Inhibition of interferon-alpah-beta by chikungunya virus and the induction of arthritis

基孔肯雅病毒对干扰素-α-β的抑制和关节炎的诱导

• 批准号: nhmrc : 613622
• 负责人: Dr Yutaro Kumagai
• 金额: $ 47.29万
• 依托单位: Queensland Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/inhibition-interferon-alpah-induction-arthritis/82350
• 关键词: Inhibition; interferon; alpah; beta; chikungunya

Chikungunya virus is a mosquito borne virus which has caused epidemics of arthritis around the world (recently 260,000 people Reunion Island, France and 1.6 million people in India). The virus is ordinarily very sensitive to the main mammalian anti-viral defence system (interferon alpha-beta). This grant seeks to understand how, despite the activation of this system during infection, the virus manages to persist and cause 3-6 months of debilitating arthritis.

基孔肯雅病毒是一种由蚊子传播的病毒，已在世界各地引起关节炎流行（最近法国留尼汪岛有 26 万人，印度有 160 万人）。该病毒通常对主要的哺乳动物抗病毒防御系统（干扰素α-β）非常敏感。这笔赠款旨在了解尽管该系统在感染过程中被激活，但病毒如何能够持续存在并导致 3-6 个月的衰弱性关节炎。