Services; Severities; Sexual abuse; Site; Social support; Socioeconomic Status; Stigmata; Stress; Symptoms; System; Tanzania; Testing; Time; Time Study; Transportation; Trauma; Treatment Efficacy; Treatment Protocols; Treatment outcome; Trust; Tuberculosis; Universities; Viral Load result; Virus; Woman; Work; antiretroviral therapy; base; care seeking; cohort; coping; cost; cost effective; demographics; design; diaries; ethnic minority population; fighting; health care service utilization; health related quality of life; high risk; high risk sexual behavior; improved; interest; medication compliance; mortality; patient population; physical abuse; pill; programs; psychological distress; psychosocial; research study; residence; scale up; service utilization; social stigma; symposium; tertiary care; treatment adherence; urban area; viral resistance

Two-thirds of the >38 million people with HIV/AIDS reside in Sub-Saharan Africa. Access to antiretroviral therapy (ART) in less wealthy nations is expanding quickly, creating an urgent need to understand those factors influencing adherence, a key determinant of ongoing efficacy of ART, so that the creation and spread of medication-resistant virus is limited. The proposed research team has identified suboptimal adherence among 29% of clinic attendees taking ART for > 6 months in Moshi Tanzania, while documenting lack of virologic suppression in 32% and antiretroviral drug resistance in 10%. We propose to follow 750 newly diagnosed HIV+ persons, 500 previously diagnosed HIV+ persons and 750 HIV-negative persons in over 3 years in this region. The newly diagnosed HIV+ and HIV- cohorts will be obtained through consecutive sampling in a Voluntary Counseling and Testing (VCT) site and the on-going HIV+ cohort will be similarly drawn from the Infectious Disease Clinic (IDC) in the tertiary care medical center 5 miles away. This research team has a track record of successful past and ongoing research at both the VCT and the IDC sites. Baseline data we will used to examine associations between psychosocial (including trauma, mental health symtomotology, coping strategies and life events), sociodemographic, and economic factors and health status, adherence to ART, and health promotion and high risk activities. Longitudinal analyses will examine causal relationships between changes in the independent and dependent variables. Results will lead to the creation of more effective prevention and care models for the area and other similar areas. Studying the population of ART naive patients in a resource poor setting provides a unique window of opportunity to gather data designed to increase our understanding of underlying variables associated with maladherence and risk behaviors. Psychosocial determinants are a unique strength of this proposal. The study will result in a minimum of 7 peer reviewed articles and disemination of findings at annual national (US and Tanzanian) and international AIDS, Public Health and Mental Health conferences, including the annual Tanzania national AIDS conference. A policy related report will be diseminated to national and international leaders.

3800万艾滋病毒/艾滋病患者中有三分之二居住在撒哈拉以南非洲。访问